A5018817468- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Diabetes and associated disorders
- Genomics, phytochemicals, and oxidative stress
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2022-2025
Universitat Autònoma de Barcelona
2023-2025
Hospital Universitari Germans Trias i Pujol
2022
Abstract Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time CD4 + subsets AC-patients. included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During follow-up, TEMRA T cells increased (1.2 ± 1.1% vs. 2.1 1.1%, p = 0.03) AC-patients ( n 5) Th17 decreased (14.1...
Two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms contribution laboratory variables is limited.To measure performance currently used tests alone or combined with explore power immunological adequate laboratories. Methods: Data from 2,600 patients first wave Barcelona area (exploratory cohort 1,579, validation cohorts 598 423 patients) including parameters were retrospectively collected. 28-day...
ABSTRACT Background The antibody response to SARS-CoV-2 does not follow the immunoglobulin isotype pattern expected in a primary and is inconsistent with current interpretation of COVID-19 immunopathology as result infection. To better understand immune SARS-CoV-2, it essential determine whether or secondary (or recall). analysis highly granular immunological variable trajectories homogeneous cohort patients receiving standardised medical care should discern between responses. Methods This...
T cells, natural killer (NK) and NKT cells have opposing actions in the development of alcohol-associated liver fibrosis. We aimed to evaluate phenotype NK activated patients with alcohol use disorder (AUD) according presence advanced fibrosis (ALF). Totally, 79 (51-years, 71% males) were admitted treatment AUD. ALF was defined as FIB4-score > 2.67. Immunophenotyping (CD3-CD56+CD16+, CD3-CD56+CD16-, CD3-CD56-CD16+), NKT-like (CD3+CD56+), activation status CD4+, CD8+ regulatory (Tregs)...
Abstract Background Almost two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted, nor new tests identified to improve prediction and management SARS-CoV-2 infection. Methods Retrospective observational analysis performance clinical parameters laboratory in hospitalised patients with COVID-19. Outcomes were 28-day survival maximal severity a cohort 1,579 validation cohorts 598 434 patients. A pilot study conducted patient subgroup measured 17...