A5059801042- Glioma Diagnosis and Treatment
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Sensor and Energy Harvesting Materials
- Neurobiology and Insect Physiology Research
- Cancer, Hypoxia, and Metabolism
- Conducting polymers and applications
- Ophthalmology and Eye Disorders
- Motor Control and Adaptation
- Zebrafish Biomedical Research Applications
- Neural Networks and Applications
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- NF-κB Signaling Pathways
- Health disparities and outcomes
- MRI in cancer diagnosis
- interferon and immune responses
- Mitochondrial Function and Pathology
- Ocular Oncology and Treatments
- Endoplasmic Reticulum Stress and Disease
- Ocular Disorders and Treatments
- Adolescent Sexual and Reproductive Health
Terumo (United States)
2024
Drexel University
2022-2024
Health and Human Development (2HD) Research Network
2023
Cincinnati Eye Institute
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018-2019
Southern Utah University
2012
Babraham Institute
1993-2011
Walton Centre
2004-2010
University of Liverpool
2004-2010
Clatterbridge Cancer Centre NHS Foundation Trust
2005-2006
Nongenomic response pathways mediate many of the rapid actions steroid hormones, but mechanisms underlying such responses remain controversial. In some cases, cell-surface expression classical nuclear receptors has been suggested to these effects, but, in a few instances, specific G-protein-coupled (GPCRs) have reported be responsible. Here, we describe activation novel, neuronally expressed Drosophila GPCR by insect ecdysteroids ecdysone (E) and 20-hydroxyecdysone (20E). This is first...
Ubiquitination regulates the stability and/or activity of numerous cellular proteins. The corollary is that de-ubiquitinating enzymes, which ‘trim’ polyubiquitin chains from specific substrate proteins, play key roles in controlling fundamental activities. Ubiquitin essential at several stages during activation NF-κB (nuclear factor κB), a central co-ordinator inflammation and other immune processes. known to cause degradation inhibitory molecule IκBα (inhibitor κB). In addition, TRAF...
Oligodendroglial neoplasms with the -1p/-19q genotype are more indolent longer survival and increased therapeutic responsiveness than those intact 1p/19q, but biological basis for these clinical differences is unclear. Recent research suggests that oligodendrogliomas without may be distinguished by their magnetic resonance imaging (MRI) appearance, suggesting possible in growth characteristics. This study examined relationship between histological patterns of oligodendroglial association MR...
A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-κB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, and Kilshaw, J. (2001) Biochem. 357, 617–623). One these molecules, cellular zinc finger anti-NF-κB (Cezanne), 100-kDa cytoplasmic protein, also suppressed NF-κB. Here we demonstrate Cezanne is deubiquitinating enzyme, distinct the known families deubiquitinases, Types I II. We show contains...
The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine kinase inhibition damage-induced deamidation tightly correlates with T cell transformation in vivo, although pathway remains unknown and its functional consequences unclear. show here rBcl-xL generates an iso-Asp(52)/iso-Asp(66) species unable sequester pro-apoptotic BH3-only proteins such as Bim Puma. damage...
The slow Wallerian degeneration (WldS) protein protects injured axons from degeneration. This unusual chimeric fuses a 70–amino acid N-terminal sequence the Ube4b multiubiquitination factor with nicotinamide adenine dinucleotide–synthesizing enzyme mononucleotide adenylyl transferase 1. requirement for these components and mechanism of WldS-mediated neuroprotection remain highly controversial. domain is necessary protective phenotype in mice, but precisely which essential why are unclear....
Decoding the functional connectivity of nervous system is facilitated by transgenic methods that express a genetically encoded reporter or effector in specific neurons; however, most lines show broad spatiotemporal and cell-type expression. Increased specificity can be achieved using intersectional genetic which restrict expression to cells co-express multiple drivers, such as Gal4 Cre. To facilitate targeting zebrafish, we have generated more than 50 new Cre lines, co-registered brain...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system's actual output - activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices ('Myomatrix arrays')...
