A5100770418- Invertebrate Immune Response Mechanisms
- Beetle Biology and Toxicology Studies
- Malaria Research and Control
- Insect Resistance and Genetics
- Coleoptera Taxonomy and Distribution
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Service-Oriented Architecture and Web Services
- Insects and Parasite Interactions
- Computational Drug Discovery Methods
- Bariatric Surgery and Outcomes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Virus Research Studies
- Advanced Software Engineering Methodologies
- Body Contouring and Surgery
- Neurological Disorders and Treatments
- Chromosomal and Genetic Variations
- Receptor Mechanisms and Signaling
- Air Quality and Health Impacts
- Energy and Environment Impacts
- RNA and protein synthesis mechanisms
- COVID-19 diagnosis using AI
- Genomics and Phylogenetic Studies
- Protease and Inhibitor Mechanisms
- Teratomas and Epidermoid Cysts
Hospital de La Ribera
2024
Instituto de Parasitología y Biomedicina "López - Neyra"
2018-2024
Consejo Superior de Investigaciones Científicas
2001-2023
Anaxomics (Spain)
2019-2021
Centre for Genomic Regulation
2018-2019
Estación Biológica de Doñana
2018-2019
Hospital Sierrallana
2014-2015
Hospital Jerez Puerta del Sur
2014
Centro de Estudios Científicos
2013
Qatar Foundation
2012
Human malaria is a devastating disease and major cause of poverty in resource-limited countries. To develop adapt within hosts Plasmodium falciparum undergoes drastic switches gene expression. identify regulatory regions the parasite genome, we performed genome-wide profiling chromatin accessibility two culture-adapted isogenic subclones at four developmental stages during intraerythrocytic cycle by using Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq). Tn5 transposase...
Infection by the human malaria parasite leads to important changes in mosquito phenotypic traits related vector competence. However, we still lack a clear understanding of underlying mechanisms and, particular, epigenetic basis for these changes. We have examined genome-wide distribution maps H3K27ac, H3K9ac, H3K9me3 and H3K4me3 ChIP-seq transcriptome RNA-seq, midguts from Anopheles gambiae mosquitoes blood-fed uninfected infected with natural isolates Plasmodium falciparum Burkina Faso....
Unveiling the mechanism of action a drug is key to understand benefits and adverse reactions medication in an organism. However, complex diseases such as heart there not unique but wide range different responses depending on patient. Exploring this collection mechanisms one clues for future personalized medicine. The Therapeutic Performance Mapping System (TPMS) Systems Biology approach that generates multiple models drug. Each molecular generated could be associated particular individuals,...
Recent advances in long read technologies not only enable large consortia to aim sequence all eukaryotes on Earth, but they also allow individual laboratories their species of interest with relatively low investment. Long embody the promise overcoming scaffolding problems associated repeats and complexity sequences, number contigs often far exceeds chromosomes may contain many insertion deletion errors around homopolymer tracts. To overcome these issues, we have implemented ILRA pipeline...
Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood-brain barrier (BBB). endothelium dysfunction is hallmark of BBB breakdown in most neurodegenerative/neuroinflammatory disorders. Therefore, identification new endogenous molecules involved endothelial cell disruption essential to better understand dynamics. Cortistatin neuroimmune mediator with anti-inflammatory neuroprotective properties that exerts beneficial...
ABSTRACT To survive and multiply in different host niches, malaria parasites require sets of proteins that are expressed during the life cycle a timely manner. Plasmodium malariae is human parasite present most malaria-endemic regions. However, this species remains enigmatic because it very challenging to culture, its low parasitaemia infections, frequent co-infection with other malarias. We investigate transcriptome P. transmission vector by analyzing RNA-seq data from midgut salivary gland...
Abstract Anopheles gambiae mosquitoes are primary human malaria vectors, but we know very little about their mechanisms of transcriptional regulation. We profiled chromatin accessibility by the assay for transposase-accessible sequencing (ATAC-seq) in laboratory-reared A. experimentally infected with parasite Plasmodium falciparum. By integrating ATAC-seq, RNA-seq and ChIP-seq data, showed a positive correlation between at promoters introns, gene expression active histone marks. comparing...
Abstract Flightless, phoretic insects of the tribe Meloini include several widespread species able to inhabit both mainland and oceanic continental islands. Relationships between non‐phoretic are unclear, precluding broad evolutionary biogeographic analyses within group. We provide a robust molecular phylogenetic framework for Meloini, with finer sampling in Western Palaearctic, by analysing two nuclear ( Wg , 18S) mtDNA cox1 16S) gene fragments 24 representing eight subgenera Meloe...
The prevalence of type 2 diabetes is increasing worldwide, accounting for 85-95% all diagnosed cases diabetes. Clinical trials provide evidence benefits low-carbohydrate ketogenic diets in terms clinical outcomes on patients. However, the molecular events responsible these improvements still remain unclear spite high amount knowledge primary mechanisms both and metabolic state ketosis. Molecular network analysis conditions, diseases treatments might new insights help build a better...
Eosinophilic oesophagitis (EoE) is characterized by the presence of eosinophils in oesophageal mucosa. Other inflammatory cells, mainly lymphocytes, dendritic and mast cells may also play an important role this disease. The aim study to compare pattern mucosa between EoE gastro-oesophageal reflux disease (GERD), using automatic image analysis digital slides, assess treatment response after elimination diet food challenge test.From 2010 2013, 35 biopsies from GERD patients were randomly...
This report presents a case of 65-year-old male suffering from penile cutaneous horn. lesion is usually seen in sun-exposed areas and its occurrence on the penis rare. One-third cases horns are associated with underlying malignancies. Standard treatment electrosurgical excision removal broad base.
Service-oriented architectures (SOA) foster software reuse and loose coupling by means of strongly restricting interactions to service contracts. Many companies have identified in SOA an opportunity not only improve their productivity but also promote extend B2B relationships. The ITECBAN project is a significant reference this process within the Spanish banking market. scope paper implementation paradigm enterprise-class environments based on JEE technology. SCA (Service Component...
Heat Stress Factor A9 (A9), a seed-specific transcription factor contributing to seed longevity, also enhances phytochrome-dependent seedling greening. The RNA-seq analyses of imbibed-seed transcripts here reported indicated potential additional effects on cryptochrome-mediated blue-light responses. These suggested that in contrast the which require coactivation by factors as A4a, alone might suffice for enhancement photomorphogenesis at stage. We found upon its overexpression, indeed...
Tailgut cysts or cystic hamartomas are rare developmental tumors of the presacral space. Their true incidence is not well known but we must think on it when have a patient with multicystic uncapsulated tumor at often asymptomatic, and in other cases present chronic perineal pain, constipation rectal tenesmus. They be treated to avoid complications such as infections (perianal fistula abscess) malignant degenerations (usually adenocarcinoma). One anal pain was diagnosed perianal abscess. He...
Software deployment deals with the transition of software assets from production to consumers' sites. Distributed systems are created by combination multiple components at runtime, possibly running on different devices over a network, making problem harder than in case centralized systems. This article presents model for description components, distributed systems, and their dependencies, mechanism that uses them automate units onto devices. These have been implemented validated study,...