A5022084529- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Erythrocyte Function and Pathophysiology
- DNA and Nucleic Acid Chemistry
- Marine Biology and Environmental Chemistry
- Spectroscopy and Quantum Chemical Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Surfactants and Colloidal Systems
- Protein Interaction Studies and Fluorescence Analysis
- Blood properties and coagulation
- Organometallic Compounds Synthesis and Characterization
- Advanced Drug Delivery Systems
- Protein Structure and Dynamics
- Corrosion Behavior and Inhibition
- Vitamin D Research Studies
- Nanoparticles: synthesis and applications
- Nanopore and Nanochannel Transport Studies
- Electrostatics and Colloid Interactions
- Ion channel regulation and function
- Polymer Surface Interaction Studies
- Vitamin C and Antioxidants Research
- Force Microscopy Techniques and Applications
- Photoreceptor and optogenetics research
Wrocław University of Science and Technology
2013-2023
AGH University of Krakow
2016-2023
University of Agriculture in Krakow
1997-2021
Institute of Macromolecular Chemistry
2015
Institute of Physics
2000-2007
Wroclaw Research Centre EIT+ (Poland)
2007
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2006
Czech Academy of Sciences, Institute of Physics
2006
University of Wrocław
2004-2005
Roswell Park Comprehensive Cancer Center
1991-2000
Lipid bilayers are active participants in many crucial biological processes. They can be observed different phases, liquid and solid, respectively. The phase is predominant systems. solid phase, both crystalline gel under investigation due to its resilience mechanical stress tight packing of lipids. properties lipids affect their dynamics, therefore influencing the transformation cell plasma endomembrane. Mechanical lipid also an important parameter design production supramolecular...
The biophysical properties of liposome surfaces are critical for interactions between lipid aggregates and macromolecules. Liposomes formed from cationic lipids, commonly used to deliver genes into cells in vitro vivo, an example such a system. We apply the fluorescence solvent relaxation technique study structure dynamics fully hydrated liquid crystalline bilayers composed mixtures dioleoyltrimethylammoniumpropane (DOTAP) neutral dioleoylphosphatidylcholine (DOPC). Using three different...
The effect of lipid oxidation on water permeability phosphatidylcholine membranes was investigated by means both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation pores followed a significant enhancement observed. molecules oxidized phospholipids facilitate pore formation subsequently stabilize in the membrane interior. A wide range ratios, from 15 to 100 mol%, considered. degree found strongly influence time needed for opening pore. In simulations,...
Vitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, efficient delivery critical maintenance body homeostasis. pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In paper, we present new liposomal formulation vitamin free harmful organic solvents. The was quantitatively characterized with respect to chemically composition nano-structuring. accessibility cells from evaluated using evidence derived...
Mechanical properties of a lipid bilayer are parameters determined mainly for giant unilamellar vesicles (GUVs). It is not clear if values obtained on the GUV model can be directly translated to submicron large (LUVs). This ambiguity major obstacle in exploring effect mechanics membrane associated processes and effectiveness liposome-based targeted drug delivery systems. In presented work extrusion, which common method prepare LUVs, was used study liposomes preparation stability upon...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescent probes of electrostatic potential 1 nm from the membrane surfaceAnthony P. Winiski, Moises Eisenberg, Marek Langner, and Stuart McLaughlinCite this: Biochemistry 1988, 27, 1, 386–392Publication Date (Print):January 1988Publication History Published online1 May 2002Published inissue January 1988https://pubs.acs.org/doi/10.1021/bi00401a058https://doi.org/10.1021/bi00401a058research-articleACS PublicationsRequest reuse permissionsArticle...
Growth-inhibition of GW-77 human colonic tumors growing in hamster cheek pouches was found to be proportional the duration heating exposed by 4 °C with short-wave diathermy. A maximal tumor growth-inhibition 35 per cent resulted from administration a daily 30 min. period repeated on 7 consecutive days. Further, hyperthermia left pouch contralateral, presumably normothermic, tumors, thus causing us question whether has abscopal antitumor effects.
Despite recent advancements in medicine, lung cancer still lacks an effective therapy. In the present study we have decided to combine superparamagnetic iron oxide nanoparticles (SPION) with solid lipid microparticles develop novel, stimuli-sensitive drug carriers that increase bioavailability of anticancer (paclitaxel — PAX) through guided accumulation directly at tumour site and controlled delivery. SPION PAX-loaded (MPs) were fabricated from lauric acid (LAU) a mixture myristic palmitic...
Abstract The antioxidative activity of three anthocyanin pigments, extracted from the fruits chokeberry, honeysuckle and sloe, were studied. Lipid oxidation in liposome membrane, induced by UV radiation, was evaluated with a thiobarbituric acid-reactive substances assay. antioxidant efficiency studied compounds follows this sequence: chokeberry > sloe honeysuckle. extract concentrations at which 50% reduction phosphatidylcho line observed, respectively: 48, 54 60 mg/1. end products lipid...
The changing environment and modified lifestyles have meant that many vitamins minerals are deficient in a significant portion of the human population. Therefore, supplementation is viable nutritional approach, which helps to maintain health well-being. efficiency highly hydrophobic compound such as cholecalciferol (logP > 7) depends predominantly on formulation. To overcome difficulties associated with evaluation pharmacokinetics cholecalciferol, method based short time absorption data...