A5019753963- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Surgical Simulation and Training
- Electrospun Nanofibers in Biomedical Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Anatomy and Medical Technology
- Enhanced Recovery After Surgery
- Augmented Reality Applications
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Cancer Genomics and Diagnostics
- Clinical Nutrition and Gastroenterology
- Cardiac Ischemia and Reperfusion
- Elasticity and Material Modeling
- 3D Printing in Biomedical Research
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2017-2025
Humboldt-Universität zu Berlin
2017-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2025
Weatherford College
2021
The paper evaluates the application of a mixed reality (MR) headmounted display (HMD) for visualization anatomical structures in complex visceral-surgical interventions. A workflow was developed and technical feasibility evaluated.Medical images are still not seamlessly integrated into surgical interventions and, thus, remain separated from procedure.Surgeons need to cognitively relate 2-dimensional sectional 3-dimensional (3D) during actual intervention. MR applications simulate 3D reduce...
Abstract Purpose Augmented reality (AR) and head-mounted displays (HMD) in medical practice are current research topics. A commonly proposed use case of AR-HMDs is to display data image-guided interventions. Although technical feasibility has been thoroughly shown, effects on interventions not yet well researched, hampering clinical applicability. Therefore, the goal this study better understand benefits limitations technology ultrasound-guided Methods We used an AR-HMD system (based...
A growing number of clinical risk scores have been proposed to predict allograft failure after liver transplantation. However, validation currently available in the Eurotransplant region is still lacking. We aimed analyze all clinically relevant donor and recipient on a large German transplantation data set performed retrospective cohort analysis transplantations at Charité—Universitätsmedizin Berlin from January 2007 until December 2021 with organs donation brain death. analyzed 9...
Recent developments in the field of augmented reality (AR) have enabled new use cases surgery. Initial set-up an appropriate infrastructure for maintaining AR surgical workflow requires investment hardware. We compared usability Microsoft HoloLens and Meta 2 head mounted displays (HMDs). Fifteen medicine students tested each device were questioned with a variant System Usability Scale (SUS). Two surgeons independently devices intraoperative setting. In our adapted SUS, ergonomics, ease use,...
Abstract Background While laparoscopic liver surgery has become a standard procedure, experience with robotic is still limited. The aim of this prospective study was to evaluate safety and feasibility compare outcomes conventional laparoscopy. Methods We here report the results single-center, prospective, post-marketing observational (DRKS00017229) investigating surgery. Baseline characteristics, surgical complexity (using IWATE score), postoperative were then compared resections performed...
Enhanced Recovery after Surgery (ERAS) is a multimodal approach to improve surgical outcome and has been implemented in many fields of surgery an international scale. The aim this study was evaluate the effect society recommendations liver impact on general surgery-related complications. 1049 patients who underwent from July 2018 October 2023 were included. ERAS program strictly followed official recommendations. As control group (Non-ERAS) 90 treated according clinic standard, while 959...
Abstract Background Colorectal cancer with liver metastasis affects both men and women. However, therapeutic strategies long-term outcomes could be influenced by patients’ sex, due to variations in tumour biology, lifestyle, dietary habits. By conducting a comprehensive comparative analysis, this study aims detail differences characteristics, postoperative complications, recurrence rates, survival between sexes. Methods Single-centre retrospective analysis 2010 2022 of all patients...
Zusammenfassung Die Zentralisierung der Lebertransplantation in Deutschland wird als vielversprechender Ansatz zur Verbesserung Versorgungsqualität durch höhere Fallzahlen und spezialisierte Strukturen betrachtet. Dennoch birgt sie erhebliche Herausforderungen für die chirurgische Weiterbildung. Eine reduzierte Verfügbarkeit von Weiterbildungsplätzen, eine mögliche Einschränkung Diversität klinischer Erfahrungen das Risiko Kapazitätsengpässen könnten langfristig Weiterbildung junger...
Due to the shortage of liver allografts and rising prevalence fatty disease in general population, steatotic grafts are considered for transplantation. This condition is an important risk factor outcome after We here analyze characteristics donor pool offered Charité – Universitätsmedizin Berlin from 2010 2016 with respect allograft nonacceptance steatosis hepatis. Of 2653 organs our center, 19.9% (n=527) were accepted transplantation, 58.8% (n=1561) allocated other centers, 21.3% (n = 565)...
To evaluate the outcome of marginal liver grafts based on Eurotransplant extended criteria donor (ECD) criteria.
Normothermic ex vivo liver machine perfusion might be a superior preservation strategy for grafts from extended criteria donors. However, standardized small animal models are not available basic research on of grafts. A laboratory‐scaled system was developed consisting custom‐made chamber, pressure‐controlled roller pump, and an oxygenator. Male Wistar rat livers were perfused via the portal vein 6 hours using oxygenated culture medium supplemented with erythrocytes. separate circuit...
Concepts to ameliorate the continued mismatch between demand for liver allografts and supply include acceptance of that meet extended donor criteria (ECD). ECD grafts are generally associated with an increased rate complications such as early allograft dysfunction (EAD). The costs transplantation health care system respect specific risk factors remain unclear subject change. We analyzed 317 transplant recipients from 2013 2018 outcome after hospital in a German center. In our study period,...
Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, transplantation (LT) required. The aim of our study was to compare short- long-term results after LR LT for the curative treatment hepatoblastoma. Materials Methods: Retrospective analysis all patients treated surgically from January 2000 until December 2019 performed. Demographic clinical data were collected before surgery. primary endpoints disease free...
Nicotinamide adenine dinucleotide (NAD + ), a coenzyme for more than 500 enzymes, plays central role in energy production, metabolism, cellular signaling, and DNA repair. Until recently, NAD was primarily considered to be an intracellular molecule (iNAD however, its extracellular species (eNAD ) has recently been discovered since associated with multitude of pathological conditions. Therefore, accurate quantification eNAD bodily fluids such as plasma is paramount answer important research...
The clinical role of lymphadenectomy (LAD) as part hepatic resection for malignancies the liver remains unclear. In this study, we aimed to report on use cases and postoperative outcomes simultaneous LAD (HM).
Considering the expected increase in elderly population and growing emphasis on aging-related biomedical research, demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a cost-effective method environmental enrichment, utilizing liver as representative organ assess potential metabolic changes response differing enrichment levels.
Ex vivo liver machine perfusion (MP) is a promising alternative for preservation of grafts from extended criteria donors. Small animal models can be used to evaluate different conditions. We here describe the development miniaturized ex MP system rat grafts, evaluating cell-free and erythrocyte-based solutions, subnormothermic normothermic temperatures, dialysis. A chamber was designed after suitable position identified. Normothermic (NEVLP) required supplementation erythrocytes reduce cell...
Abstract Background Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some no suitable replacements (i.e. autologous or prosthetic grafts) available. Advances have been made to develop tissue engineered vascular grafts (TEVG) using endothelial colony forming cells (ECFC) obtained by blood draw large animal trials. Clinical translation of this technique, however, still requires additional data for usability isolated ECFC high...
Pediatric liver transplantation (LT) is the treatment of choice for children with end-stage disease and in certain cases hepatic malignancies. Due to low case numbers, a technically demanding procedure, need highly specialized perioperative intensive care, immunological, as well infectious, challenges, highest level interdisciplinary cooperation required. The aim our study was analyze short- long-term outcomes pediatric LT center.We conducted retrospective single-center analysis all...