A5068757123- Fatty Acid Research and Health
- Heavy Metal Exposure and Toxicity
- Graphene and Nanomaterials Applications
- Phytoestrogen effects and research
- Mercury impact and mitigation studies
- Advanced Glycation End Products research
Chengdu Medical College
2023
Mercury is a toxic, environmentally heavy metal that can cause severe damage to all organs, including the nervous system. The functions of puerarin include antioxidant, anti-inflammatory, nerve cell repair, regulation autophagy, and so forth. But because limited oral absorption puerarin, it affects protective effect on brain tissue. nano-encapsulation Pue improve its limitation. Therefore, this study investigated drug-loaded PLGA nanoparticles (Pue-PLGA-nps) injury induced by mercuric...
To observe the metabolic changes and antialcoholic effect of Puerarin-PLGA nanoparticles (PUE-NP) in mice. PUE-NP was prepared characterized by particle size distribution morphology. The mouse models with acute alcoholism were established to their behavioral after alcohol poisoning. expressions biologically active enzymes such as CRE, BUN, AST, ALT serum SOD TLR4 liver mice each group detected, pathological kidney tissues observed HE staining. metabolism determined vitro release assay HPLC....