Kombucha tea is a refreshing beverage that produced from the fermentation of leaves. In this study, kombucha was prepared using 1% green tea, oolong and black 10% sucrose with acetic acid bacteria yeast. The pH values were found to be in range 2.70-2.94 at 15 days fermentation. lowest value 2.70 recorded tea. total acidity highest by 16.75 g/L it still maintained after heat treatment boiling autoclaved. Six organic acids: glucuronic, gluconic, D-saccharic 1,4-lactone, ascorbic, acetic,...

The white mulberry (Morus alba L.) is widely used as a medicinal plant in Asia. In this study, the bioactive compounds of ethanolic extracts leaves from Sakon Nakhon and Buriram cultivars were evaluated. cultivar showed highest total phenolic content 49.68 mg GAE/g extract antioxidant activities 4.38 extract, 4.53 TEAC/g 92.78 FeSO4/g using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,20-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) (ABTS), ferric reducing power (FRAP) assays, respectively....

Herpes simplex virus (HSV) is known to cause cold sores and various diseases in humans. Importantly, HSV infection can develop latent recurrent infections, it also inflammation. These infections are difficult control, effective treatment of the disease remains a challenge. Thus, search for new antiviral anti-inflammatory agents necessity. Melittin major peptide that present venom honeybee. It possesses number pharmacological properties. In this study, effects melittin peptides from A....

Dengue virus (DENV) infection causes mild to severe illness in humans that can lead fatality cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, development an anti-DENV urgently required. Cordycepin (3′-deoxyadenosine), which a major bioactive compound Cordyceps (ascomycete) fungus has been used centuries Chinese traditional medicine, was reported exhibit antiviral activity. However, activity cordycepin unknown. We hypothesized exerts and that, as...

The fruit of mulberry trees (Morus sp.), mulberries, are traditionally utilised as a nutritional food and provide health benefits well skin nourishment in Thailand. White mulberries alba L.) from Chiang Mai Mae Hong Son provinces were evaluated for their antioxidant antibacterial activities. activities the total phenolic, flavonoid anthocyanin content aqueous ethanolic extracts determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) (ABTS)...

Probiotics are increasingly used as functional food ingredients. The objectives of this study were to isolate and characterise probiotic bacteria from dairy fermented foods use a selected strain for the production chèvre cheese. Tolerance acid (pH 2.0) bile salt (0.4% (w/v)) first investigated, then other properties determined. Out 241 isolates, 35 showed high tolerance salt, 6 chosen further characterisation. They Lactobacillus plantarum L. fermentum, possessed antibacterial activities...

Royal jelly is a nutritious substance produced by the hypopharyngeal and mandibular glands of honeybees. possesses many attractive beneficial properties which make it an ideal component in medical pharmaceutical products. The antibacterial, antioxidant, anti-inflammatory activities royal from honeybees (Apis mellifera) were determined this study. Moreover, total phenolic flavonoid contents also evaluated. effects on growth inhibition against skin pathogenic bacteria, including Cutibacterium...

Propolis is a natural substance and consists of bioactive compounds, which gives it antioxidant antimicrobial properties. However, the use propolis limited by low solubility in aqueous solutions. Thus, nanoparticles may be likely to accomplish enhanced delivery poorly water-soluble phytomedicine. The aim present study was fabricate evaluate biological activity ethanolic extract propolis-loaded poly(lactic-co-glycolic acid) (EEP-NPs). EEP-NPs were prepared using oil-in-water (o/w)...

Zea mays L. Poaceae stigma (corn silk, CS) is a byproduct of agricultural waste and used as traditional herb in many countries. CS rich chemical compounds known to benefit human health also remedy for infectious diseases has anti-proliferative effects on cancer cell lines. In the present study, extract been evaluated its antioxidant, antibacterial, anti-tyrosinase activities phytochemical composition. The higher total phenolic flavonoid contents were found ethanolic corn silk (CSA), at 28.27...

Microalgae, especially spirulina, have been globally used as a food supplement due to their rich protein content, safety for human consumption, and provision of enhanced immunomodulatory capabilities. There are, however, few reports that investigated the properties spirulina hydrolysate. Consequently, this study aims optimize best extraction techniques hydrolysate characterize its antioxidant activities immunomodulation in vitro . The results indicated with Flavourzyme alkaline after...

Spirulina, a cyanobacterial biomass, is renowned for its high protein content and bioactive compounds, making it promising candidate health-promoting applications. This study explores the ultrasound-assisted deep eutectic solvent (DES) extraction technique isolating antioxidants anticancer proteins from Spirulina aiming to enhance efficiency preserve bioactivity. The process was optimized using response surface methodology (RSM), varying parameters such as biomass concentration, sonication...

