A5040830972- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiac tumors and thrombi
- Long-Term Effects of COVID-19
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Clinical practice guidelines implementation
- Palliative Care and End-of-Life Issues
- Multiple and Secondary Primary Cancers
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Respiratory and Cough-Related Research
- Global Maternal and Child Health
- Systemic Lupus Erythematosus Research
University of Florida
2020-2024
University of Florida Health
2022-2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Florida College
2020-2023
University of Virginia
2023
Southeast Health District
2023
Banner - University Medical Center Phoenix
2021
Abstract Background Limited evidence is available to describe the prevalence, causes, and consequences of zinc vitamin B 6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc important for immune function wound healing, needed metabolic neurological function. Patients IBD are at risk micronutrient deficiencies, particularly during flares. Presentations The cases 2 patients exacerbations were reviewed which both identified. Conclusions These highlight need...
Trastuzumab-deruxtecan (T-DXd) is a novel antibody drug conjugate that has improved treatment outcomes in patients with ERBB2-positive cancer, including locally advanced or metastatic gastric and gastro-oesophageal junction adenocarcinoma. One of the reported side effects this medication drug-induced pneumonitis. We present case report, diagnostic dilemma patient presenting clinical radiographical features pneumonitis but was found to have pneumocystis jirovecii pneumonia (PJP). Our first...
DiGeorge syndrome (DGS) is caused by a chromosomal microdeletion at 22q11.2 that results in impaired development of the pharyngeal pouch system. Patients with DGS may have developmental abnormalities craniofacial structures, parathyroid glands, thymus and cardiac outflow tract. Doctors been routinely testing for newborns conotruncal anomalies since late 1990s; before then, however, they relied on complex diagnostic criteria disease was often missed. Adults born defects 1990s undiagnosed DGS....
The American Association for the Study of Liver Disease recommends screening patients with cirrhosis hepatocellular carcinoma (HCC) using imaging or without alpha-fetoprotein every six months. Unfortunately, rates remain inadequate.To assess root causes failure in a subspecialty hepatology clinic.The authors identified seen clinic and determined whether they underwent appropriate screening, defined as two cross-sectional images between five seven months apart. characterized primary driver...
Purpose The purpose of this paper is to describe restrictions on freedoms expression and press that have arisen during the coronavirus pandemic show public health impact these restrictions. Design/methodology/approach General PubMed Google searches were used review human rights violations both historically current pandemic. Special attention was paid publications produced by groups dedicated monitoring abuses. Findings During pandemic, many governments guise controlling virus silence critics...
Primary pulmonary artery sarcomas (PPAS) are extremely rare tumors that often mislabeled as emboli (PE). PPAS usually involve the trunk and histologically classified leiomyosarcoma, spindle cells sarcoma, fibrous histiocytoma, or undifferentiated sarcoma. Our case involved a 78-year-old man with an confined to left was initially misdiagnosed PE. After month-long delay in treatment which patient prescribed warfarin, correct diagnosis made. Pulmonary endarterectomy lung pneumonectomy were...
β-blockers (BBs) have shown promise in improving overall survival (OS) patients with breast, ovarian, pancreatic and lung cancer. However, few studies evaluated the impact of BBs on unresectable hepatocellular carcinoma (HCC).The authors compared clinical data outcomes between HCC based whether they were prescribed BBs.There was significantly decreased disease progression BB group non-BB (22.8 vs 28.0%; p < 0.05). No difference seen OS or progression-free groups. Those specifically selective...
Pancreatic adenosquamous carcinoma (PASC) is a rare cancer that often presents with advanced disease and carries grim prognosis. PASC defined by the presence of at least 30% malignant squamous cells in ductal adenocarcinoma. The utility chemotherapy setting metastatic unknown.In this cross-sectional analysis, patients stage IV diagnosed between 2006 2016 were abstracted from National Cancer Data Base. Patients then categorized according to whether they received chemotherapy. Multivariable...
The risk of developing another primary malignancy after an initial liver cancer diagnosis is rare, and the management multiple cancers not typically discussed. Focal nodular hyperplasia (FNH) considered a benign tumor, but there have been cases reported that describe hepatocellular carcinoma (HCC) arising from or within FNH. Here, we report woman in her 70s who had longstanding history FNH, later found to be HCC upon resection, also developed invasive ductal carcinoma. She no family genetic...
