A5072586009- Breast Implant and Reconstruction
- Sphingolipid Metabolism and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Caveolin-1 and cellular processes
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Advanced Neuroimaging Techniques and Applications
- Breast Cancer Treatment Studies
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Body Contouring and Surgery
- Digital Radiography and Breast Imaging
- Anorectal Disease Treatments and Outcomes
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and disorders
- Corneal Surgery and Treatments
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
Zhujiang Hospital
2011-2024
Southern Medical University
2010-2024
Wuhan Textile University
2015
Shanghai Jiao Tong University
2009-2013
State University of New York
2010-2011
SUNY Downstate Health Sciences University
2011
Wuhan University
2010
Fudan University
2010
Eli Lilly (United States)
2010
CAE (Canada)
2005
Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. It is known as an endogenous inhibitor lipoprotein lipase (LPL), and it modulates lipid deposition energy homeostasis. ANGPTL4 cleaved by unidentified protease(s), the biological importance this cleavage event not fully understood respect to its inhibitory effect on LPL activity. Here, we show that appears cell surface full-length form, where can be released heparin treatment in culture vivo. then...
Abstract Breast cancer is the most common type of carcinoma in women worldwide, but mechanisms underlying tumour development and progression remain unclear. Sphingomyelin synthase 2 (SGMS2) a crucial regulator involved ceramide (Cer) sphingomyelin (SM) homoeostasis that mostly studied for its role lipid metabolism. Our primary study indicated high SGMS2 expression associated with breast metastasis. Gain- loss-of-function assays vitro vivo revealed promotes cell proliferation by suppressing...
Aim. To investigate the correlation between Sirtuin 3 (SIRT3) expression and clinical outcome of patients with colon cancer. Methods . The tumor specimens from 127 cancer were obtained for SIRT3 immunohistochemical staining. Patients followed up. In in vitro study, gene was inhibited to observe effects on biological behavior cultured cells. Results level found be significantly associated lymph node metastasis (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
We used the sphingomyelin (SM) synthase 2 (Sms2) gene knockout (KO) approach to test our hypothesis that selectively decreasing plasma lipoprotein SM can play an important role in preventing atherosclerosis.The sphingolipid de novo synthesis pathway is considered a promising target for pharmacological intervention atherosclerosis. However, its potential hampered because substance's atherogenic mechanism not completely understood. prepared Sms2 and apolipoprotein E (Apoe) double-KO mice. They...
Abstract Objectives Multi-drug resistance (MDR) to chemotherapy is the main obstacle influencing anti-tumor effect in breast cancer, which might lead metastasis and recurrence of cancer. Until now, there are still no effective methods that can overcome MDR. In this study, we aimed investigate role sphingomyelin synthase 2 (SMS2) cancer resistance. Methods Quantitative RT-PCR analysis was performed assess changes mRNA expression. Western blot detect protein Inhibitory concentration value...
A comprehensive understanding of the pathology spinal cord injury (SCI) in non-human primates may facilitate greatly development new strategies to promote recovery humans with SCI. Relatively few studies, however, have been conducted systemically examine pathological changes monkey, a primate, after We report axonal, glial, and fibrotic responses monkey Macaca fascicularis thoracic (T) 8–9 lateral hemisection. examined these at three regions—i.e., lesion epicenter, peri-lesion area, white...
Spinal cord injury (SCI) in mammals not only damages the focal area, but also leads to wallerian degeneration (WD) of axons and myelin distal injury. In present study, we investigated cellular responses within areas WD a sensory pathway, fasciculus gracilis, after T8-9 lateral spinal hemisection adult monkey Macaca fascicularis. segments rostral caudal at two clinically-relevant time points, 1 week 4 weeks post-SCI, representing subacute chronic stages, respectively, were examined. We...
Abstract Artificial sphincters have been developed for patients with fecal incontinence, but finding a way to make such more “intelligent” remains problem. We assessed the function of novel intelligent artificial anal sphincter (IAAS) in vitro and vivo rabbits. After prosthesis was activated, rabbits were continent feces during 81.4% activation time. The detection unit provided 100% correct signals on stool 65.7% vivo. results indicated that IAAS could efficiently maintain continence detect...
Endoscopic axillary lymphadenectomy (EALND) was introduced to clinical work reduce side effects of conventional lymphadenectomy, while the lipolysis and liposuction EALND made process consume more time. The aim study determine whether immediate after tumescent solution injection axilla could shorten total time EALND. Fifty-nine patients were enrolled in study, 30 them received with traditional method (TLM), rest 29 (ILM). operation time, cosmetic result, drainage amount, hospitalization two...
The transmission of marking data nowadays require a separate PC as client at the receiving terminal in laser technology.This paper presents new and state feedback solution.It is industrial Ethernet that based on composition embedded network technology.The scheme integrates communication module which consists MAC's STM32F107 micro controller DM9161A PHY interface device.The control galvo scanner motion other basic modules make up unit this system.Furthermore,the generator executing agency...
Objective Analysis of the same pathological type,clinical stage (Ⅰ-Ⅱ) but expression breast cancer prognosis different genetic differences,screened gene combination meaningful,look for related with gene.Methods The Agilent 4 × 44 K human whole genome Oligo chip were used to screen 47 patients early tissue samples,combined their difference prognosis,divided into control group (poor prognosis) and experimental (good differential analysis.Results Microarray analysis revealed that sample than in...