Combination treatment enhances the therapeutic potential for diabetes, particularly patients with severe complications. Combining standard drugs alternative bioactive compounds provides a promising option long-term treatment, given high safety profile of substances. Objective in this study, we aimed to evaluate synergistic effects metformin and Clinacanthus nutans (Burm. f.) Lindau (CN) on glucose metabolism renal dysfunction parameters type 2 diabetic rat model. Male Wistar rats were fed...

Cordyceps militaris has been used for treating various diseases, as well maintaining good overall health. The antibacterial properties of the C. fruiting body and substrate, cultured in Chiang Mai (sample A B) Rai C), Thailand, were investigated this study. aqueous ethanolic extracts exhibited activities against Staphylococcus aureus, Pseudomonas aeruginosa, Cutibacterium acnes methicillin-resistant S. aureus (MRSA) with MIC/MBC ranging from 3.91 to 31.25 mg/mL. substrate sample B also...

Traditional kombucha tea was prepared by black leaves before fermentation with symbiotic microorganisms for 15 days. In this study, through a combination medicinal plant extracts of T. catappa (KT) and A. marmelos (KA) to enhance number beneficial aspects. The results revealed that the phenolics, flavonoids, antioxidants six organic acids, namely glucuronic, gluconic, D-saccharic acid 1,4-lactone (DSL), acetic, ascorbic, succinic in combined resulted production substances greater properties...

Abstract Kombucha tea is a traditional beverage originating from China and has recently gained popularity worldwide. produced by the fermentation of leaves characterized its beneficial properties varied chemical content during process, which includes organic acids, amino vitamins, minerals, other biologically active compounds. often consumed as health drink to combat obesity inflammation; however, bioactive effects kombucha have not been thoroughly researched. In this study, we reveal...

Periodontal disease is more prevalent in patients with diabetes, and it has a negative impact on their quality of life. Inhibiting the infection inflammation processes that cause periodontal can reduce severity chances serious complications. In this study, we aimed to demonstrate effectiveness Clinacanthus nutans extract reducing gingival fibroblast cells induced by Porphyromonas gingivalis lipopolysaccharide (LPS). Stimulation LPS under high-glucose conditions led increased compared...

Lung cancer remains one of the most lethal malignancies, often diagnosed at advanced stages, leading to limited treatment options. Thus, identifying natural products with potent anti-cancer activity is crucial for improving outcomes. While melittin from Apis mellifera (Mel-AM) has been extensively studied, florea (Mel-AF), a bee species native Southeast Asia, relatively underexplored. These peptides were comparatively investigated against non-small cell lung (NSCLC) lines, A549, NCI-H460,...

Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization one approach to enhance tumor cell susceptibility cytotoxicity that can be used in combination with immunotherapy achieve therapeutic efficiency. Cordycepin, bioactive compound extracted from some Cordyceps spp. has been reported effectively inhibit growth, however, the mechanism of its activity enhances unknown. In present study, we investigated potency cordycepin sensitize lethal...

Cyanobacteria are rich in phytochemicals, which have beneficial impacts on the prevention of many diseases. This study aimed to comprehensively characterize phytochemicals and evaluate multifunctional bioactivities ethanolic extract cyanobacterium Leptolyngbya sp. KC45. Results found that mainly contained chlorophylls, carotenoids, phenolics, flavonoids. Through LC-ESI-QTOF-MS/MS analysis, 38 phenolic compounds with promising were discovered, a higher diversity flavonoids was among...

Aims To investigate the biological activity of Thai medicinal plant extracts and their active substances on inhibition growth transcription colibactin genes colibactin-producing Escherichia coli, effect pathogenesis from toxin including transient infections colibactin-induced DNA damage. Methods Results Among 16 plants examined, aqueous Terminalia catappa, Psidium guajava Sandoricum koetjape demonstrated against E. coli ATCC 25922, which is known to produce toxin. These contain phytochemical...

Rice is one of the most important food crops in many countries, with nutritional value and health benefits. In this study, ethanolic aqueous extracts red jasmine rice from Chiang Mai, Thailand were examined for their anthocyanins phenolic contents. The antioxidant antiviral activity against herpes simplex virus type 1 (HSV-1) 2 (HSV-2), as well anticancer activity, investigated. total content 708.03 ± 11.56 mg Cy-3-glc equivalent/g extract, determined was higher than extract. However,...

Harmful algal blooms impact human welfare and are a global concern. Sargassum spp., type of algae or seaweed that can potentially bloom in certain regions the sea around Thailand, exhibits noteworthy electron capacity as sole reducing stabilizing agent, which suggests its potential for mediating nanoparticle composites. This study proposes an eco-friendly microwave-assisted biosynthesis (MAS) method to fabricate silver nanoparticles coated with aqueous extract (Ag/AgCl-NPs-ME)....