A5060025483- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Microwave-Assisted Synthesis and Applications
- Diet and metabolism studies
- Natural product bioactivities and synthesis
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Multicomponent Synthesis of Heterocycles
- Sodium Intake and Health
- Gastrointestinal motility and disorders
- Sulfur-Based Synthesis Techniques
- Cancer, Lipids, and Metabolism
- Bacterial Infections and Vaccines
- Extracellular vesicles in disease
- Dementia and Cognitive Impairment Research
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Clostridium difficile and Clostridium perfringens research
- Synthesis and biological activity
- Healthcare Systems and Public Health
Guangdong Medical College
2018-2022
Northwest Normal University
2001-2002
Lanzhou City University
2002
Outer membrane vesicles (OMVs) are nanosized produced by the gut microbiota (GM). The GM is well-known to be involved in pathological process of Alzheimer's disease (AD). However, mechanism OMVs not clear. In present study, we demonstrated involvement development cognitive (learning and memory) dysfunction induced blood-brain barrier (BBB) disruption. More important, further study showed that tau phosphorylation activating glycogen synthase kinase 3β (GSK-3β) hippocampus. activated...
Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal transplantation (FMT), aimed at rebuilding GM, has been proposed as new therapeutic approach to MS treatment. To evaluate viability FMT for treatment its impact on pathology, we tested in mice with experimental autoimmune encephalomyelitis (EAE), mouse model MS. We provide that can rectify altered GM some extent effect EAE. also found led reduced activation microglia astrocytes...
Background: Excessive salt intake is considered as an important risk factor for cognitive impairment, which might be the consequence of imbalanced intestinal homeostasis. Objective: To investigate effects dietary on gut microbiota and performance underlying mechanisms. Methods: Adult female C57BL/6 mice were maintained either normal chow (control group, CON) or sodium-rich containing 8% NaCl (high-salt diet, HSD) 8 weeks. Spatial learning memory ability, short-chain fatty acids (SCFAs)...
Abstract Background Atherosclerosis is the primary cause of coronary artery disease (CAD), and stearoyl‐CoA desaturase (SCD) associated with atherosclerosis. However, associations between variants SCD CAD have not yet been decided. Methods This study analyzed rs41290540 single‐nucleotide polymorphism (SNP) in 3′‐untranslated region for an association a risk among Chinese Han population. patients controls were genotyped SNP by SNaPshot. The binding affinity miR‐498 to was determined...
Amyloid-β (Aβ) is important in the etiology of Alzheimer's disease (AD). Removal Aβ from brain a major strategy for prevention and treatment AD.To clarify whether Aβ42 can be cleared by intestinal excretion gut microbiota (GM) affect excretory clearance peripheral blood intestines.Male 8-month-old C57BL6 mice were maintained on either normal chow or received broad-spectrum antibiotics their drinking water one week. Sterile saline, fluorescein isothiocyanate (FITC), FITC-Aβ42 (fluorescein...
ABSTRACT A simple, rapid, and efficient method for the synthesis of phenylacetyl arylthioureas under microwave irradiation is reported. The effects power, times, solvent on reaction are investigated.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”