A5078830612- Cardiac Valve Diseases and Treatments
- Circular RNAs in diseases
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related gene regulation
- Coronary Artery Anomalies
- interferon and immune responses
- Long-Term Effects of COVID-19
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Monoclonal and Polyclonal Antibodies Research
- Nitric Oxide and Endothelin Effects
- Cardiac and Coronary Surgery Techniques
- Cardiac Fibrosis and Remodeling
- Renal and Vascular Pathologies
- Cancer, Hypoxia, and Metabolism
Xinqiao Hospital
2009-2023
Army Medical University
2009-2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Daping Hospital
2007
MicroRNAs (miRs) regulate a number of physiological and pathological processes, including myocardial chronic hypoxia. Previous studies revealed that the expression miR-146b is increased in vitro vivo following induction In present study, role miR‑146b hypoxic cardiomyocytes, mechanisms underlying its activity, were investigated. The was measured tissue samples from patients with congenital heart disease by reverse transcription‑quantitative polymerase chain reaction. rat H9c2 cardiomyocyte...
Calcific aortic valve stenosis (CAVS) is the most common heart disorder among humans. To date, no effective method has been identified to prevent this disease. Herein, we aimed identify novel diagnostic and mitochondria-related biomarkers of CAVS, based on two machine learning algorithms. We further explored their association with infiltrating immune cells studied potential function in CAVS. The GSE12644, GSE51472, GSE83453 expression profiles were downloaded from Gene Expression Omnibus...
Objective. This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) acute myocardial ischemia (AMI) and exploring regulatory mechanisms of selected biomarker in mitochondrial oxidative damage vascular inflammation AMI pathology. Methods. Utilizing Gene Expression Omnibus dataset GSE66360, we scanned differentially expressed genes (DEGs) 49 patients 50 healthy subjects. To discover possible biomarkers, LASSO regression support vector machine...
Research Article10 June 2016Open Access Source DataTransparent process CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability Zhao Jian Institute of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China Search for more papers this author Bing Liang State Key Laboratory Proteomics, Basic Sciences, National Center Biomedical Analysis, Beijing, Xin Pan Guang Xu Sai-Sai Guo Ting Li Tao Zhou Ying-Bin Xiao Corresponding Author...
Introduction Albumin, which is a 65-kDa liver-synthesized protein, accounts for nearly 50% of total plasma protein and contributes to approximately 80% intravascular oncotic pressure. Albumin helps maintain microvascular integrity, functions as an antioxidant, transports hormones, fatty acid, bile salts, bilirubin, electrolytes (e.g., calcium, magnesium, copper, zinc, et al.), drugs.[1–3] Human serum albumin (HSA) sterile, liquid product derived from large pools human by fractionation...
Atrial fibrillation has caused severe burden for people worldwide. Differentiation of fibroblasts into myofibroblasts, and consequent progress in atrial structural remodeling have been considered the basis persistent fibrillation, yet little is known about molecular mechanisms underlying process. Here, we show that cyclin-dependent kinase 1 (CDK1) activated from patients with (AFPAF) platelet derived growth factor BB (PDGF-BB)-treated sinus rhythm (AFPSR). We also demonstrate inhibition CDK1...
Hypertrophic cardiomyopathy (HCM) and dilated (DCM) are classified as different diseases but have many similar pathogenic genes clinical symptoms. Previous research has focused on mutated genes. This study was conducted to identify key molecular mechanisms explore effective therapeutic targets.Myocardial tissue harvested from patients with HCM (n = 3) or DCM 4) during surgery. Hearts donated by healthy traffic accident victims were treated controls 4). Total proteins extracted for liquid...
Mechanical circulatory support (MCS) is an emerging therapy for acute heart failure (AHF) or cardiogenic shock (CS) patients unresponsive to medicinal treatment. In China, common treatments using short-term MCS include IABP and VA-ECMO, both found their limitations. A complementary strategy shall be proposed improve patients' prognosis, such as extracorporeal VAD (Extra VAD). Here, we reported results from a prospective, multicenter, single arm clinical trial involving forty conducted July...
The pandemic of the Coronavirus Disease 2019 (COVID-19) is ongoing exacerbated worldwide clinical consequence this disease was characterized with pneumonia and hypoxemia, even systemic injuries, especially in severe cases Patients underlying chronic cardiovascular diseases, or complicated new onsetting problems, were correlated a high mortality However, mechanisms myocardial vascular damage SARS-CoV-2 viral infection have not been clarified yet They might be direct invasion, cytokine storm...