A5089466379- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Mycorrhizal Fungi and Plant Interactions
- Circadian rhythm and melatonin
- Nematode management and characterization studies
- Plant-Microbe Interactions and Immunity
- Gut microbiota and health
Rice University
2024
Huazhong Agricultural University
2019-2022
University of Massachusetts Chan Medical School
2021
C . elegans is a free-living nematode that widely used as small animal model for studying fundamental biological processes and disease mechanisms. Since the discovery of Orsay virus in 2011, also holds promise dissecting virus-host interaction networks innate antiviral immunity pathways an intact animal. primarily targets worm intestine, causing enlarged intestinal lumen well visible changes to infected cells such liquefaction cytoplasm convoluted apical border. Previous studies identified...
Abstract Microbes can enter into healthy plants as endophytes and confer beneficial functions. The entry of commensal microbes involves penetrating plant defense. Most mechanisms about overcoming defense are focused on adapted pathogens, while the mechanism involved in endophyte evades to achieve harmonious commensalism is unclear. Here, we discover a that an bacterium Bacillus subtilis BSn5 reduce stimulate defensive response by producing lantibiotic subtilomycin bind self-produced...
Abstract Pathogen recognition and the triggering of host innate immune system are critical to understanding pathogen-host interaction. Cellular surveillance systems have been identified as an important strategy for identification microbial infection. In present study, using Bacillus thuringiensis - Caenorhabditis elegans a model, we found approach sense pathogens. We report that Cry5Ba, typical pore-forming toxin, caused mitochondrial damage energy imbalance by potassium ion leakage, instead...
Abstract Pathogen recognition and triggering pattern of host innate immune system is critical to understanding pathogen-host interaction. It generally accepted that the microbial infection can be recognized by via pattern-triggered immunity (PTI) or effector-triggered (ETI) responses. Recently, non-PRR-mediated cellular surveillance systems have been reported as an important supplement strategy PTI ETI However, mechanism how sense pathogens trigger responses largely unknown. In present...
Abstract Pathogen recognition and triggering pattern of host innate immune system is critical to understanding pathogen-host interaction. Cellular surveillance systems have been reported as an important strategy for the identification microbial infection. In present study, using Bacillus thuringiensis - Caenorhabditis elegans a model, we found new approach sense pathogens. We report that produced Cry5Ba, classical PFTs, leading mitochondrial damage energy imbalance by causing potassium ion...