Koushik Ganesh
A5066589556- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Stress, Anesthesia, and Immune Response
Institut Curie
2022-2024
Inserm
2022-2024
Université Paris Sciences et Lettres
2022-2024
Abstract It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We identified four main CAF populations, two which are associated exclusion: (i) MYH11+αSMA+ CAF, present early-stage tumors and form single cell layer lining cancer aggregates, (ii) FAP+αSMA+ appear more advanced organize patches within the...
Abstract The majority of patients with bladder cancer initially present non-muscle-invasive disease (NMIBC). While NMIBC may be cured transurethral resection +/- intravesical therapies, approximately 20% develop progression to muscle-invasive (MIBC) which requires life-altering treatments such as cystectomy and has a high risk lethal metastatic recurrence. Current stratification for relies on clinicopathologic features that overlook the potential role tumor microenvironment (TME) in...
<div>Abstract<p>It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We identified four main CAF populations, two which are associated exclusion: (i) MYH11<sup>+</sup>αSMA<sup>+</sup> CAF, present early-stage tumors and form single cell layer lining cancer aggregates,...
<div>Abstract<p>It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We identified four main CAF populations, two which are associated exclusion: (i) MYH11<sup>+</sup>αSMA<sup>+</sup> CAF, present early-stage tumors and form single cell layer lining cancer aggregates,...
Supplementary Figure from Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors
Supplementary Figure from Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors