A5037080010- Tea Polyphenols and Effects
- Nutrition, Genetics, and Disease
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Analysis
- Retinoids in leukemia and cellular processes
- Carcinogens and Genotoxicity Assessment
- Ecology and Conservation Studies
- Medicinal Plant Research
- Epigenetics and DNA Methylation
- Aquaculture Nutrition and Growth
- Medical research and treatments
- Tannin, Tannase and Anticancer Activities
- Insect Utilization and Effects
- Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Physiological and biochemical adaptations
- Chemical Reactions and Isotopes
- Genomics, phytochemicals, and oxidative stress
- Botany and Geology in Latin America and Caribbean
- Antioxidant Activity and Oxidative Stress
- Plant-derived Lignans Synthesis and Bioactivity
- Microbial Metabolites in Food Biotechnology
- Aquaculture disease management and microbiota
- Natural Compounds in Disease Treatment
University of Minho
2010-2015
Universidade do Porto
2008
Salvia officinalis and some of its isolated compounds have been found to be preventive DNA damage increased proliferation in vitro colon cells. In the present study, we used azoxymethane model test effects S. on cancer prevention vivo. The results showed that sage treatment reduced number ACF formed only if administered before injection, demonstrating tea drinking has a chemopreventive effect colorectal cancer. A decrease marker Ki67 H2O2-induced azoxymethane-induced colonocytes lymphocytes...
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading possible mutations if replication proceeds without proper repair. However, some are used in cancer therapy due their ability induce subsequently apoptosis of tumor cells. In this study, the genotoxic effects hydrogen peroxide (H2O2) N-methyl-N-nitrosourea (MNU) 1,3-bis-(2-chloroethyl)-1-nitosourea (BCNU) were examined two colon cell lines (HCT15 CO115). was assessed comet assay with lesion-specific...
Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation genetic epigenetic alterations, transforming normal colon cells giving them growth advantage. Epigenetic alterations are reversible studies have shown that dietary compounds can alter the status reactivate epigenetically-silenced genes. Many food plants rich bioactive to posses anticancer properties. We proposed explore effects sage (Salvia...
Diet is an important factor in colorectal cancer. Although some dietary habits have been associated with cancer promotion, for example high-fat diets, diets rich fruits and vegetables shown preventive potential. A recent study from our lab showed vitro chemopreventive effects of natural compounds by protection against oxidative DNA damage stimulation repair. It demonstrated that ursolic acid (UA), a compound found apples prunes, protects also increases repair activity Caco-2 cells these...
KRAS mutations are frequent in colorectal cancer (CRC) and have the potential to activate proliferation inhibit cell death through effects on MAPK/ERK PI3K/Akt signaling pathways. Because diet is one of most important determinants CRC incidence progression, we studied dietary triterpenoid ursolic acid (UA) induction human derived mutated lines. Our results show that UA decreases induces while decreasing as indicated by a decrease ERK Akt phosphorylation (western blot). also induced...