A5023460838- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Dam Engineering and Safety
- GNSS positioning and interference
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Synthesis and Biological Evaluation
- Geodetic Measurements and Engineering Structures
- Diet, Metabolism, and Disease
- Computational Drug Discovery Methods
Universidade Federal de Goiás
2021-2022
Universidade Estadual de Campinas (UNICAMP)
2019-2022
Intrauterine growth restriction (IUGR) due to fetal exposure glucocorticoid excess results in metabolic inflexibility and hepatic steatosis upon nutritional stress during adulthood. We previously demonstrated that rats born dexamethasone (DEX)-treated mothers developed when exposed 10% fructose solution adult life. Persistent triacylglyceride (TAG) accumulation the liver, turn, is a feature of non-alcoholic fatty liver disease (NAFLD), which serves as risk factor for steatohepatitis (NASH)...
Anxiety and depression are common mental disorders affecting millions of people worldwide. Unsatisfactory clinical outcomes with the use available pharmacological interventions among some patients demand newer drugs proven efficacy, safety, tolerability profile. In this study, LQFM211, LQFM213, LQFM214 were designed from piperazine scaffold administered orally in mice. These mice later evaluated open field, elevated plus maze, forced swimming tests to assess exploratory, anxiolytic,...
In the present study we investigated participation of hepatic peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) in metabolic programming newborn rats exposed utero to dexamethasone (DEX). On 21st day life, fasted offspring born DEX-treated mothers displayed increased conversion pyruvate into glucose with simultaneous upregulation PEPCK (phosphoenolpyruvate carboxykinase) and G6Pase (glucose-6-phosphatase). Increased oxidative phosphorylation, higher ATP/ADP ratio...
Background: Pharmacological treatments for mental disorders, such as anxiety and depression, present several limitations adverse effects. Therefore, new pharmacotherapy with anxiolytic antidepressant potential is necessary, the study of compounds capable interacting more than one pharmacological target may provide therapeutic options. Objectives: In this study, we proposed design, synthesis a compound, 2-(4-((1- phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethyl acetate (LQFM192), evaluation...