A5035730849- Synthesis and biological activity
- Computational Drug Discovery Methods
- Enzyme Catalysis and Immobilization
- Cholinesterase and Neurodegenerative Diseases
- biodegradable polymer synthesis and properties
- Free Radicals and Antioxidants
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- Electrochemical sensors and biosensors
- Electrospun Nanofibers in Biomedical Applications
- Analytical Chemistry and Chromatography
- Toxin Mechanisms and Immunotoxins
- Carbon dioxide utilization in catalysis
- Protein Structure and Dynamics
- Inorganic and Organometallic Chemistry
- Synthesis and Biological Evaluation
- Phytochemicals and Antioxidant Activities
- Metal complexes synthesis and properties
- Genomics, phytochemicals, and oxidative stress
- Insect Resistance and Genetics
- Protein Interaction Studies and Fluorescence Analysis
- ATP Synthase and ATPases Research
- Biofuel production and bioconversion
Marmara University
2016-2025
Abstract Poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAA) nanofibers with the fiber diameter of 100–150 nanometers were fabricated by electrospinning. PVA/PAA crosslinked heat‐induced esterification and resulting nanofiber mats insoluble in water. α‐Amylase was covalently immobilized onto surfaces via activation amine groups presence 1,1′‐carbonyldiimidazole. The α‐amylase has more resistance to temperature inactivation than that free form showed maximum activity at 50°C. pH‐dependent...
Introduction: In this study, we report on the synthesis and characterization of new silicon (IV) phthalocyanine compounds (SiPcs) axially substituted with coumarin-linked derivatives, designed for potential application in photodynamic therapy (PDT) due to their photophysical properties. Method: Characterization was carried out using FT-IR, UV-Vis, MALDI-TOF-MS, 1H NMR spectroscopy. dimethyl sulfoxide (DMSO), SiPcs produced singlet oxygen quantum yields 0.17 0.19, assessed by DPBF quenching...
In this study, 7,8-dihydroxy-3-(4-methylphenyl) coumarin (DHMPC), a new derivative, was tested for the first time to determine whether it had any antioxidant and lipid lowering effects. Hypercholesterolemia induced by feeding rats with high cholesterol diet 17 days. The effects of DHMPC were compared those hesperidin (CAS 520-26-3) rutin 153-18-4), which have been pharmacologically determined as potential agents. significantly decreased total levels but not efficient hesperidin. When ratios...
Abstract Chemically synthesized polyaniline (PANI) was used as polymeric support for xylanase immobilization. The polymer first activated with glutaraldehyde and then successfully immobilized. Xylanase bound characterized using FTIR. optimum pH of the immobilized enzyme at 5, which shifted 1.0 unit to acidic region when compared free enzyme. Thermal stability improved characteristic properties native enzyme, such kinetic activity, reusability storage were also studied temperature....
Abstract Cardiovascular diseases are one of the primary causes deaths worldwide, and development atherosclerosis is closely related to hypercholesterolemia. As reduction low‐density lipoprotein cholesterol level critical for treating these diseases, inhibition 3‐hydroxy‐3‐methyl‐glutaryl coenzyme A (HMG‐CoA) reductase, which essentially responsible biosynthesis, stands out as a key solution lower plasma levels. In this study, we synthesized several dihydroxycoumarins investigated their...
α‐amylase was covalently immobilized on functionalized polyimide (PI) membranes via glutaraldehyde (GA) activation. 3,3′,4,4′‐Benzophenonetetracarboxylic acid dianhydride (BTDA) and 4,4′‐oxydianline (4,4′‐ODA) based were obtained thermal imidization. Free amine groups the surface of generated by amination reaction polyimides with hexamethylenediamine (HMDA). Surface‐aminated subjected to enzyme immobilization after GA Immobilization efficiency activity examined at various pH (3.0–8.0)...
This study presents 37 new antioxidant coumarin derivatives and strategies for structural modification to improve their activities, the main ferric-reducing power (FRAP) assay used evaluate properties generation of validated quantitative structure–activity (antioxidant activity) relationship (QSAR) models. In an attempt generate QSAR models, structures all in data set were fully optimized by semi-empirical PM6 method using SPARTAN 10 software. Descriptors calculated DRAGON 6.0 Multiple...
UV-cured epoxy-based polymeric film was prepared from glycidyl methacrylate, trimethylolpropane triacrylate, and poly(ethylene glycol) methylether acrylate. 2-hydroxy-2- methylpropiophenone used as photo initiator. Covalent binding through epoxy groups employed to immobilize β-galactosidase Escherichia coli onto this film, immobilization conditions were optimized by the response surface methodology. ATR-Fourier transform infrared (FTIR) scanning electron microscopy (SEM) analysis carried out...
Glutathione S ‐transferases (EC: 2.5.1.18, GSTs) are phase II detoxification enzymes that catalyze the conjugation of various electrophilic compounds to glutathione (GSH), thus usually producing less reactive and more water soluble compounds. However, there is evidence elevated expression GSTs, especially GSTP1, involved in resistance tumor cells against chemotherapeutic agents. In this study, we synthesized investigated inhibitory effects differently substituted 3‐arylcoumarin derivatives...
The ability of Archaea to adapt their membrane lipid compositions extreme environments has brought in archaeosomes into consideration for the development drug delivery systems overcoming physical, biological blockades that body exhibits against therapies. In this study, we prepared unilamellar archaeosomes, from polar fraction extracted Haloarcula 2 TK strain, and explored its potential as a vehicle. Rifampicin isoniazid which are conventional drugs tuberculosis medication were loaded...
Coumarin and their derivatives, such as biscoumarins, which are found active ingredients in a variety of drugs, possess wide range biological activities. In this paper, the inhibitory effects biscoumarin derivatives B1 B2 on monoamine oxidase (MAO) enzyme activity were studied. Their binding mechanism to bovine serum hemoglobin (BHb) albumin (BSA) was investigated using molecular docking multi-spectroscopic methods absorption, fluorescence, synchronized fluorescence spectroscopy. The...
Natural and synthetic coumarin derivatives have been shown to possess several beneficial pharmacological effects. The anticoagulation antithrombotic activities of the 4-hydroxy are well known. In this study, besides substituent phenyl p-methylphenyl were synthesized confirmed on basis their spectral data. 3-Amino-4-hydroxy coumarin, 5,7-dihydroxy-4-phenyl 7,8-dihydroxy-3-(4-methylphenyl)coumarin tested in rats determine whether they had any effect vitamin K inhibition by investigating...
A series of arylcoumarin derivatives and two novel biscoumarin were investigated for their human recombinant glutathione S-transferase P1-1 (GSTP1-1) enzyme inhibitory activities the first time. 4-(3,4-Dihydroxyphenyl)-6,7-dihydroxycoumarin (compound