A5019431916- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Pharmacogenetics and Drug Metabolism
- Bipolar Disorder and Treatment
- Epilepsy research and treatment
- Diet and metabolism studies
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Human Health and Disease
- Alcohol Consumption and Health Effects
- Cardiac electrophysiology and arrhythmias
- Treatment of Major Depression
- Migraine and Headache Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Sleep and related disorders
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Pharmaceutical studies and practices
- Spine and Intervertebral Disc Pathology
- Neurological diseases and metabolism
- Ion channel regulation and function
- Computational Drug Discovery Methods
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Tula State University
2024-2025
Samara State Medical University
2021-2024
St Nicholas Hospital
2024
Institute of the Human Brain
2023
Bashkir State Medical University
2023
Kazan Federal University
2020-2022
Russian Medical Academy of Continuous Professional Education
2022
Research Medical Center
2021-2022
Alcohol abuse has deleterious effects on human health by disrupting the functions of many organs and systems. Gut microbiota been implicated in pathogenesis alcohol-related liver diseases, with its composition manifesting expressed dysbiosis patients suffering from alcoholic dependence. Due to inherent plasticity, gut is an important target for prevention treatment these diseases. Identification impact alcohol associated psychiatric symptoms community structure confounded dysfunction. In...
Background . Eating behaviour disorder (EBD) induced by valproic acid (VPA) is one of the components pathogenesis a serious complication therapy with VPA and its salts such as VPA-induced metabolic syndrome (MetS). About 20% patients receiving have weight gain, which also consequence altered eating in patients. Substances neuropeptide Y (NPY), leptin, orexin ghrelin are involved regulation behaviour. NPY has received special attention recent years because it most potent brain orexigenic...
Relevance. Antipsychotics are widely used in psychiatry. Haloperidol remains one of the most commonly antipsychotics because its effectiveness. However, it has various adverse reactions, including an increased risk QT prolongation, a potentially fatal complication that can lead to Torsade de Pointes and sudden cardiac death. Objective. To systematize information for practicing psychiatrists clinical pharmacologists regarding personalized approach prevention interval prolongation patients...
Background: antipsychotics are widely used in psychiatry. Clozapine remains an indispensable antipsychotic due to its effectiveness. However, it has a wide range of undesirable effect, including increased risk QT prolongation, potentially fatal complication that can lead Torsade de Pointes (TdP) and sudden cardiac death. Objective: systematize information for practicing psychiatrists about personalized approach the prevention interval prolongation patients with mental disorders when taking...
The authors searched, analyzed and systematized the results of domestic foreign studies selective serotonin reuptake inhibitors-induced QT prolongation risk Torsade de pointes (full-text versions original articles, clinical cases, systemic reviews, meta-analyses, Cochrane reviews) in Russian English languages available bibliographic databases (eLIbRARY, PubMed, Scopus, Springer, ClinicalKeys, Oxford Press, Google Scholar, MedCredit, Drugbank, PharmGKb) to update knowledge practicing...
The authors searched, analyzed and systematized the results of domestic foreign studies SSRI- induced QT prolongation risk Torsades de Pointes (full-text versions original articles, clinical cases, systemic reviews, meta-analyses, Cochrane reviews) in Russian English languages available bibliographic databases (e-LIBRARY, PubMed, Scopus, Springer, ClinicalKeys, OxfordPress, Google Scholar, MedCredit, DrugBank, PharmGKB) to update knowledge practicing neurologists, cardiologists,...
Antipsychotic-induced parkinsonism (AIP) is a form of secondary that most often develops with blockade dopaminergic receptors type D2. However, AIP can oc-cur not only while taking first-generation APs, but also new ones have wider receptor pro-file. There connection between the DRD3 gene and regulation motor activity in associa-tion genetic studies AIP; Aim : to study role single-nucleotide variant rs167771 gene, encoding D3 type, risk Caucasian patients schizophrenia spectrum disorders...
Transcutaneous electrical nerve stimulation (TENS) is presently one of the main methods treatment for neuropathic pain in type II diabetes mellitus. The discussion about which TENS frequency more effective has been ongoing many years. Despite this, response different aspects to various modalities not sufficiently studied.To analyze changes characteristics depending on TENS.Seventy-five Russian diabetic patients with painful distal axonal neuropathy were enrolled study. Patients assigned...
Antipsychotics (APs) are psychotropic drugs that generally have a psycholeptic effect, capable of reducing psychotic symptoms and psychomotor agitation. This class is widely used in psychiatric practice, especially for the treatment psychosis schizophrenia other disorders. Most APs pass through biotransformation process, or metabolism, after they enter body before being eliminated. There three phases AP metabolism. Cytochrome P450 (CYP) monooxygenase (mixed-function oxidase) plays central...