A5037188043- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical synthesis and alkaloids
- Chemical synthesis and pharmacological studies
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Ureteral procedures and complications
- Migration, Identity, and Health
- Families in Therapy and Culture
- Electrochemical sensors and biosensors
- Ottoman and Turkish Studies
- Bioactive Compounds and Antitumor Agents
- Historical Turkish Studies
- Synthesis and Biological Evaluation
- Alzheimer's disease research and treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Chemical Sensor Technologies
- Pelvic floor disorders treatments
Erzincan Binali Yıldırım University
2019-2022
Gazi University
2017-2021
Abstract In this study, a series of N ‐substituted‐( p ‐tolyl)pyridazin‐3(2 H )‐one derivatives were synthesized and evaluated for their AChE inhibitory activity. The chemical structures novel compounds 5 ( – m ) confirmed by 1 H‐NMR, 13 C‐NMR, IR HRMS analysis. order to eliminate the symptomatic effects Alzheimer's disease, proposed acetylcholinesterase inhibition activity study in accordance with cholinergic hypothesis. results revealed that inhibited enzymes significantly. K i values...
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter regulation cognition in animals. Inhibition cholinesterases an effective method curb Alzheimer’s disease, progressive fatal neurological disorder. Objective: In this study, 30 new hydrazone derivatives were synthesized. Then we evaluated their anticholinesterase activity compounds. We...
Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated different experimental assays to assess their preliminary toxicity vivo anti-proliferative effects against HCT116 cell lines vitro. Artemia salina lethality test provided LC50 values >100 µg/mL for all compounds. Successive revealed that some compounds endowed with a promising effect cells, alone or stimulated by serotonin as pro-inflammatory factor order mimick an inflamed model of cancer...
Novel twenty-three 3(2H)-pyridazinone derivatives were designed and synthesized based on the chemical requirements related to anti-proliferative effects previously demonstrated within this scaffold. The introduction of a piperazinyl linker between pyridazinone nucleus additional (un)substituted phenyl group led some compounds endowed with limited cytotoxicity against human gingival fibroblasts (HGFs) good gastric adenocarcinoma cells (AGS) as evaluated by MTT LDH assays, using doxorubicin...
Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A -B inhibitory activities. T6 was found to be most potent MAO-B inhibitor with an IC50 value of 0.013 µM, followed by T3 (IC50 = 0.039 µM). Inhibitory potency more enhanced meta bromo substitution (T6) than para (T7). For substitution, potencies as follows: -Cl (T3) > -N(CH3)2 (T12) -OCH3 (T9) Br (T7) F (T5) -CH3 (T11) -H (T1). efficiently...
Demansların büyük çoğunluğundan sorumlu olan Alzheimer Hastalığı hızla yaşlanan nüfusla birlikte özellikle batı toplumlarında bir sağlık sorunu haline gelmiştir. Hastalığın doğası tam olarak anlaşılamasa da çeşitli hipotezlere dayalı ilaç geliştirme çalışmaları devam etmektedir. Mevcut ilaçlardan hiçbiri hastalığın ilerleyişini durduramamakta ya geri çevirememektedir. Bu nedenle de temelini hedef alan yeni ilaçlara gereksinim vardır. derlemede için mevcut kullanılan ve hedeflere yer...