A5064836400- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Cerebrovascular and Carotid Artery Diseases
- Cutaneous Melanoma Detection and Management
- Corneal Surgery and Treatments
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- melanin and skin pigmentation
- Nanoplatforms for cancer theranostics
- Systemic Lupus Erythematosus Research
- Veterinary Oncology Research
- Cancer Genomics and Diagnostics
- Bartonella species infections research
- Drug-Induced Ocular Toxicity
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Knee injuries and reconstruction techniques
- Ocular Infections and Treatments
- Chemotherapy-related skin toxicity
- Retinopathy of Prematurity Studies
University of Lisbon
2016-2024
McGill University
2018-2024
Hospital de São José
2024
University of Coimbra
2024
Centro Hospitalar de Lisboa Central
2015-2021
Hospital Santo António dos Capuchos
2018-2019
Hospital de Santo António
2018
Escola Secundária Quinta do Marquês
2011
Hospital Curry Cabral
1998
To compare choroidal thickness (CT) between diabetic patients without retinopathy and a nondiabetic group. explore how CT relates to disease duration, mean arterial pressure, glycemia, glycosylated hemoglobin, intraocular ocular pulse amplitude.Choroidal was assessed using spectral-domain optical coherence tomography enhanced depth mode at 13 locations (subfoveal 3 measurements 500 μm apart in 4 directions-nasal, temporal, superior, inferior). Linear regression models were used.One hundred...
The purpose of this study was to measure and compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), without AD, elderly patients.CT measured manually in 13 locations at 500-μm intervals a horizontal vertical section from the fovea. Linear regression models were used analyze data.Fifty diagnosis AD (73.1 years), 152 (71.03 50 (82.14 years) included. In patients, CT significantly thinner all (P < .001-comparing age-match group), comparing group, more...
Uveal melanoma (UM) is the most common intraocular tumor in adults. Despite good primary control, up to 50% of patients develop metastasis, which lethal. UM often presents asymptomatically and usually diagnosed by clinical examination imaging, making it one few cancer types without a biopsy. Hence, alternative diagnostic tools are needed. Circulating DNA (ctDNA) has shown potential as liquid biopsy target for screening monitoring. The aim this study was evaluate feasibility utility ctDNA...
Uveal melanoma is the most common intraocular tumor in adults. Our group has previously developed a human uveal animal model; however, adverse effects caused by immunosuppressive agent, cyclosporine A, prevented animals from surviving more than 12 weeks. In this study, we tested multiple A doses over an extended disease course up to 20 weeks, providing complete clinical imaging of tumors, histopathological analysis and liquid biopsy biomarker analysis. Twenty albino rabbits were divided into...
The authors report a case of an orbital metastasis from occult breast carcinoma. A 66-year-old woman presented with growing left tumour. Orbital CT scan was consistent lymphoma. However, ocular pathology revealed small neoplastic cells showing 'indian file pattern' suggestive metastatic carcinoma and immunohistochemistry positive for CK7, CK CAM5.2 oestrogen receptor. systemic evaluation then performed mammogram, ultrasound MRI considered normal. An exhaustive multiple bone lesions, right...
Leber’s hereditary optic neuropathy (LHON) is an of mitochondrial inheritance, characterised by incomplete penetrance and variable expressivity. Typically, young male patients present with sequential, severe, rapidly progressive loss central vision, characteristic funduscopic findings. However, LHON may at any age, in both genders, fundus examination be normal. Evidence has emerged to support the role environmental factors triggering LHON, disrupting normal mechanisms function. We two...
Internal carotid artery dissection (ICAD) is caused by the disruption of tunica intima, with formation an intramural haematoma that can cause stenosis or occlusion artery's lumen, leading to reduced blood flow and secondary thrombus formation. Up two-thirds patients ICAD show ophthalmological symptoms signs, which are, frequently, first manifestations this clinical condition, often preceding for weeks neurological signs cerebral infarction. Central retinal (CRAO) a rare complication ICAD,...
Purpose To evaluate retinal layers thickness in diabetic patients without retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT). correlate with disease duration, systemic blood pressure (BP), glycemia, glycosylate haemoglobin (HbA1c), intraocular (IOP) and ocular pulse amplitude (OPA). Methods Prospective, observational case–control study. A total of 175 eyes from (125 DR; 50 healthy controls) were recruited the outpatient clinic a tertiary center. complete...
In just one hundred years, the world has been through five pandemics. Lessons of past have not prevented a new virus from being responsible for fifth wave deaths worldwide, even with scientific advances and rapid response societies that, most part, anticipated political economic response. A century after end Spanish Flu (1918/19), in December 2019, watched beginning second pandemic 21st century, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-2...
Purpose To evaluate choroidal thickness (CT) in diabetic patients without retinopathy (DR) using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). correlate CT with disease duration, systemic blood pressure (BP), glycemia, intraocular (IOP) and ocular pulse amplitude (OPA). Methods Prospective, observational case-control study. A complete ophthalmological examination was performed (visual acuity, refraction, Goldmann applanation dynamic contour tonometries,...
Purpose Compare choroidal thickness (CT) between diabetic patients without retinopathy (DR) and a non‐diabetic group. Explore how CT relates to disease duration, mean arterial pressure (MAP), glycaemia, glycosylated haemoglobin (HbA1c), intraocular ocular pulse amplitude (OPA). Methods In this cross‐sectional study, was assessed using SD‐OCT (Spectral Domain Optical Coherence Tomography) enhanced depth mode at 13 different locations (subfoveal 3 measurements 500 μ m apart in all 4 directions...
Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication and assessment individual metastatic risk, but can be used for diagnosis selected cases. The importance precise information is paramount selecting adequate surveillance protocols, patient counseling, optimization treatment strategies. However, intratumoral heterogeneity sample representativity are major concerns interfere with correct prediction patient’s prognosis. We report a series cases UM distinct...
Purpose To evaluate the thickness of macular retina and determine which retinal layers are most affected by retrochiasmal visual pathways lesions. Methods Mean utilizing automated intraretinal layer segmentation spectral domain optical coherence tomography scans was performed in 40 eyes patients with lesions compared 60 control subjects. Multiple linear regression analysis used to relationship between follow-up, age gender. Results Ganglion cell inner plexiform thinner temporal hemiretina...
Purpose Chronic hyperglycemia is responsible for vascular and neurodegenerative retinal changes in diabetic patients. However, other eye structures have been also associated with changes, such as corneal biomechanics lens thickness. The author's objective was to analyze the accommodative process – crystalline structural change pupillary diameter based on Anterior Segment Optical Coherence Tomography (AS‐OCT). Methods Prospective case‐control study. anterior chamber parameters were studied...