Prolonged hospitalizations have contributed to the concentration of American healthcare spending in a small subset patients. Research related such events is scarce. The authors performed retrospective analysis at tertiary care center between 2012 and 2022. Extensively prolonged hospitalization (EPH) was defined as an uninterrupted hospital stay least 183 days. Patient data, including past medical history, complications, barriers discharge, long-term outcomes were collected. Among 393,474...
Pregnancy-associated cancer is defined as malignancy diagnosed during gestation or up to 1 year post partum. Treatment of pregnancy complicated by the risk harm fetus and limitations in safety data. Postpartum patients receiving chemotherapy, tyrosine-kinase inhibitors hormonal agents should avoid breast feeding drug excretion milk. Patients who will receive cytotoxic chemotherapy be advised potential impact on their future fertility offered fertility-preservation options. Breast most common...
Duodenal adenocarcinoma (DA) is a rare malignancy without validated tumor markers. In practice, carcinoembryonic antigen (CEA) and carbohydrate (CA 19-9) are often used in the management of DA, though their prognostic value unknown.A single-institution retrospective review included patients diagnosed with biopsy-confirmed duodenum between 2006 2021. Peri-ampullary tumors were excluded. Levels CA 19-9 CEA collected as continuous variables analyzed binary variables: normal vs. high, using...
Sickle cell disease (SCD) is a diverse group of blood disorders with significant global burden. Contemporary interest in the underlying inflammatory paradigm SCD has emphasized role neutrophil-lymphocyte ratio (NLR) as prognostic marker.We retrospectively reviewed 268 hospitalized patients SCDs different genotypes (HbSS, HbSβ0 thalassemia, HbSβ+ and HbSC), totaling 3329 hospital admissions over 10-year period. Patients were stratified into SS/Sβ0 Sβ+/SC groups for statistical analysis...
Heterotaxy syndrome is a rare congenital defect of left-right laterality major visceral organs, often categorised by the presence symmetric left or right atrial heart chambers with single effective ventricle. Known as isomerism, these conditions may present distinct pattern extracardiac anomalies. palliated Fontan procedure and suggested to be subject similar long-term sequelae congestive hepatopathy ischaemia, increasing risk for hepatocellular carcinoma. Few works document primary,...
e16306 Background: Duodenal adenocarcinoma (DA) is a rare malignancy with poor outcomes. Tumor markers are used to assess disease response and monitor for recurrence. Specifically, CA-19-9 CEA have been validated use in pancreatic cancer colorectal cancer, respectively. However, these tumor never patients DA. We aim the association of biomarkers clinical outcomes Methods: This retrospective cohort study. After obtaining IRB approval (IRB202102705), we accessed University Florida medical...
The World Health Organization (WHO) criteria for diagnosis of hematopoietic and lymphoid cancers serve as a useful t-ool distinguishing between malignant conditions based on phenotypic, morphologic, and/or cytogenetic presentations, but their utility is limited in patients whose diseases contain elements multiple diagnoses. We present case 59-year-old male with enlargement muscular soft tissues the left hip an intraconal tissue mass surrounding optic nerve, who was treated Burkitt-like...
Synchronous colorectal cancer is a rare subtype of carcinoma defined by the presence 2 or more primary tumors simultaneously within 6 months initial detection. The overall impact synchronous presentation on prognosis not yet clear. Surgical resection treatment. However, higher rates local recurrence and metastasis in demand greater exploration role adjuvant therapy. increased frequency microsatellite instability observed also affects therapy selection. Similarly, activating PIK3CA mutations...
Autoimmune hepatitis (AIH) is a known risk factor for the development of hepatocellular carcinoma (HCC). However, current clinical guidelines do not offer systematic approach to surveillance and follow-up patients with AIH help diagnosis treatment HCC in this patient population. In case series, we describe presentation management eight who were diagnosed secondary underlying at University Florida Health Shands Hospital. Throughout their course, all identified have either histological or...
Post-transplant lymphoproliferative disorder (PTLD) is a rare condition that occurs in patients who have undergone solid organ transplantation. Symptoms at presentation depend on the organs involved. PTLD most commonly first year after transplant (early onset) or around 5 years (late onset). Herein, we report of central nervous system an adult presented with seizures 17 renal After extensive infectious and transplant-related workup, brain biopsy confirmed diagnosis PTLD. The patient was...