A5038898019- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- biodegradable polymer synthesis and properties
- Medical Imaging and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Polymer Nanocomposites and Properties
- Hydrogels: synthesis, properties, applications
- Crystallization and Solubility Studies
- Polymer crystallization and properties
- 3D Printing in Biomedical Research
- X-ray Diffraction in Crystallography
- Bone Tissue Engineering Materials
- Nanocomposite Films for Food Packaging
- Forensic Fingerprint Detection Methods
- Crystal structures of chemical compounds
- Electrospun Nanofibers in Biomedical Applications
- Surfactants and Colloidal Systems
- Organometallic Compounds Synthesis and Characterization
- Advanced Drug Delivery Systems
- Cancer Cells and Metastasis
- Corrosion Behavior and Inhibition
- Shoulder Injury and Treatment
- Crystallography and molecular interactions
- Supramolecular Self-Assembly in Materials
Sheffield Hallam University
2015-2024
AO Foundation
2019
University of Pennsylvania
2019
Tokai University
2019
Martin University
2019
AO Foundation
2019
University of Delaware
2019
University of Manchester
2007
Instituto de Agroquímica y Tecnología de Alimentos
2006
Bristol-Myers Squibb (United Kingdom)
2005
Poly lactide-co-glycolide (PLGA) is an important polymer matrix used to provide sustained release across a range of active pharmaceutical ingredients (APIs) and works by hydrolytic degradation within the body, thereby releasing entrapped drug. Processing sterilisation can impact on morphology chemistry PLGA therefore influencing hydrolysis rate in turn any API. This paper has looked at effect supercritical carbon dioxide (scCO2) processing, gamma irradiation, comonomer ratio temperature...
This study investigated the efficiency of mixing bentonite with chitosan via different preparation methods, subsequently forms were for their ability to remove Pb(II) ions from solution. The bentonite-chitosan (Bt-Ch), composites and beads, prepared solution blending precipitation respectively in weight ratios 90%/10%, 70%/30% 50%/50%. beads further subdivided, identified as "beads-A" "beads-B", formed by adding either suspension or powder, respectively, solubilised characterised X-ray...
We report a systematic FTIR study of the perturbation water "sorbed" into polymers PET and PVC as function crystallinity (PET) or plasticizer content (PVC). Band shapes composite ν(OH) band H2O obtained by ATR technique have been fitted to individual components,corresponding those recently found for pure itself. A detailed quantitative analysis frequency shifts relative intensties has led conclusion that these component bands show direct evidence breaking network in polymer matrix this...
In the present study, circular economy based and potentially low-cost poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was produced by mixed microbial cultures derived from fruit pulp, an industrial by-product of juice industry. Three different chemical routes, namely non extraction, extraction with sodium hypochlorite (NaClO), chloroform, in combination filtering centrifugation, were explored to purify biopolymer find most optimal solution for its processing via electrospinning. The...
Sexual offenders are increasingly reported to use condoms while committing the crime, mainly prevent transfer of DNA evidence. Although often removed from crime scene, vaginal swabs can be taken victim prove presence condom lubricants and therefore evidence corpus delicti. However, late reporting police tendency wash immediately after may compromise detection lubricants. Recently we showed that Matrix-Assisted Laser Desorption/Ionisation MS Imaging (MALDI MSI) contaminated fingermarks...
// Abbey A. Thorpe 1 , Abbie L.A. Binch Laura B. Creemers 2 Christopher Sammon 3 and Christine L. Le Maitre Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK UMC Utrecht, Orthopaedics Department, Netherlands Materials Engineering Institute, Correspondence to: Maitre, email: Keywords : nucleus pulposus, phenotypic markers, regeneration, stem cells PAX1, FOXF1, Pathology Section Received October 15, 2015 Accepted December 22, Published 28, Abstract Progress in...
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) without additional growth factors. The clinical success this is dependent on: integration with surrounding tissue; the capacity restore mechanical function; as well supporting viability and delivered MSCs. Bovine NP tissue explants were injected media (control), human MSCs (hMSCs) alone, acellular...
Abstract The in vitro study of the pathogenesis inflammatory bowel disease (IBD) requires a cell model which closely reflects characteristics vivo intestinal epithelium. This aimed to investigate application L-pNIPAM hydrogel as scaffold develop long-term 3D co-culture Caco-2 and HT29-MTX cells under conditions analogous inflammation, determine its potential use studying IBD. Monocultures co-cultures were layered on scaffolds maintained dynamic culture for up 12 weeks. Treatments with IL-1β,...
// Rasha H. Dosh 1 , 3 Nicola Jordan-Mahy Christopher Sammon 2 and Christine Le Maitre Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK Materials Engineering Institute, Department of Anatomy Histology, Faculty Medicine, University Kufa, Iraq Correspondence to: Maitre, email: c.lemaitre@shu.ac.uk Keywords: IL-1Ra deficient; inflammatory bowel disease; pro-inflammatory cytokines; matrix-degrading enzymes; intestinal enzymes Received: October 23,...
This study originally explores the use of gallic acid (GA) as a natural additive in bio-based high-density polyethylene (bio-HDPE) formulations. Thus, bio-HDPE was first melt-compounded with two different loadings GA, namely 0.3 and 0.8 parts per hundred resin (phr) biopolymer, by twin-screw extrusion thereafter shaped into films using cast-roll machine. The resultant containing GA were characterized terms their mechanical, morphological, thermal performance well ultraviolet (UV) light...
ABSTRACT Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disability and leads to enormous healthcare toll worldwide. Biological treatment with growth factors has evolved as potential therapy for IVD regeneration. Bone morphogenetic protein 2 (BMP‐2) BMP‐7 have shown promise in this regard. In current study, we evaluated effect BMP‐2/7 heterodimer regeneration both vitro organ culture. Nucleus pulposus (NP) cells isolated from bovine caudal were...
A bottom up in situ proteomic method has been developed enabling the mapping of multiple blood signatures on intact ridges fingermarks by Matrix Assisted Laser Desorption Mass Spectrometry Imaging (MALDI‐MSI). This method, at a proof concept stage, builds upon recently published work demonstrating opportunity to profile and identify bloodstains via approach. The present protocol addresses limitation previously profiling with respect destructivity; destructivity should be avoided for evidence...
Bone loss associated with degenerative disease and trauma is a clinical problem increasing the aging population. Thus, effective bone augmentation strategies are required; however, many have disadvantages that they require invasive surgery often addition of expensive growth factors to induce osteoblast differentiation. Here, we investigated LaponiteÒ crosslinked, pNIPAM-DMAc copolymer (L-pNIPAM-co-DMAc) hydrogel hydroxyapatite nanoparticles (HAPna), which can be maintained as liquid ex vivo,...