A5082196676- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Zebrafish Biomedical Research Applications
- Advanced Fluorescence Microscopy Techniques
- Plant and animal studies
- Retinal Development and Disorders
- Neural dynamics and brain function
- Genetics, Aging, and Longevity in Model Organisms
- Bone health and osteoporosis research
- Neuroscience and Neural Engineering
- Reproductive Biology and Fertility
- Anomaly Detection Techniques and Applications
- Bat Biology and Ecology Studies
- Developmental Biology and Gene Regulation
- Human Pose and Action Recognition
- Biomimetic flight and propulsion mechanisms
- Silk-based biomaterials and applications
- Sperm and Testicular Function
- Bone health and treatments
- Advanced Neural Network Applications
- Plant and Biological Electrophysiology Studies
- Animal Vocal Communication and Behavior
- Insect Utilization and Effects
- Animal Genetics and Reproduction
Champalimaud Foundation
2016-2025
Howard Hughes Medical Institute
2007-2024
Janelia Research Campus
2010-2024
University of Vermont
2024
Helix (United States)
2010
Rockefeller University
2004
University of Buenos Aires
2002
Experimental Medicine and Biology Institute
1995-2002
Consejo Nacional de Investigaciones Científicas y Técnicas
1995-2002
Videos of animal behavior are used to quantify researcher-defined behaviors interest study neural function, gene mutations, and pharmacological therapies. Behaviors often scored manually, which is time-consuming, limited few behaviors, variable across researchers. We created DeepEthogram: software that uses supervised machine learning convert raw video pixels into an ethogram, the present in each frame. DeepEthogram designed be general-purpose applicable species, video-recording hardware. It...
Flexible mapping between activity in sensory systems and movement parameters is a hallmark of motor control. This flexibility depends on the continuous comparison short-term postural dynamics longer-term goals an animal, thereby necessitating neural mechanisms that can operate across multiple timescales. To understand how such body-brain interactions emerge timescales to control movement, we performed whole-cell patch recordings from visual neurons involved course Drosophila. We show leg...
Locomotion requires a balance between mechanical stability and movement flexibility to achieve behavioral goals despite noisy neuromuscular systems, but rarely is it considered how this orchestrated. We combined virtual reality tools with quantitative analysis of behavior examine Drosophila uses self-generated visual information (reafferent feedback) control gaze during exploratory walking. found that flies execute distinct motor programs coordinated across the body maximize stability....
Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential cells...
When the contrast of an image flickers as it moves, humans perceive illusory reversal in direction motion. This classic illusion, called reverse-phi motion, has been well-characterized using psychophysics, and several models have proposed to account for its effects. Here, we show that Drosophila melanogaster also respond behaviorally illusion is present dendritic calcium signals motion-sensitive neurons fly lobula plate. These results closely match predictions predominant model motion...
Abstract Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential...
Abstract Researchers commonly acquire videos of animal behavior and quantify the prevalence behaviors interest to study nervous system function, effects gene mutations, efficacy pharmacological therapies. This analysis is typically performed manually therefore immensely time consuming, often limited a small number behaviors, variable across researchers. Here, we created DeepEthogram: software that takes raw pixel values as input uses machine learning output an ethogram, set user-defined...
Summary Many animals rely on optic flow for navigation, using differences in eye image velocity to detect deviations from their intended direction of travel. However, asymmetries between the eyes are often overshadowed by strong, symmetric translational during navigation. Yet, brain efficiently extracts these course control. While sensitive-neurons have been found many animal species, far less is known about postsynaptic circuits that support such robust processing. In fly Drosophila...
The hair cells in the mammalian cochlea are of two distinct types. Inner responsible for transducing mechanical stimuli into electrical responses, which they forward to brain through a copious afferent innervation. Outer cells, thought mediate active process that sensitizes and tunes cochlea, possess negligible For every inner cell, there approximately three outer so only one-quarter directly deliver information CNS. Although this is surprising feature sensory system, occurrence similar...
Movement is the main output of nervous system. It emerges during development to become a highly coordinated physiological process essential survival and adaptation organism environment. Similar movements can be observed in morphologically distinct developmental stages an organism, but it currently unclear whether or not these have common molecular cellular basis. Here we explore this problem Drosophila, focusing on roles played by microRNA (miRNA) locus miR-iab4/8, which previously showed...
Abstract A bovine granulosa cell line (BGC‐1) has been obtained by spontaneous immortalization of primary cultures. BGC‐1 cells have retained some characteristics cultures, such as the hormonal regulation fibronectin biosynthesis. In present study we compaed and cultures in terms protein secretion, steroid metabolism, mitogenic responses to growth factors. The pattern secretion was qualitatively similar that main differences were a higher proportion relative amounts several other...
Flying insects exhibit remarkable navigational abilities controlled by their compact nervous systems. Optic flow , the pattern of changes in visual scene induced locomotion, is a crucial sensory cue for robust self-motion estimation, especially during rapid flight. Neurons that respond to specific, large-field optic patterns have been studied decades, primarily large flies, such as houseflies, blowflies, and hover flies. The best-known optic-flow sensitive neurons are tangential cells...
Abstract Course control is critical for the acquisition of spatial information during exploration and navigation, it thought to rely on neural circuits that process locomotive-related multimodal signals. However, which underlie this control, how contributes system are questions poorly understood. We used Virtual Reality examine role self-generated visual signals (visual feedback) exploratory walking in flies. Exploratory flies display two distinct motor contexts, characterized by low speed...
Abstract Flexible mapping between activity in sensory systems and movement parameters is a hallmark of successful motor control. This flexibility depends on continuous comparison short-term postural dynamics the longer-term goals an animal, thereby necessitating neural mechanisms that can operate across multiple timescales. To understand how such body-brain interactions emerge to control timescales, we performed whole-cell patch recordings from visual neurons involved course Drosophila . We...
Abstract We analyzed the presence of 3β‐Hydroxysteroid Dehydrogenase/Δ 5→4 ‐isomerase enzyme (3β‐HSD) activity, a key steroid metabolic pathway, mRNA this enzyme, and metabolism in vitro produced bovine embryos. 3β‐HSD activity was detected matured oocytes (74.4 ± 1.4%), 1‐cell (72.9 6.1%), 2‐cell (61.8 7.4%), 8‐cell (50 5%), morulae (50.8 2.6%), blastocysts (94.4 3%), hatched (100 0%) meanwhile 4‐cell stage showed significant reduction (16.7 4.7%). When total embryonic RNA different stages...