A5005274219- Pharmacovigilance and Adverse Drug Reactions
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Retinal Development and Disorders
- Asthma and respiratory diseases
- Glaucoma and retinal disorders
- Trauma and Emergency Care Studies
- Respiratory and Cough-Related Research
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Cardiac electrophysiology and arrhythmias
- Ocular Infections and Treatments
- Pharmaceutical studies and practices
- Abdominal Surgery and Complications
- Hemodynamic Monitoring and Therapy
- Enhanced Recovery After Surgery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Pharmaceutical Economics and Policy
- Hip and Femur Fractures
- Influenza Virus Research Studies
- Zebrafish Biomedical Research Applications
- Testicular diseases and treatments
University of Pittsburgh
2018-2024
University of Oxford
2023
Gateshead Health NHS Foundation Trust
2023
Medical College of Wisconsin
2007-2022
Children's Hospital of Wisconsin
2016-2022
Madigan Army Medical Center
2021
University of Leeds
2019-2020
St James's University Hospital
2019-2020
University of Florida
2016-2018
St. Michael's Hospital
2018
The glaucomas comprise a genetically complex group of retinal neuropathies that typically occur late in life and are characterized by progressive pathology the optic nerve head degeneration ganglion cells. In addition to age family history, other significant risk factors for glaucoma include elevated intraocular pressure (IOP) myopia. complexity has made it difficult model animals, but also challenging identify responsible genes. We have used zebrafish complex, recessive mutant shows...
Lerner, E. Brooke PhD; Drendel, Amy L. DO, MS; Falcone, Richard A. Jr MD, MPH; Weitze, Keith C.; Badawy, Mohamed K. MD; Cooper, Arthur Cushman, Jeremy T. MS, EMT-P; Drayna, Patrick C. Gourlay, David M. Gray, Matthew P. Shah, Manish I. N. MPH Author Information
Between 2012 and 2017, the U.S. Food Drug Administration (FDA) approved 10 antidiabetic indicated therapies. Due to limited literature on voluntarily reported safety outcomes for recently drugs, this study investigated adverse drug reactions (ADRs) in FDA Adverse Event Reporting System (FAERS).A disproportionality analysis of spontaneously ADRs was conducted. FAERS reports from January 1, March 31, 2022 were compiled, allowing a 5-year buffer following approval 2017. odds ratios calculated...
Importance β-lactam (BL) allergies are the most common drug allergy worldwide, but reported in error. BL also well-established risk factors for adverse events and antibiotic-resistant infections during inpatient health care encounters, understanding of long-term outcomes patients with remains limited. Objective To evaluate clinical allergies. Design, Setting, Participants This longitudinal retrospective cohort study was conducted at a single regional system western Pennsylvania. Electronic...
Drug-induced QTc-prolongation is a well-known adverse drug reaction (ADR), however there limited knowledge of other drug-induced arrhythmias.The objective this study to determine the drugs reported be associated with arrhythmias than using FAERS database, possibly identifying potential causes that have not been previously.FAERS reports from 2004 quarter 1 through 2019 were combined create dataset approximately 11.6 million reports. Search terms for interest selected Standardized MedDRA...
The goal was to establish an accurate method for measuring intraocular pressure (IOP) in living adult zebrafish and determine the average IOPs of genetically different strains mutants. overall purpose develop system studies IOP glaucoma. Elevated anterior segment dysgenesis are two known risk factors Because albino mammals have increased prone anomalies, study focused on a reduced melanin mutant, brass.Servo-null electrophysiology used measure anesthetized zebrafish. A pulled-glass...
purpose. The structures of the ocular anterior segment responsible for aqueous humor secretion and absorption have been well characterized in mammals. However, underlying molecular cellular mechanisms that regulate flow remained elusive. Experimental analysis Danio rerio, zebrafish, is providing mechanistic insights into many processes relevant to normal human physiology disease. To facilitate studies on dynamics using this species, authors anatomy outflow adult zebrafish eyes. methods....
