A5100757184- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Orthopaedic implants and arthroplasty
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Biochemical and Structural Characterization
- Analytical Methods in Pharmaceuticals
- Magnetic Field Sensors Techniques
- Dielectric materials and actuators
- Cardiovascular Function and Risk Factors
- Bacterial biofilms and quorum sensing
- Electrical and Thermal Properties of Materials
- Advanced Sensor and Energy Harvesting Materials
- Advanced Drug Delivery Systems
- Conducting polymers and applications
- Drug Solubulity and Delivery Systems
- Photodynamic Therapy Research Studies
- Nanoparticles: synthesis and applications
- Cardiac Fibrosis and Remodeling
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Oral microbiology and periodontitis research
Peking University
2015-2025
Peking University Third Hospital
2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Chongqing Medical University
2011-2022
Chongqing Medical and Pharmaceutical College
2022
Chinese PLA General Hospital
2021
Children's Hospital of Chongqing Medical University
2017
China International Science and Technology Cooperation
2017
Changhai Hospital
2010-2014
Following myocardial infarction (MI), the accumulation of CD86-positive macrophages in ischemic injury zone leads to secondary damage. Precise pharmacological intervention targeting this process remains challenging. This study engineered a nanotherapeutic delivery system with macrophage-specific and ultrasound-responsive release capabilities. A folic acid (FA)–modified gene/drug system, assembled from DOTAP, DSPE-PEG2000-FA, cholesterol, perfluorohexane (PFH)—termed FA-PNBs—was developed...
Multidrug-resistant (MDR) pathogenic bacterial infections have become a major danger to public health. Synergetic therapy through multiple approaches is more powerful than the respective one alone, but has been rarely achieved in defeating MDR so far. Herein, indocyanine green-functionalized Mn3 O4 nanosheets are engineered as an efficient and safe antibacterial agent with photothermal, photodynamic, oxidase-like activities, which display ability treating infections. Therein, photothermal...
Abstract: A bioactive composite of nano calcium-deficient apatite (n-CDAP) with an atom molar ratio calcium to phosphate (Ca/P) 1.50 and poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCL–PEG–PCL) was synthesized, a scaffold fabricated. The scaffolds 40 wt% n-CDAP contained well interconnected macropores around 400 µm, exhibited porosity 75%. weight-loss the n-CDAP/PCL–PEG–PCL significantly greater than hydroxyapatite (n-HA, Ca/P = 1.67)/PCL–PEG–PCL during soaking into...
Abstract: Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength elastic modulus, as well hydrophilicity, m-MPC increased with increase m-MS content in composites. In addition, weight loss improved significantly during soaking phosphate-buffered saline for 10 weeks, indicating incorporation into...
Doped strontium enhanced the biological activity of CS/PAA composites for repairing large bone defects.
Nanoporous calcium silicate (n‐CS) with high surface area was synthesized using the mixed surfactants of EO 20 PO 70 (polyethylene oxide) (polypropylene , P123) and hexadecyltrimethyl ammonium bromide (CTAB) as templates, its composite poly(lactic acid‐co‐glycolic acid) (PLGA) were fabricated. The results showed that n‐CS/PLGA (n‐CPC) wt% n‐CS could induce a dense continuous layer apatite on after soaking in simulated body fluid (SBF) for 1 week, suggesting excellent vitro bioactivity. n‐CPC...
To develop a vancomycin-loaded superparamagnetic chitosan nanoparticles (Vm-SPMCNs) system for the treatment of chronic pyogenic osteoarthrosis to avoid critical side effects caused by systemic administration vancomycin, preparation process Vm-SPMCNs was optimized orthogonal array design method; optimum parameters were 1.2 g chitosan, 0.2 0.3 magnetite (Fe₃O₄), 12 mL glutaraldehyde and stirring at 400 rpm. The drug loading encapsulation efficiencies 10.30 ± 0.42% 79.02 1.81%, respectively....