A5015903333- Prostate Cancer Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Telomeres, Telomerase, and Senescence
- Pain Management and Placebo Effect
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Climate Change and Health Impacts
- Anesthesia and Pain Management
- Prostate Cancer Treatment and Research
- Peripheral Neuropathies and Disorders
- Blood Pressure and Hypertension Studies
- Botulinum Toxin and Related Neurological Disorders
- Migraine and Headache Studies
- Complementary and Alternative Medicine Studies
- Glioma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Urologic and reproductive health conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Urinary Bladder and Prostate Research
- Global Health Care Issues
- Pain Mechanisms and Treatments
- Healthcare Systems and Public Health
- Cardiovascular Health and Risk Factors
European University Cyprus
2021-2025
National and Kapodistrian University of Athens
1977-2025
Pasteur Hellenic Institute
2017-2025
Laiko General Hospital of Athens
2021-2025
404 General Military Hospital
2025
Sismanoglio General Hospital
2023-2024
Hippocration General Hospital
2024
West Middlesex University Hospital
2024
Military Hospital
2024
University Hospital of Larissa
2024
Recent studies have revealed extensive neocortical pathology in multiple sclerosis (MS). The hippocampus is a unique archaeocortical structure understudied MS. It plays central role episodic and anterograde memory-the most frequently impaired cognitive modalities This histopathological study aimed to investigate inflammatory demyelination neurodegenerative changes the MS archaeocortex. A detailed quantitative analysis was performed on hippocampal autopsy tissue from 45 progressive cases...
The neurodegenerative processes driving the build-up of disability in progressive multiple sclerosis (P-MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence CS P-MS and sought determine its pattern. used 53BP1, p16, lipofuscin as markers white matter lesions (WMLs), normal appearing (NAWM), cortical gray (NAGM), control (CWM), (CGM) on autopsy material from patient with healthy controls. Senescence-associated...
Abstract The resident macrophages of the central nervous system, microglia, are becoming increasingly implicated as active participants in neuropathology and ageing. Their diverse changeable morphology is tightly linked with functions they perform, enabling assessment their activity through image analysis. To better understand contributions microglia health, senescence, disease, it necessary to measure both speed reliability. A machine learning approach was developed facilitate automatic...
FTY720, an oral sphingosine 1-phosphate (S1P) receptor modulator, has shown efficacy in phase II trials patients with relapsing-remitting multiple sclerosis (MS). Although this molecule is thought to immunosuppress by inhibiting lymphocyte egress from the lymph nodes, full spectrum of FTY720's actions not yet been uncovered. In study, we investigated effects FTY720 treatment on disease severity and histopathology MOG-induced experimental autoimmune encephalomyelitis (EAE) dark agouti (DA)...
The TNF/TNFR system exerts multiple proinflammatory and immunosuppressive functions in the pathogenesis of chronic inflammation autoimmunity. In EAE, experimental model Multiple Sclerosis (MS), genetic ablation TNFR2, results exacerbated immune reactivity disease course. underlying mechanism driving this function TNFR2 remains unclear. We show here that EAE KO mice is associated with increased Th17-cell responses reduced numbers Foxp3(+) Treg cells both spinal cord peripheral lymphoid...
Abstract Hypertension remains a major public health challenge with inadequate control globally. The May Measurement Month (MMM) global survey initiated by the International Society of (ISH) was implemented in Greece 2022 aiming to raise hypertension awareness and control. Adult volunteers were recruited through opportunistic screening 11 urban areas. Information on medical history three sitting blood pressure (BP) measurements obtained using validated automated upper-arm devices data...