A5074349109- RNA Research and Splicing
- Animal Genetics and Reproduction
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA regulation and disease
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Caveolin-1 and cellular processes
- Esophageal and GI Pathology
- Foreign Body Medical Cases
- Helicobacter pylori-related gastroenterology studies
Fudan University
2023
Dezhou University
2019-2021
Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease. Cholesterol availability critical ISC stemness. Low plasma cholesterol typical feature of Crohn's disease (CD); however, its impact on mucosal healing remains unclear. Here, we identified an essential role sorting nexin 10 (SNX10) in maintaining the stemness ISCs. SNX10 expression intestinal tissues positively correlates with severity human CD and mouse colitis. Conditional knockout epithelial cells...
Abstract Background It is believed that natural selection acts on the phenotypical changes caused by mutations. Phenotypically, from fishes to amphibians reptiles, emergence of limbs greatly facilitates landing ancient vertebrates, but causal mutations and evolutionary trajectory this process remain unclear. Results We serendipitously obtained a pig limbless phenotype. Mutations specific handicapped were identified using genome re-sequencing comparative genomic analysis. narrowed down...
Objective: To explore the clinical characteristics and treatment methods of esophageal foreign body. Method: The data 234 patients with bodies admitted to our department from January 2015 August 2018 were retrospectively analyzed, including course time, body types, surgical methods, imaging manifestations related complications. Result: diagnosis was confirmed by CT or barium meal X-ray examination before operation in patients. Course time varied 3 hours 7 days, jujube nucleus most common...