XU Zhong-yuan

ORCID: 0000-0003-1759-9665
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About
Contact & Profiles
Research Areas
  • Chinese history and philosophy
  • Single-cell and spatial transcriptomics
  • Legal principles and applications
  • Legal Education and Practice Innovations
  • Cancer-related molecular mechanisms research
  • Gene expression and cancer classification
  • Translation Studies and Practices
  • Asian Culture and Media Studies
  • Comparative and International Law Studies
  • Conflict of Laws and Jurisdiction
  • Educational Technology and Pedagogy
  • Law and Political Science
  • Extracellular vesicles in disease
  • Linguistic, Cultural, and Literary Studies
  • Religious Studies and Spiritual Practices
  • European and International Contract Law
  • Consumer Perception and Purchasing Behavior
  • Bioinformatics and Genomic Networks
  • Cell Image Analysis Techniques
  • Linguistics and Language Analysis
  • Microfluidic and Bio-sensing Technologies
  • Innovative Educational Techniques
  • Medical Imaging and Analysis
  • Face and Expression Recognition
  • Domain Adaptation and Few-Shot Learning

Hunan University
2006-2025

Harbin Engineering University
2024

Central South University
2013

Yunnan Nationalities University
2009-2012

Yunnan University
2012

Xi'an International Studies University
2009

Soochow University
2007-2008

Renmin University of China
2007-2008

Abstract Motivation Single-cell RNA-sequencing (scRNA-seq) is widely used to reveal cellular heterogeneity, complex disease mechanisms and cell differentiation processes. Due high sparsity gene expression patterns, scRNA-seq data present a large number of dropout events, affecting downstream tasks such as clustering pseudo-time analysis. Restoring the levels genes essential for reducing technical noise facilitating However, existing imputation methods ignore topological structure information...

10.1093/bioinformatics/btad098 article EN cc-by Bioinformatics 2023-02-24

Cell-type annotation plays a crucial role in single-cell RNA-seq (scRNA-seq) data analysis. As more and well-annotated scRNA-seq reference are publicly available, automatical label transference algorithms gaining popularity over manual marker gene-based methods. However, most existing methods fail to unify cell-type with dimensionality reduction unable generate deep latent representation from the perspective of generation.In this article, we propose scSemiGAN, semi-supervised framework based...

10.1093/bioinformatics/btac652 article EN Bioinformatics 2022-10-02

10.23919/picmet64035.2024.10653222 article EN 2022 Portland International Conference on Management of Engineering and Technology (PICMET) 2024-08-04

single-cell RNA-sequencing (scRNA-seq) technology can reveal cellular heterogeneity with high throughput and resolution, facilitating the profiling of transcriptomes. However, due to some experimental factors, a large number missing values are generated in scRNA-seq data, which called dropout events, this phenomenon affects downstream analysis. Imputation is an effective denoising method, but existing imputation methods still face huge challenge: lack interpretability. In study, we propose...

10.1109/bibm55620.2022.9995463 article EN 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2022-12-06
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