A5042268323- Animal health and immunology
- Ion channel regulation and function
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Monoclonal and Polyclonal Antibodies Research
- Amino Acid Enzymes and Metabolism
- Plant Stress Responses and Tolerance
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Bird parasitology and diseases
- Viral gastroenteritis research and epidemiology
- Cardiac electrophysiology and arrhythmias
- Health, Technology, Consumer Behavior
- Insect symbiosis and bacterial influences
- Advanced Biosensing Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Vector-borne infectious diseases
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
- Aquaculture disease management and microbiota
- Parasites and Host Interactions
- Signaling Pathways in Disease
- Animal Nutrition and Physiology
- Transgenic Plants and Applications
- Cellular Automata and Applications
University of Coimbra
2019-2021
Universidade do Porto
2010-2016
Instituto de Biologia Molecular e Celular
2012-2013
Institute of Biomedical Science
2012
Instituto de Biología Molecular y Celular de Rosario
2012
Unit of Virus Host Cell Interactions
2008-2009
Université Joseph Fourier
2008-2009
Université Grenoble Alpes
2008-2009
Centre National de la Recherche Scientifique
2008-2009
CEA Grenoble
2008
During intracellular membrane trafficking and remodeling, protein complexes known as the ESCRTs (endosomal sorting required for transport) interact with membranes are budding processes directed away from cytosol, including of intralumenal vesicles to form multivesicular bodies; some enveloped viruses; daughter cell scission in cytokinesis. We found that ESCRT-III proteins CHMP2A CHMP3 (charged body 2A 3) could assemble vitro into helical tubular structures expose their interaction sites on...
KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation (K+ and Na+) transport proteins that closely resemble K+ channels. These underlie a plethora cellular functions are crucial for environmental adaptation in plants, fungi, archaea, bacteria. The activation mechanism remains unknown. It has been shown ATP stimulates activity while ADP does not. Here, we present X-ray structural information on complex with bound ADP. A comparison KtrAB-ATP structure reveals conformational changes...
Rickettsiae are obligate intracellular Gram-negative bacteria transmitted by arthropod vectors. Despite their reduced genomes, the function(s) of majority rickettsial proteins remains to be uncovered. APRc is a highly conserved retropepsin-type protease, suggested act as modulator other surface with role in adhesion/invasion. However, APRc's bacterial pathogenesis and virulence unknown. This study demonstrates that targets host serum components, combining nonimmune immunoglobulin...