A5000666911- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Effects in Electronics
- Nuclear Physics and Applications
- Effects of Radiation Exposure
- Ion-surface interactions and analysis
- Boron Compounds in Chemistry
- Atomic and Molecular Physics
- Electron and X-Ray Spectroscopy Techniques
- Quantum, superfluid, helium dynamics
- Radiation Effects and Dosimetry
- Advanced Chemical Physics Studies
- Spectroscopy and Laser Applications
- Cold Atom Physics and Bose-Einstein Condensates
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Radiation Shielding Materials Analysis
- Nuclear reactor physics and engineering
- Particle accelerators and beam dynamics
- Atmospheric Ozone and Climate
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- Radiation Dose and Imaging
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications
2016-2025
Istituto Nazionale di Fisica Nucleare
2017-2025
University of Trento
2017-2025
University of Verona
2021
University of Pisa
2021
Nagoya University
2020
University of Milan
2020
GSI Helmholtz Centre for Heavy Ion Research
2011-2019
University of Turin
2019
Ospedale San Donato
2019
Abstract Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of the concentration is well described for X-rays. It has also been demonstrated that radioresistance in anoxia reduced using high-LET radiation rather than conventional However, dependence enhancement ratio (OER) on quality intermediate concentrations, those normally found tumours, had never measured...
We propose a multiscale approach to understand the physics related ion-beam cancer therapy. It allows calculation of probability DNA damage as result irradiation tissues with energetic ions, up $430\phantom{\rule{0.3em}{0ex}}\mathrm{MeV}∕\mathrm{u}$. This covers different scales, starting from large scale, defined by ion stopping, followed smaller secondary electrons and radicals, ending shortest interactions secondaries DNA. present calculations probabilities single double strand breaks...
LET-painting was suggested as a method to overcome tumour hypoxia. In vitro experiments have demonstrated well-established relationship between the oxygen enhancement ratio (OER) and linear energy transfer (LET), where OER approaches unity for high-LET values. However, radiation also increases risk side effects in normal tissue. attempts restrict compartments that are found be hypoxic, while applying lower LET normoxic tissues. Methods. Carbon-12 oxygen-16 ion treatment plans with four...
A possible dose enhancement effect by proton or electron irradiation in the vicinity of nanoparticles consisting different high Z atomic materials has been investigated using track structure Monte Carlo code TRAX. In simulations, Fe, Ag, Gd, Pt and Au (r = 22 2 nm) were irradiated with monoenergetic beams at energies therapeutic interest (2, 80 300 MeV) 44 keV electrons. Due to large number electrons atoms numbers, many can be released Auger cascades addition primary ionization process. The...
Charged particle therapy (CPT) is currently based on the use of protons or carbon ions for treatment deep-seated and/or radioresistant tumors, which are known to return poor prognosis in photon treatments. A renovated interest has recently been observed possibility extending spectrum used CPT. The potential and limitations different species will be discussed this work, with special regard 1H, 4He, 12C, 16O, that is, those presently available most advanced clinical centers.Literature...
Purpose: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially pediatric tumors. In order to assess potential these beams radiotherapy, i.e., create realistic treatment plans, authors set up a dedicated 4 He model, providing base data their planning system TRiP98, and they have reported that this work together with its physical biological validations. Methods: A semiempirical model depth...
Background and purpose: Recent observations in animal models show that ultra-high dose rate ("FLASH") radiation treatment significantly reduces normal tissue toxicity maintaining an equivalent tumor control. The dependence of this "FLASH" effect on target oxygenation has led to the assumption oxygen "depletion" could be its major driving force. Materials Methods: In a bottom-up approach starting from chemical track evolution 1 MeV electrons oxygenated water simulated with TRAX-CHEM Monte...
FLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra-high dose rates (>40 Gy/s) have been shown to reduce toxicity the normal tissue without compromising tumor control, resulting widened therapeutic window. These high are more easily achievable clinic with charged particles, and clinical trials are, indeed, ongoing using electrons or protons. could be an attractive solution also for heavier ions such as carbon even enhance However, it not yet known whether...
We present a method for adapting biologically optimized treatment planning particle beams to spatially inhomogeneous tumor sensitivity due hypoxia, and detected e.g., by PET functional imaging. The TRiP98 code, established system particles, has been extended including explicitly the oxygen enhancement ratio (OER) in biological effect calculation, providing first set up of dedicated ion beam approach directed hypoxic tumors, TRiP-OER, here reported together with experimental tests. A simple...
Nowadays there is a rising interest towards exploiting new therapeutical beams beyond carbon ions and protons. In particular, [Formula: see text]O are being widely discussed due to their increased LET distribution. this contribution, we report on the first experimental verification of biologically optimized treatment plans, accounting for different biological effects, generated with TRiP98 planning system beams, performed at HIT GSI. This implies measurements 3D profiles absorbed dose as...
The radiosensitivity of biological systems is strongly affected by the system oxygenation. On nanoscopic scale and molecular level, this effect considered to be related indirect damage radiation. Even though particle track radiolysis has been object several studies, still little known about impact target oxygenation on radical yields. Here we present an extension chemical module Monte Carlo structure code TRAX, taking into account presence dissolved oxygen in material. level evolution yields...
In the present paper we numerically investigate, using Monte Carlo simulation, theoretical results predicted by Generalized Stochastic Microdosimetric Model (GSM2), as shown in published companion paper. Taking advantage of particle irradiation data ensemble (PIDE) dataset, calculated GSM2 biological parameters human salivary gland (HSG) and V79 cell lines. Further, exploiting TOPAS-microdosimetric extension, simulated microdosimetric spectra different radiation fields therapeutic interest...
Ammonia inversion lines are often used as probes of the physical conditions in dense interstellar medium. The excitation temperature between first two para-metastable (rotational) levels is an excellent probe gas kinetic temperature. However, calibration this ammonia thermometer depends on accuracy collisional rates with H2. Here, we present new for ortho- and para-NH3 colliding para-H2(J= 0), investigate effects these ammonia. Scattering calculations employ a new, high-accuracy, potential...
We report on a novel method for simultaneous biological optimization of treatment plans hypoxic tumors using multiple ion species. Our previously introduced kill painting approach, where the overall cell killing is optimized biologically heterogeneous targets, was expanded with capability handling different beams simultaneously. The current version (MIBO) research planning system TRiP98 has now been augmented to handle 3D (voxel-by-voxel) target oxygenation data. present case idealized...
The energy distributions of secondary electrons produced by energetic carbon ions (in the range used, e.g., in hadron therapy), incident on liquid water, are discussed. For low-energy ions, a parametrization singly differential ionization cross sections is introduced, based tuning position Bragg peak. resulting allows fast calculation spectra at different depths along ion's trajectory, especially near At same time, this provides penetration for broad initial-ion energies within...
The production, diffusion, and interaction of particle beam induced water-derived radicals is studied with the a pre-chemical chemical module Monte Carlo track structure code TRAX, based on step by approach. After description model implemented, evolution most important products water radiolysis for electron, proton, helium, carbon ion radiation at different energies. validity verified comparing calculated time LET dependent yield experimental data from literature other simulation approaches.