OBJECTIVES: Constipation is a common diagnosis in the pediatric emergency department (ED). Children diagnosed with constipation may undergo an abdominal radiograph (AXR) as part of their diagnostic workup despite studies that suggest AXR patient suspected being constipated unnecessary and potentially misleading. We aimed to decrease percentage low-acuity patients aged between 6 months 18 years who our ED from 60% 20% over 12 months. METHODS: conducted interventional improvement project at...
Rapid repetitive administration of short-acting β-agonists (SABA) is the most effective means reducing acute airflow obstruction in asthma. Little evidence exists that assesses process measures (ie, timeliness) and outcomes for We used quality improvement (QI) methods to improve emergency department care accordance with national guidelines including timely SABA use asthma severity scores.The Model Improvement was interventions were targeted at 4 key drivers: knowledge, engagement, decision...
Annual influenza vaccination is recommended for all US children 6 months and older to prevent morbidity mortality. Despite these recommendations, only ~50% of are vaccinated annually. Influenza vaccine administration in the pediatric emergency department (ED) an innovative solution improve rates. However, during 2017-2018 season, 75 vaccinations were given this tertiary care ED. We aimed increase number vaccines administered ED patients from 1,000 between August 2018 March 2019.s.Process...
Background: Ondansetron is a preferred anti-emetic in critical care to treat nausea and vomiting, has historically been considered largely safe option. A recent pharmacoepidemiology study reported that ondansetron may be associated with an increased risk for acute kidney injury (AKI). Methods: We interrogated the High-Density Intensive Care (HiDenIC-15) database containing intensive data 13 hospitals across Western Pennsylvania between Oct 2008-Dec 2014. AKI was defined using Kidney Disease,...
Diagnostic delays in the pediatric emergency department (ED) can lead to unnecessary interventions and prolonged ED length of stay (LOS), especially patients with diabetes mellitus evaluated for diabetic ketoacidosis (DKA). At our institution, baseline DKA determination time (arrival diagnosis) was 86 minutes, 61% did not meet criteria. Subsequently, intravenous (IV) placement occurred 85% without DKA. We aimed use point-of-care (POC) testing reduce from 30 minutes IV placements 20% over 18...
Abstract Background Emergency medical services ( EMS ) providers must be able to identify the most appropriate destination facility when treating children with potentially severe illnesses. Currently, no validated tool exists assist in identifying who need transport a hospital higher‐level pediatric care. For such developed, criterion standard needs defined that identifies received Objective The objective was develop consensus‐based for complaint resources. Methods Eleven local and national...
Abstract To perform an in‐depth analysis of opioid‐related ADRs reported by consumers, manufacturers and healthcare professionals. Delving into the depth breadth adverse drug reactions (ADRs) provides opportunity to strategize better clinical management alleviate safety concerns. Retrospective pharmacovigilance disproportionality for in FDA Adverse Event Reporting System (FAERS) database was performed. Detailed patient (sex, age) report (year report; reporter: worker vs consumer)...
The aim of this retrospective study was to assess the relation between carpal malalignment correction and radiological union rates in surgery for scaphoid nonunions. A total 59 waist fracture nonunions treated with open reduction palmar tricortical autograft were divided according their pre- postoperative scapholunate (SL) radiolunate (RL) angles. We found that failed correct 32 (54.2%) patients despite meticulous surgical technique placement an appropriately sized wedge-shaped graft. In...
Background In March 2014, the American Heart Association updated their guidelines for management of oral anticoagulation ( OAC ) in atrial fibrillation, recommending all patients with CHA 2 DS ‐ VAS c ≥2. Previously, only CHADS ≥2 were recommended anticoagulation. This study compared effectiveness and safety outcomes among who would receive using 2014 but not 2011 guidelines. Methods Results Using claims data from a 5% sample 2013–2014 Medicare beneficiaries, we identified initially...
Introduction: Drug toxicity and polypharmacy are major risk factors for delirium, especially in older adult patients with underlying comorbidities. However, numerous case reports have described drugs a lower suspicion of being deliriogenic. The objective this study was to identify deliriogenic the Food Administration Adverse Events Reporting System (FAERS) broaden public knowledge understanding. Study Design: Retrospective pharmacovigilance evaluation. Methods: FAERS from 2004 through 2015...