A5015354237- Autism Spectrum Disorder Research
- Gut microbiota and health
- Child Nutrition and Feeding Issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Infant Nutrition and Health
- Gastrointestinal motility and disorders
- Neonatal and fetal brain pathology
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Neuroscience of respiration and sleep
- Family and Disability Support Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Asthma and respiratory diseases
- Nerve injury and regeneration
Utrecht University
2020-2025
Wageningen University & Research
2020
Abstract Autism spectrum disorder (ASD) is a highly complex neurodevelopmental characterized by deficits in sociability and repetitive behaviour, however there great heterogeneity within other comorbidities that accompany ASD. Recently, gut microbiome has been pointed out as plausible contributing factor for ASD development individuals diagnosed with often suffer from intestinal problems show differentiated microbial composition. Nevertheless, studies rarely agree on the specific bacterial...
Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing evidence suggests that the microbiota-gut-brain axis likely related immune imbalance may play role development this disorder. Gastrointestinal gut microbiota dysfunction have been linked to or severity autistic Therefore, treatments focus on specific diets improve gastrointestinal function aberrant behavior individuals with ASD. In study, we...
Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities. In this study, changes in homeostasis and immunity a cigarette smoke (CS)- lipopolysaccharide (LPS)-induced COPD model were investigated. Mice exposed to or air for 72 days, except days 42, 52, 62 on which the mice treated saline LPS via intratracheal instillation. Cigarette exposure increased airway inflammatory cell numbers, mucus production, different mediators, including C-reactive protein...
Autism Spectrum Disorder (ASD) affects approximately 1 child in 54, with a 35-fold increase since 1960. Selected studies suggest that part of the recent prevalence is likely attributable to an improved awareness and recognition, changes clinical practice or service availability. However, this not sufficient explain epidemiological phenomenon. Research points possible link between ASD intestinal microbiota because many children display gastro-intestinal problems. Current large-scale datasets...
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, molecular mechanisms condition remain unknown. As intestinal problems and gut microbiota dysbiosis associated with ASD development severity, recent studies have focused on elucidating microbiota-gut-brain axis' involvement. This study aims explore through which might influence ASD. Briefly, we depleted conventional male BALB/cAnNCrl (Balb/c) C57BL/6J (BL/6) mice prior human fecal transplantation...
Brain-related comorbidities are frequently observed in chronic obstructive pulmonary disease (COPD) and related to increased progression mortality. To date, it is unclear which mechanisms involved the development of brain-related problems COPD. In this study, a cigarette smoke lipopolysaccharide (LPS) exposure murine model was used induce COPD-like features assess impact on brain behavior. Mice were daily exposed for 72 days, except days 42, 52, 62, mice intratracheally bacterial trigger...
Abstract Several Lactobacillus plantarum strains are marketed as probiotics for their potential health benefits. Prebiotics, e.g., galacto-oligosaccharides (GOS), have the to selectively stimulate growth of L. probiotic based on phenotypic diversity in carbohydrate utilization, and thereby enhance promoting effects host a strain-specific manner. Previously, we shown that GOS variably promotes . In this study investigated variation by molecular analysis utilization HPAEC-PAD revealed two...
The bacterial metabolite 4-methylphenol (para-cresol or p-cresol) and its derivative p-cresyl sulfate (pCS) are elevated in the urine feces of children with autism spectrum disorder (ASD). It has been shown that p-cresol administration induces social behavior deficits repetitive mice. However, mechanisms p-cresol, specifically pCS can reach brain, ASD remain to be investigated. inhibit LPS-stimulated inflammatory response. A Disintegrin And Metalloprotease 10 (ADAM10) 17 (ADAM17) thought...
<b>Introduction:</b> Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities, which considerably influence prognosis and clinical outcomes. However, the involvement of gut, as well cross-talk between gut lung, in immuno-pathophysiology COPD has hardly been investigated. <b>Aim:</b> In this study, changes homeostasis immunity a cigarette smoke-induced murine model for have <b>Methods:</b> Mice were exposed to smoke or air 72 days. The pathophysiology...