About
Contact & Profiles
A5028084392
Research Areas
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Nuclear Structure and Function
Universitätsklinikum Würzburg
2023
Nuclear envelope proteins play an important role in the pathogenesis of hereditary cardiomyopathies. Recently, a new form arrhythmic cardiomyopathy caused by homozygous mutation (p.L13R) inner nuclear membrane protein LEMD2 was discovered. The aim to unravel molecular mechanisms mutant cardiomyopathy.We generated Lemd2 p.L13R knock-in mouse model and corresponding cell via CRISPR/Cas9 technology investigated cardiac phenotype as well cellular subcellular rupture repair.Knock-in mice...
10.1161/circresaha.122.321929
article
EN
Circulation Research
2023-01-04
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