A5003930071- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Blood disorders and treatments
- Microscopic Colitis
- Hematological disorders and diagnostics
- Pneumothorax, Barotrauma, Emphysema
- Cerebrospinal fluid and hydrocephalus
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Drug-Induced Hepatotoxicity and Protection
- Case Reports on Hematomas
- Gastric Cancer Management and Outcomes
- Lower Extremity Biomechanics and Pathologies
- COVID-19 diagnosis using AI
- Fetal and Pediatric Neurological Disorders
- Vascular Procedures and Complications
- Neonatal Health and Biochemistry
- Central Venous Catheters and Hemodialysis
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Orthopedic Infections and Treatments
- Pharmacogenetics and Drug Metabolism
Nuffield Orthopaedic Centre
2023-2025
Wexham Park Hospital
2020-2024
Frimley Health NHS Foundation Trust
2020-2024
John Radcliffe Hospital
2023
University of Oxford
2023
Stoke Mandeville Hospital
2021-2023
Buckinghamshire Healthcare NHS Trust
2022
Frimley Park Hospital
2020
University of Cyprus
2020
Royal Berkshire NHS Foundation Trust
2019
ABSTRACT Purpose Older adults are more likely to be vitamin D deficient. The aim of the study was determine whether these patients have worse outcomes with COVID-19. Methods We conducted a prospective cohort between 1 March and 30 April 2020 assess importance deficiency in older consisted aged ≥65 years presenting symptoms consistent COVID-19 (n=105). All were tested for serum 25-hydroxyvitamin (25(OH)D) levels during acute illness. Diagnosis confirmed via viral reverse transcriptase PCR...
Abstract Background Bowel urgency is a ‘top three’ symptom of concern to patients with ulcerative colitis (UC), but the mechanisms are unclear [1]. Determining molecular signatures bowel would reveal targetable and generate measurable endpoints for future use. Methods Clinical data from Oxford University Hospitals real world cohort were analysed. patient-reported Simple Colitis Activity Index (SCCAI) scores (including scale 0-3) extracted TrueColours-IBD remote monitoring platform [2], which...
Diagnostic methods for Covid-19 have improved, both in speed and availability. Because of atypical asymptomatic carriage the virus nosocomial spread within institutions, timely diagnosis remains a challenge. Machine learning models trained on blood test results shown promise identifying cases Covid-19.To train validate machine model capable differentiating positive from negative patients using routine tests assess model's accuracy against presentations.We conducted retrospective analysis...
Metronidazole has a benign side effect profile during normal therapeutic use. An 84-year-old woman presented with recurrence of Clostridium difficile infection (CDI). She had received oral vancomycin 5 weeks ago and was prescribed metronidazole. There progressive neutropaenia from day 1 treatment. stopped on 8 prescribed. Causality assessment via Naranjo algorithm demonstrated probable adverse (8/10) in favour Very severe 16 prompted administration granulocyte colony stimulating factor...
Introduction Surgical inpatients frequently require peripherally inserted central catheters (PICCs) for parenteral feeding and administration of medication. PICCs may cause upper limb deep venous thrombosis (ULDVT), which impacts patient morbidity. We investigated the risk prevention PICC-ULDVT in hospitalised surgical inpatients. Methods conducted a retrospective analysis 168 consecutive who received PICC over same four-year period. Data from 136 additional general medical with period were...
<b>Background:</b> Malignant pleural effusions (MPE) are very common and infer a poor prognosis, with median survival of 3-12 months. The intervention chosen to manage symptomatic MPE is determined by the clinician involved, patient preferences services available. LENT score validated tool help predict mortality in those MPE. <b>Objective:</b> clinical usefulness unclear we aimed evaluate this at our district general hospital. <b>Methods:</b> We performed retrospective analysis patients who...
Abstract Purpose Focal active colitis (FAC) is a non-specific histological diagnosis of uncertain clinical significance. There potentially causal relationship between FAC and inflammatory bowel disease (IBD) in children, but this has not been adequately explored adults. We sought to evaluate whether reliable predictor developing IBD Methods 43 patients with were retrospectively identified October 2014 May 2019 reviewed using the electronic pathology database at our institution. Patients...
Abstract Background The simple clinical colitis activity index (SCCAI) is increasingly used in practice for monitoring symptoms, because it documents urgency and nocturnal stool frequency, which are excluded from other indices. question how the SCCAI relates to validated endoscopic histological indices, so that thresholds remission active disease can be defined. Methods (range 0-19) was collected real time patients with ulcerative (UC) using web-based TrueColours-IBD collated (UCEIS, 0-8)...
<h3>Introduction</h3> Liver disease is the third leading cause of premature death in England and Wales only major causes on rise. Half all diagnoses chronic liver are made when patients present to Emergency Department with decompensated disease, this late presentation incurs a poor prognosis. There has been push identify asymptomatic advanced fibrosis early prevent progression cirrhosis (NG50 Cirrhosis over 16s: assessment management. <i>NICE</i> 2016). TE increasingly used screen for risk...
Haemolysis is a rare but serious complication of cytomegalovirus (CMV) infection, described mostly in immunocompromised patients, the pathogenesis which yet to be fully elucidated. We describe case Coombs-positive haemolytic anaemia an older Caucasian immunocompetent woman after polytrauma, resulting from suspected reactivation CMV infection and secondary cold agglutinin disease. Clinicians should consider differential diagnosis adults who are admitted with significant musculoskeletal...
Abstract Background The landmark UNITI trials 1 of Ustekinumab (UST, an anti-p40IL12/23 mAb) in treating Crohn’s disease (CD) demonstrated 6-week clinical response and 44-week remission rates 38% 41% TNF experienced 52% 62.5% naive patients. Clinical may not however reflect real world experience. Methods A systematic review meta-analysis was conducted according to PRISMA guidelines assess the real-world effectiveness safety UST luminal CD based on current licensing approvals. literature...