A5070434368- Ferroptosis and cancer prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Barrier Structure and Function Studies
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
China Medical University
2018-2023
Microvascular basement membrane (BM) plays a pivotal role in the interactions of astrocyte with endothelium to maintain blood-brain barrier (BBB) homeostasis; however, significance and precise regulation endothelial cell-derived BM component BBB remain incompletely understood. Here, we report that conditional knockout Atg7 cells (Atg7-ECKO) leads astrocyte-microvascular disassociation brain. Our results reveal astrocytic endfeet detachment from microvessels leakage Atg7-ECKO mice....
Ischemic strokes often result in cerebral injury due to ischemia/reperfusion (I/R). Although the local inflammatory responses are known play a primary role brain I/R injury, underlying mechanism remains unclear. In current study, we investigated effect of endothelial Atg7 (autophagy related 7) depletion acute induced by ischemia and reperfusion. Endothelial knockout mice (Atg7 eKO) was found significantly attenuate both infarct volume neurological defects when compared controls. fact, were...