A5050872734- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- RNA modifications and cancer
- DNA Repair Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Hypothalamic control of reproductive hormones
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Plant Virus Research Studies
- Bipolar Disorder and Treatment
- Child Development and Digital Technology
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Photosynthetic Processes and Mechanisms
- Nerve injury and regeneration
- 14-3-3 protein interactions
- Neurological disorders and treatments
- Biotin and Related Studies
- Stress Responses and Cortisol
New York University
2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2024
Lieber Institute for Brain Development
2017-2022
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
University of Minnesota
2020-2021
Although mismatch repair (MMR) is essential for correcting DNA replication errors, it can also recognize other lesions, such as oxidized bases. In G0 and G1, MMR kept in check through unknown mechanisms error-prone during these cell cycle phases. We show that mammalian cells, D-type cyclins are recruited to sites of oxidative damage a PCNA- p21-dependent manner. inhibit the proteasomal degradation p21, which competes with proteins binding PCNA, thereby inhibiting MMR. The ability limit CDK4-...
Brain-derived neurotrophic factor (Bdnf) transcription is controlled by several promoters, which drive expression of multiple transcripts encoding an identical protein. We previously reported that BDNF derived from promoters I and II highly expressed in hypothalamus critical for regulating aggression male mice. Here we report loss these causes reduced sexual receptivity impaired maternal care female mice, concomitant with decreased oxytocin (Oxt) during development. identify a novel link...
Synthetic transcription factors have great promise as tools to help elucidate relationships between gene expression and phenotype by allowing tunable alterations of without genomic the loci being studied. However, years-long timescales, high cost, technical skill associated with plant transformation limited their use. In this work, we developed a technology called VipariNama (ViN) in which vectors based on tobacco rattle virus are used rapidly deploy Cas9-based synthetic reprogram planta. We...
ABSTRACT The large majority of oxidative DNA lesions occurring in the G1 phase cell cycle are repaired by base excision repair (BER) rather than mismatch (MMR) to avoid long resections that can lead genomic instability and death. However, molecular mechanisms dictating pathway choice between MMR BER have remained unknown. Here, we show that, during G1, D-type cyclins recruited sites damage a PCNA- p21-dependent manner. shield p21 from its two ubiquitin ligases CRL1 SKP2 CRL4 CDT2...
Abstract Synthetic transcription factors have great promise as tools to explore biological processes. By allowing precise alterations in gene expression, they can help elucidate relationships between expression and plant morphology or metabolism. However, the years-long timescales, high cost, technical skill associated with transformation dramatically slowed their use. In this work, we developed a new platform technology called VipariNama (ViN) which RNA vectors are used rapidly deploy...
Abstract Brain-derived neurotrophic factor ( Bdnf ) transcription is controlled by several promoters, which drive expression of multiple transcripts encoding an identical protein. We previously reported that BDNF derived from promoters I and II highly expressed in hypothalamus critical for regulating aggression male mice. Here we report loss these causes reduced sexual receptivity impaired maternal care female mice, concomitant with decreased oxytocin Oxt) during development. identify a...
ABSTRACT The efficacy of electroconvulsive therapy (ECT) as a treatment for psychiatric disorders, including major depressive disorder (MDD) is hypothesized to depend on induction molecular and cellular events that trigger structural plasticity in neurons. Electroconvulsive seizures (ECS) animal models can help inform our understanding how impacts the brain. ECS induces neuronal dendrites many brain regions, piriform cortex, highly epileptogenic region has also been implicated depression....