A5012709409- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- T-cell and B-cell Immunology
- Glutathione Transferases and Polymorphisms
- T-cell and Retrovirus Studies
- Bladder and Urothelial Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Respiratory viral infections research
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Animal Disease Management and Epidemiology
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Galectins and Cancer Biology
- Genomics, phytochemicals, and oxidative stress
Université de Lille
2014-2016
Institut Pasteur de Lille
2014-2016
Centre National de la Recherche Scientifique
2012-2016
Institut de Biologie de Lille
2013-2014
Institut Gustave Roussy
2014
Onco Lille
2014
Mécanismes de Tumorigenèse et Thérapies Ciblées
2012
Institut Pasteur
2012
University of Sousse
2011
Regulatory T cells (Treg) and tumor-exosomes are thought to play a role in preventing the rejection of malignant patients bearing nasopharyngeal carcinoma (NPC). Treg recruitment by exosomes derived from NPC cell lines (C15/C17-Exo), isolated patients' plasma (Patient-Exo), CCL20 were tested vitro using Boyden chamber assays vivo xenograft SCID mouse model (n = 5), both presence absence anti-CCL20 monoclonal antibodies (mAb). Impact these (NPC-Exo) on phenotype function was determined...
Summary Epstein–Barr Virus ( EBV ) is present in the neoplastic cells of around 20–30% patients with Hodgkin Lymphoma HL ). Although, an immunosuppressive environment currently described patients, little known concerning regulatory mechanism induced by proteins expression tumour cells. This study aimed to investigate association between Type 1 (Tr1) and tissue positivity patients. Transcriptomic analysis both ‐positive ‐negative tumours showed that infection increased gene Tr1‐related...
H-1 parvovirus (H-1 PV), a rodent autonomous oncolytic parvovirus, has emerged as novel class of promising anticancer agents, because its ability to selectively find and destroy malignant cells. However, probe PV multimodal antitumor potential one the major prerequisites is decipher direct interplay with human immune system, so prevent any risk impairment.Non activated peripheral blood mononuclear cells (PBMCs) are not sensitive cytotoxic effect. virus impairs both PBMC proliferation...
Epstein-Barr virus (EBV) is associated with several malignant diseases that can be distinguished by their patterns of viral latent gene expression. We developed here an original peptidic approach to favor the induction a specific CD4+ T-cell response against EBV latency II malignancies (Hodgkin's lymphoma, nasopharyngeal carcinoma, T/NK lymphoma). Previously, we selected 6 peptides derived from nuclear antigen-1, membrane proteins (LMP)-1, and LMP-2 highly promiscuous for major...
Hepatitis C virus (HCV) is an important causative agent of liver disease, but factors that determine the resolution or progression infection are poorly understood. In this study, we suggested existence immunosuppressive mechanisms, supported by regulatory T cells and especially cell 1 subset (Tr1), may explain impaired immune response during thus fibrosis aggravation to hepatocellular carcinoma (HCC). Using quantitative real-time PCR, investigated intra-hepatic presence Tr1 in biopsies from...
Bladder cancer is among the most frequently diagnosed cancer. Tobacco smoking exposures involving nitrosamines and aromatic amines are main cause of bladder Although cigarette consumption has gradually decreased, an increased incidence was registered males Tunisian for last two decades. A similar lung adenocarcinoma males. Epidemiological results suggest that changes in may be The relationship between CYP1A2 enzyme activities, a key activation carcinogens, risk investigated. Variations CYP1...
A1 Hope and despair in the current treatment of nasopharyngeal cancer IB Tan I1 NPC international incidence risk factors Ellen T Chang I2 Familial carcinoma use biomarkers Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien I3 Genetic susceptibility for sporadic familial NPC: recent findings Allan Hildesheim I5 environmental Southeast Asia James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena...