A5064962855- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Veterinary medicine and infectious diseases
- X-ray Diffraction in Crystallography
- Conducting polymers and applications
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Electrochemical Analysis and Applications
- Cyclopropane Reaction Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Electrochemical sensors and biosensors
- Quinazolinone synthesis and applications
Universidad Católica del Norte
2020-2025
The synthesis of (E)-1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-3-phenyl-2-propen-1-one derivatives was carried out in two steps, using benzylic chloride as starting material. structural determination intermediates and final products performed by spectroscopic methods: infrared spectroscopy, nuclear magnetic resonance spectroscopy mass spectrometry (IR, NMR, MS). In vitro evaluation cytotoxic activity on adherent non-adherent cells showed that triazole chalcones exhibited significant...
A novel series of 6-iodo-2-methylquinazolin-4-(3H)-one derivatives, 3a-n, were synthesized and evaluated for their in vitro cytotoxic activity. Compounds 3a, 3b, 3d, 3e, 3h showed remarkable activity on specific human cancer cell lines when compared to the anti-cancer drug, paclitaxel. Compound 3a was found be particularly effective promyelocytic leukaemia HL60 non-Hodgkin lymphoma U937, with IC50 values 21 30 μM, respectively. 3d significant against cervical HeLa (IC50 = 10 μM). The...
This article describes the development of a nickel-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between N-substituted indoles donor–acceptor cyclopropanes to synthesize cyclopenta[b]indoles. Optimized reaction conditions provide desired nitrogen-containing cycloadducts in up 93% yield dr 8.6:1 with complete regioselectivity. The substrate scope showed high tolerance various substituted cyclopropanes, resulting synthesis six new cyclopenta[b]indoles isolation five...