A5008791189- Heart Failure Treatment and Management
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Sulfur Compounds in Biology
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Cardiac Ischemia and Reperfusion
- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Genomics, phytochemicals, and oxidative stress
- Hormonal Regulation and Hypertension
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Birth, Development, and Health
- RNA modifications and cancer
- Antiplatelet Therapy and Cardiovascular Diseases
University of Zurich
2021-2025
University Hospital of Zurich
2023-2025
Center for Pediatric Endocrinology Zurich
2023-2024
Center for Translational Molecular Medicine
2024
University of Pisa
2020-2024
Albanian University
2024
The escalating prevalence of metabolic and cardiometabolic disorders, often characterized by oxidative stress chronic inflammation, poses significant health challenges globally. As the traditional therapeutic approaches may sometimes fall short in managing these conditions, attention is growing toward nutraceuticals worldwide; with compounds being obtained from natural sources potential beneficial effects shown to potentially support and, some cases, replace pharmacological treatments,...
Revascularization strategies failed to improve outcome in diabetic (DM) patients with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role angiogenic response. This study investigates the chromatin remodelling modulating angiogenesis DM. RNA sequencing (RNA-seq) assays (cell migration tube formation) were performed human aortic endothelial cells (HAECs) exposed normal glucose (NG, 5 mM) or high (HG, 25 for 48h. The histone...
Methylation of non-histone proteins is emerging as a central regulatory mechanism in health and disease. The methyltransferase SETD7 has shown to methylate alter the function variety vitro; however, its heart poorly understood. present study investigates role myocardial ischaemic injury.Experiments were performed neonatal rat ventricular myocytes (NRVMs), knockout mice (SETD7-/-) undergoing ischaemia/reperfusion (I/R) injury, left (LV) samples from patients with cardiomyopathy (ICM),...
Preservation of vascular wall integrity against degenerative processes associated with ageing, fat-rich diet and metabolic diseases is a timely therapeutical challenge. The loss endothelial function leads to cardiovascular multiorgan inflammation. protective effects the H2S-donor erucin, an isothiocyanate purified by Eruca sativa Mill. seeds, were evaluated on human smooth muscle cells. In particular, erucin actions cell viability, ROS, caspase 3/7, inflammatory markers levels...
Aims: Therapeutic modulation of blood vessel growth holds promise for the prevention limb ischemia in diabetic (DM) patients with peripheral artery disease (PAD). Epigenetic changes, namely, posttranslational histone modifications, participate angiogenic response suggesting that chromatin-modifying drugs could be beneficial this setting. Apabetalone (APA), a selective inhibitor bromodomain (BRD) and extraterminal containing protein family (BET) proteins, prevents bromodomain-containing 4...
Inflammatory bowel diseases (IBDs) are chronic and multifactorial inflammatory conditions of the colonic mucosa (ulcerative colitis), characterized by increased unbalanced immune response to external stimuli. Garlic its bioactive constituents were reported exert various biological effects, including anti-inflammatory, antioxidant immunomodulatory activities. We aimed evaluate protective effects a hydroalcoholic (GHE) water (GWE) extract from Sicilian variety garlic, known as Nubia red on an...
Vascular inflammation (VI) represents a pathological condition that progressively affects the integrity and functionality of vascular wall, thus leading to endothelial dysfunction onset several cardiovascular diseases. Therefore, research novel compounds able prevent VI compelling need. In this study, we tested erucin, natural isothiocyanate H2S-donor derived from Eruca sativa Mill. (Brassicaceae), in an vivo mouse model lipopolysaccharide (LPS)-induced peritonitis, where it significantly...
Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that mammalian silent information regulator 1 (Sirt1) orchestrates myocardial metabolism, it is unknown whether its exogenous administration could avoid MCM onset. We investigated chronic treatment recombinant Sirt1 (rSirt1) halt progression.db/db mice, an established model of MCM, were supplemented...
BACKGROUND: Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is a highly prevalent and deadly condition. Histone 3 trimethylation at lysine 36 (H3k36me3)—a chromatin signature induced by the histone methyltransferase SETD2 (SET domain containing 2)—correlates changes in gene expression human failing hearts; however, its role remains poorly understood. This study investigates of cHFpEF. METHODS: Chromatin immunoprecipitation sequencing RNA were used to investigate...
<p dir="ltr">Revascularization strategies failed to improve outcome in diabetic (DM) patients with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role angiogenic response. This study investigates the chromatin remodelling modulating angiogenesis DM. RNA sequencing (RNA-seq) assays (cell migration tube formation) were performed human aortic endothelial cells (HAECs) exposed normal glucose (NG, 5 mM) or high (HG, 25 for 48h....
<p dir="ltr">Revascularization strategies failed to improve outcome in diabetic (DM) patients with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role angiogenic response. This study investigates the chromatin remodelling modulating angiogenesis DM. RNA sequencing (RNA-seq) assays (cell migration tube formation) were performed human aortic endothelial cells (HAECs) exposed normal glucose (NG, 5 mM) or high (HG, 25 for 48h....
Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic hypertension hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo®, a polyphenolic extract from Aglianico cultivar grape, rich in catechin procyanidins, was evaluated as vasoprotective, vasorelaxing, anti-hypertensive anti-coagulant agent in: cell lines, isolated vessels,...
The aim of the present study was to investigate possible protective effects a garlic hydroalcoholic extract on burden oxidative stress and inflammation occurring mouse heart specimens exposed E. coli lipopolysaccharide (LPS), which is well-established inflammatory stimulus. Headspace solid-phase microextraction combined with gas chromatography–mass spectrometry (HS-SPME/GC–MS) technique applied determine volatile fraction powder, HS-SPME conditions were optimized for each most representative...
Hydrogen sulfide (H2S) is a fundamental biological endogenous gas-mediator in the respiratory system. It regulates pivotal patho-physiological processes such as oxidative stress, pulmonary circulation, airway tone and inflammation.We herein describe design synthesis of molecular hybrids obtained by condensation several corticosteroids with different hydrogen releasing moieties.All molecules are characterized for their ability to release H2S both via amperometric approach using fluorescent...
Hydrogen sulfide (H2S) is a gasotransmitter deeply involved in cardiovascular homeostasis and implicated the myocardial protection against ischemia/reperfusion. The post-translational persulfidation of cysteine residues has been identified as mechanism through which H2S regulates plethora biological targets. Erucin (ERU) an isothiocyanate produced upon hydrolysis glucosinolate glucoerucin, presents edible plants Brassicaceae family, such Eruca sativa Mill., it emerged slow long-lasting...
OBJECTIVE Long noncoding RNAs (lncRNAs) are involved in diabetogenesis experimental models, yet their role humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes older adults. RESEARCH DESIGN AND METHODS A preselected panel of was measured serum individuals without (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. second and 90) used to validate our...