A5047775261- Birth, Development, and Health
- Renal and related cancers
- Pregnancy and preeclampsia studies
- Tuberous Sclerosis Complex Research
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
Hebrew University of Jerusalem
2021-2024
Hadassah Medical Center
2020-2022
Pediatric Nephrology of Alabama
2020
Low nephron number at birth is associated with a high risk of CKD in adulthood because nephrogenesis completed
Chronic kidney disease is the main cause of mortality in patients with tuberous sclerosis complex (TSC) disease. The mechanisms underlying TSC cystic remain unclear, no available interventions to prevent cyst formation. Using targeted deletion TSC1 nephron progenitor cells, we showed that cysts TSC1-null embryonic kidneys originate from injured proximal tubular cells high mTOR 1 activity. Injection rapamycin pregnant mice inhibited pathway and cell proliferation offspring. Rapamycin also...
Maternal caloric restriction during pregnancy significantly impacts kidney development, influencing susceptibility to chronic disease in adulthood. This study explores DNA methylation changes nephron progenitor cells resulting from and their implications for health. Global hypomethylation is observed progenitors caloric-restricted embryos, with specific genomic regions displaying distinct patterns, including hypermethylation. Differentially methylated exhibit enhanced chromatin...
Journal of the American Society Nephrology 33(11S):p 428, November 2022. | DOI: 10.1681/ASN.20223311S1428a