A5059830387- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Axon Guidance and Neuronal Signaling
- MicroRNA in disease regulation
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Photoreceptor and optogenetics research
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Neural dynamics and brain function
- Kruppel-like factors research
- Congenital gastrointestinal and neural anomalies
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Autism Spectrum Disorder Research
- Biomedical and Engineering Education
- Hereditary Neurological Disorders
- Advanced Fluorescence Microscopy Techniques
- Olfactory and Sensory Function Studies
- Retinal Development and Disorders
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Congenital Heart Disease Studies
- Spaceflight effects on biology
University of Puerto Rico System
2021
University of Puerto Rico, Medical Sciences Campus
2018-2020
Universidad Nacional Autónoma de México
2008-2018
University of California, Los Angeles
2012-2014
UCLA Health
2014
Max Planck Institute of Experimental Medicine
2007-2011
Charité - Universitätsmedizin Berlin
2011
Autonomous University of Queretaro
2010
Max Planck Society
2007-2009
Neural stem cells (NSCs) generate new granule throughout life in the mammalian hippocampus. Canonical Wnt signaling regulates differentiation of NSCs towards neuronal lineage. Here we identified prospero-related homeodomain transcription factor Prox1 as a target β-catenin–TCF/LEF vitro and vivo. overexpression enhanced whereas shRNA-mediated knockdown impaired generation neurons within hippocampal niche. In contrast, was not required for survival adult-generated after they had matured,...
Smad-interacting protein-1 (Sip1) [Zinc finger homeobox (Zfhx1b)] is a transcription factor implicated in the genesis of Mowat–Wilson syndrome humans. Sip1 expression dorsal telencephalon mouse embryos was documented from E12.5. We inactivated gene specifically cortical precursors. This resulted lack entire hippocampal formation. mutant mice exhibited death differentiating cells and decreased proliferation region prospective hippocampus dentate gyrus. The Wnt antagonist Sfrp1 ectopically...
Cajal–Retzius (C-R) cells play important roles in the lamination of mammalian cortex via reelin secretion. The genetic mechanisms underlying development these neurons have just begun to be unraveled. Here, we show that two closely related LIM-homeobox genes Lhx1 and Lhx5 are expressed + various regions mouse telencephalon at or adjacent sites where C-R generated, including cortical hem, mantle region septal/retrobulbar area, ventral pallium. Whereas is all reelin-expressing domains,...
Pyramidal neurons in layers 2/3 and 5 of primary somatosensory cortex (S1) exhibit somewhat modest synaptic plasticity after whisker input deprivation. Whether involved at earlier steps sensory processing show more or less has not yet been examined. Here, we used longitudinal vivo two-photon microscopy to investigate dendritic spine dynamics apical tufts GFP-expressing layer 4 (L4) pyramidal the vibrissal (barrel) S1 unilateral trimming. First, characterize molecular, anatomical,...
Abstract During early vertebrate forebrain development, pioneer axons establish a symmetrical scaffold descending longitudinally through the rostral forebrain, thus forming tract of postoptic commissure (TPOC). In mouse embryos, this begins to appear at embryonic day 9.5 (E9.5) as bundle tightly constrained specific dorsoventral level. We have characterized participation Slit chemorepellants and their Robo receptors in control TPOC axon projection. E9.5–E11.5 Robo1 Robo2 are expressed...
The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, tegmental regions. Here we demonstrate Lhx5, LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, required for generation MM its derived tracts. markers Foxb1, Sim2 Lhx1 are absent Lhx5 knock-out mice from embryonic stages, suggesting abnormal specification this region. This was supported by absence Nkx2.1...
Acquisition of specific neuronal identity by individual brain nuclei is a key step in development. However, how the mechanisms that confer are integrated with upstream regional specification networks still mysterious. Expression Sonic hedgehog (Shh), required for hypothalamic and later downregulated Tbx3 to allow differentiation tubero-mamillary region. In this region, mamillary body (MBO), large aggregate essential memory formation. To clarify MBO acquired after specification, we...
Early telencephalic development involves the migration of diverse cells types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) emanate mainly from cortical hem and to a lesser extent rostrolateral, septal caudo-medial regions. One additional territory proposed give rise CR migrate dorsally into neocortex lies at ventral pallium, although contradictory results question this notion. With use cell-permeable fluorescent tracer in cultured...
SUMMARY The laminar architecture of the mammalian neocortex depends on orderly generation distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. We identify critical roles for Foxp1 in maintaining RG identity and gating temporal competency early neurogenesis. High levels are associated with aRG required to promote proliferation influence cell division symmetry, favoring expansion production born neurons. potent pro-progenitor functions revealed through its ability...
Stereotypic cell migrations in the developing brain are fundamental for proper patterning of regions and formation neural networks. In this work, we uncovered rat, a population neurons expressing tyrosine hydroxylase that migrates posteriorly from alar plate midbrain, neurophilic interaction with axons mesencephalic nucleus trigeminal nerve. A fraction was also shown to traverse mid-hindbrain boundary, reaching vicinity locus coeruleus rhombomere 1. This migratory population, however, does...
Event Abstract Back to Steady-state dynamics and experience-dependent plasticity of dendritic spines layer 4/5a pyramidal neurons in somatosensory cortex Amaya Miquelajauregui1, Sahana Kribakaran1, Ricardo Mostany2, Aurora Badaloni3, Giacomo Consalez3 Carlos Portera-Cailliau1* 1 UCLA, Dept. Neurology , United States 2 Tulane University School Medicine, Pharmacology, 3 San Raffaele Scientific Institute, Div. Neuroscience, Italy The steady state (L) 2/3 L5B cortical have recently been assessed...