To determine the rate of pregnancy and outcome in teenagers areas different socioeconomic conditions, to assess implication for achievement government local targets reducing unwanted pregnancies teenagers.Records were obtained from hospital discharge files rates live still births abortions calculated each postcode sector. Postcodes grouped by categories deprivation district.Tayside, Scotland.Teenage girls admitted National Health Service hospitals delivery or abortion 1980-90.Conception aged...
The biological factors responsible for differential chemoresponsiveness in oligodendroglial tumours with or without the -1p/-19q genotype are unknown, but tumour vascularity may contribute. We aimed to determine whether dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) could distinguish molecular subtypes of tumour, and examined relationship between relative cerebral blood volume (rCBV) outcome following procarbazine, lomustine vincristine (PCV) chemotherapy.Pretherapy...
The dynamic aspects of sports often place heavy demands on visual processing. As such, an important goal for training should be to enhance abilities. Recent research has suggested that in a stroboscopic environment, where experiences alternate between visible and obscured, may provide means improving attentional current study explored whether could impact anticipatory timing—the ability predict moving stimulus will at specific point time. Anticipatory timing is critical skill both non-sports...
Abstract Purpose To investigate whether oligodendroglial tumors with or without 1p/19q loss differ in their diffusion‐weighted imaging characteristics. Oligodendroglial therapeutic responsiveness and prognosis, recent reports also suggest that these may magnetic resonance characteristics blood volume. Materials Methods Apparent diffusion coefficients (ADCs) were assessed three grade II oligodendrogliomas, nine five III oligoastrocytomas known status. Regions of interest (ROIs) placed on ADC...
Abstract Purpose: Since the recognition that oligodendrogliomas may be chemosensitive, their diagnosis and clinical management has become highly controversial. Histopathology remains challenging new tools such as molecular genetics or imaging require evaluation. Experimental Design: In a single-center, population-based prospective study, allelic imbalance in chromosomes 1p36, 19q13, 17p13, 10p12–15, 10q22–26 been investigated 19 oligodendroglioma WHO grade 2 (OII), 20 oligoastrocytoma...
<b>Background: </b> The −1p/−19q genotype has been associated with prolonged survival and chemosensitivity in oligodendroglial neoplasms, but the predictive prognostic significance of routine clinic is not established. <b>Methods: authors investigated allelic imbalance 1p36, 19q13, 17p13, 10p12-15, 10q22-26 <i>p53</i> mutation a cohort representative clinical practice at their center (50 primary, 26 recurrent cases) given PCV chemotherapy between 2000 2003 compared response outcome following...
<b>Background: </b> Oligodendroglial neoplasms with combined loss of chromosomes 1p and 19q may have a good prognosis respond to procarbazine-lomustine (CCNU)-vincristine (PCV) chemotherapy. <b>Objective: To determine whether single voxel magnetic resonance spectroscopy (SV-MRS) obtained through routine clinical practice distinguishes between histopathologic genetic subtypes oligodendroglial tumors. <b>Methods: Forty-eight patients tumors (19 oligodendrogliomas 29 oligoastrocytomas)...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system’s actual output – activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices (“Myomatrix arrays”)...
To determine whether the period spent on true inpatient waiting list is a valid indication of total time that patients have to wait for an operation; and assess feasibility monitoring "postreferral time" by using existing computerised information systems.Three randomly selected Scottish hospitals.Waiting admitted hospital operations during June August 1993 in six major specialties, separate attention being focused cataract hip knee replacements.The operation after initial general...
Abstract The G protein‐coupled pheromone receptor neurons (V1R and V2R) of the vomeronasal organ (VNO) are continually replaced throughout lifetime mouse. Moreover, active signalling V2Rs via transient potential 2(TRPC2) channel is necessary for regeneration receptors, as TRPC2 null mutant mouse showed a 75% reduction by age two months. Here we describe V2R mediated in neuronal line established from stem cells taken postnatal female mice. Cells were immunoreactive Gα o V2R, whereas V1R i...