A5023339543- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Ocular Oncology and Treatments
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Polyomavirus and related diseases
- Hedgehog Signaling Pathway Studies
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Hematopoietic Stem Cell Transplantation
Memorial Sloan Kettering Cancer Center
2016-2025
New York Proton Center
2025
University of California, San Francisco
2024
Cornell University
2012-2024
National Cancer Institute
2005-2023
GTx (United States)
2022
International Drug Development
2022
Park University
2022
Kettering University
2013-2020
Radiation Oncology Associates
2012-2019
The abscopal effect is a phenomenon in which local radiotherapy associated with the regression of metastatic cancer at distance from irradiated site. may be mediated by activation immune system. Ipilimumab monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report case patient melanoma treated ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage responses to cancer-testis NY-ESO-1, changes...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cutaneous melanoma have been significantly revised over the past few years response to emerging data on immune checkpoint inhibitor therapies and BRAF-targeted therapy. This article summarizes rationale supporting extensive changes recommendations systemic therapy as adjuvant treatment of resected disease unresectable or distant metastatic disease.
Glioblastoma is the most common and aggressive primary brain tumour. Standard of care consists surgical resection followed by radiotherapy concomitant maintenance temozolomide (temozolomide/radiotherapy→temozolomide). Corticosteroids are commonly used perioperatively to control cerebral oedema frequently continued throughout subsequent treatment, notably radiotherapy, for amelioration side effects. The effects corticosteroids such as dexamethasone on cell growth in glioma models patient...
Over the past few years, NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways treatment of microscopic satellitosis (added in v2.2020), and following Principles sections: Molecular Testing v2.2019), Systemic Therapy Considerations Brain Metastases Management v3.2020). The v1.2021 update included additional modifications these sections notable revisions of: Pathology, Surgical Margins Wide Excision Primary Melanoma, Sentinel Lymph Node Biopsy, Completion/Therapeutic...
Immunotherapy is becoming the mainstay for treatment of a variety malignancies, but only subset patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play central role in antitumor immune responses. Noninvasive imaging CD8+ cells may provide new insights into mechanisms immunotherapy and potentially predict response. We are studying safety utility <sup>89</sup>Zr-IAB22M2C, radiolabeled minibody against cells, targeted with cancer. <b>Methods:</b> The initial...
<h3>Importance</h3> Recurrent and/or metastatic head and neck cancer is usually incurable. Implementation of precision oncology for these patients has been limited by incomplete understanding the molecular alterations underlying advanced disease. At same time, profiles many rare types are unknown. These significant gaps in knowledge need to be addressed rationally devise new therapies. <h3>Objective</h3> To illuminate distinct biology recurrent cancers review implementation with <h3>Design,...
Abstract Background. Subtypes of melanoma, such as mucosal, uveal, and acral, are believed to result in worse prognoses than nonacral cutaneous melanoma. After a diagnosis distant metastatic disease, however, the overall survival patients with cutaneous, unknown primary melanoma has not been directly compared. Materials Methods. We conducted single-center, retrospective analysis 3,454 diagnosed metastases from 2000 2013, identified prospectively maintained database. examined subtype, date...
Background The current study was conducted to evaluate the efficacy and safety of pembrolizumab‐mediated programmed cell death protein 1 inhibition plus radiotherapy (RT) in patients with metastatic triple‐negative breast cancer who were unselected for death‐ligand expression. Methods a single‐arm, Simon 2‐stage, phase 2 clinical trial that enrolled total 17 median age 52 years (range, 37‐73 years). An RT dose 3000 centigrays (cGy) delivered 5 daily fractions. Pembrolizumab administered...
External-beam radiation therapy (RT) is standard of care (SOC) for pain relief symptomatic bone metastases. We aimed to evaluate the efficacy asymptomatic metastases in preventing skeletal-related events (SRE).In a multicenter randomized controlled trial, adult patients with widely metastatic solid tumor malignancies were stratified by histology and planned SOC (systemic or observation) randomly assigned 1:1 ratio receive RT high-risk alone. The primary outcome trial was SRE. Secondary...
The NCCN Guidelines for Cutaneous Melanoma (termed Melanoma: Cutaneous) provide multidisciplinary recommendations diagnostic workup, staging, and treatment of patients. These Insights focus on the update to neoadjuvant systemic therapy options summarize new clinical data evaluated by panel recommended therapies in Version 2.2024 Melanoma.
After a large-scale nuclear accident or an attack with improvised device, rapid biodosimetry would be needed for triage. As possible means to address this need, we previously defined gene expression signature in human peripheral white blood cells irradiated ex vivo that predicts the level of radiation exposure high accuracy. We now demonstrate principle using from patients receiving total-body irradiation (TBI). Whole genome microarray analysis has identified genes responding significantly...