A5101720193- HIV/AIDS Research and Interventions
- Gut microbiota and health
- HIV Research and Treatment
- HIV-related health complications and treatments
- Reproductive tract infections research
- Listeria monocytogenes in Food Safety
- Cancer Immunotherapy and Biomarkers
- Urinary Tract Infections Management
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Sleep and related disorders
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Sleep and Wakefulness Research
- Orthopedic Infections and Treatments
- Pelvic floor disorders treatments
- Escherichia coli research studies
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Sarcoidosis and Beryllium Toxicity Research
- Antibiotic Resistance in Bacteria
- Child Nutrition and Feeding Issues
Rush University Medical Center
2014-2024
Tango Therapeutics (United States)
2024
Ruth M. Rothstein CORE Center
2015-2019
Rush University
2019
Johns Hopkins University Center for AIDS Research
2015
Cook County Health and Hospitals System
2015
Mater Adult Hospital
1996
BackgroundUrinary tract infections (UTI) affect approximately 250 million people annually worldwide. Patients often experience a cycle of antimicrobial treatment and recurrent UTI (rUTI) that is thought to be facilitated by gut reservoir uropathogenic Escherichia coli (UPEC).Methods125 patients with caused an antibiotic-resistant organism (ARO) were enrolled from July 2016 May 2019 in longitudinal, multi-center cohort study. Multivariate statistical models used assess the relationship...
Abstract Background Dipeptidyl peptidase-4 (DPP-4) inhibitors have pleotropic anti-inflammatory and immune regulatory effects in addition to glucoregulation. We evaluated inflammation markers suppressed human immunodeficiency virus (HIV) infection during treatment with the DPP-4 inhibitor sitagliptin. Methods Virologically adults HIV without diabetes on stable antiretroviral therapy (ART) ≥100/μL CD4 cells were randomized 16 weeks of sitagliptin 100 mg/day vs placebo a multicenter trial. The...
To describe a case of systemic desquamating dermatitis following implantation vancomycin antibiotic-laden cement (ABLC) in patient with prior history Stevens-Johnson (SJS) reaction to vancomycin.A 59-year-old man SJS and recurrent methicillin-susceptible Staphylococcus aureus prosthetic knee infection developed painful, blistering rash after bone that had been mixed 2 g vancomycin. He was started empirically on steroids by his primary care provider desquamation about 1 week later.Systemic...
Abstract Background A5350, a phase II, randomized, double-blind study, evaluated the safety and tolerability of probiotic Visbiome Extra Strength (ES) over 24 weeks measured effects on inflammation intestinal barrier function. Methods The primary outcome was change in soluble CD14 (sCD14) levels; secondary outcomes included tolerability, markers cellular activation, microbiome. In substudy, gut permeability assessed by paired colonic biopsies measuring area lamina propria occupied CD4+...
The relationship between markers of monocyte/macrophage activation (sCD14 and sCD163) components the Veterans Aging Cohort Study (VACS) score, which predict mortality in patients with HIV, immunologic nonresponders (INRs) is not defined. HIV(+) subjects >12 months continuous virologic suppression persistent CD4 <250 cells/mm(3) were enrolled at CORE Center, Chicago. Subjects had a single visit where history was taken blood drawn. ELISA assays for sCD14 sC163 performed Blood Systems, CA....
The role of microbiota in the pathogenesis HIV infection has become subject intense research recent years. A rapidly growing amount data suggest that microbial dysbiosis-in gut or genital tract-can influence transmission and/or disease progression; however, a deeper understanding mechanisms involved is lacking. To better understand relationship between microbiome and infection, investigators from wide variety disciplines, including those working basic clinical studies, cardiovascular...
Introduction: HIV-infected individuals have evidence of intestinal microbial translocation which is associated with immune activation and unfavorable clinical outcomes. Rifaximin, a non-absorbable antibiotic reduces in other disease states, was shown to marginal beneficial effect on translocation, T-cell activation, inflammation multisite randomized trial (ACTG A5286; NCT01466595) persons poor immunologic recovery receiving ART. Here, we report analysis the rectal microbiome changes that...
It remains unclear whether differences in gut microbiota noted between HIV-infected and uninfected individuals are driven by HIV or sexual behavior. We evaluated rectal swab of women with similar demographic, neighborhood, diet characteristics enrolled the Chicago Women's Interagency Study (WIHS). DNA was amplified for sequencing fragments bacterial small subunit (SSU 16S) ribosomal RNA (rRNA) genes. did not differ Shannon diversity index (p = .14), non-metric multidimensional scaling (NMDS)...
Each year, a growing international collection of researchers meets at the NIH to share and discuss developments in microbiome HIV story. This past year has seen continued progress toward detailed understanding host–microbe interactions both within outside field HIV. Commensal microbes are being linked an ever-growing list maladies physiologic states, including major depressive disorder, chronic kidney disease, Parkinson disease. PubMed citations for "microbiome" exponential rate with over...
As immune checkpoint inhibitor (ICI) therapy becomes increasingly popular for the treatment of cancer, there is a growing body literature on opportunistic infections associated with ICI therapy. Pembrolizumab binds specifically to PD-1 receptor T cells, preventing PD-1’s interaction PD-L1 and PD-L2. This blockade interrupts inhibitory signal restores cell’s ability recognize attack tumor cells. We present case invasive Listeria infection The also suggests treating patients undergoing active...
As immune checkpoint inhibitor (ICI) therapy becomes increasingly popular for the treatment of cancer, there is a growing body literature on opportunistic infections associated with ICI therapy. Pembrolizumab binds specifically to PD-1 receptor T cells, preventing PD-1’s interaction PD-L1 and PD-L2. This blockade interrupts inhibitory signal restores cell’s ability recognize attack tumor cells. We present case invasive Listeria infection The also suggests treating patients undergoing active...
Abstract CRISPR-based functional genomics screening can be designed to identify novel cancer cell intrinsic targets that increase tumor immunogenicity. Using a FACS-based CRISPR sorting screen for PD-L1 expression, we identified Euchromatic histone-lysine-N-methyltransferase 1 and 2 (EHMT1/2) as negative modulators of the interferon signaling pathways. EHMT1 EHMT2 are histone methyltransferases mono- di-methylate lysine 9 H3 repress gene transcription defined target genes. Gene knockout or...
Commensal organisms appear to play significant roles in normal homeostasis as well the pathogenesis of HIV infection a number different organ systems. On November 17th and 18th, 2016, leading researchers from around world met discuss their insights on advances our understanding microbiome at National Institutes Health (NIH) Bethesda. Dr. Elhanan Borenstein University Washington gave keynote address where he discussed new developments systems biology which hold promise illuminating pathways...
Our microbial cotravelers have increasingly apparent roles in both maintaining health and causing disease several organ systems. Investigators gather annually at the National Institutes of Health to present new discoveries regarding role microbiome human a special focus on persons living with HIV. Here, we summarize discussions from third annual Virology Education workshop HIV, which took place October 2017.