A5032632652- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron ferroptosis, characterized lethal aggregation of lipid peroxidation. However, paucity ferroptosis-related biomarkers early identify IS until now. This study investigated potential gene pair and explored their roles immune infiltration.In total, we identified 6 differentially expressed genes (DEFRGs) the metadata cohort. Of these genes, 4 DEFRGs were incorporated into...
Oxidative stress (OS) and immune inflammation play complex intersections in the pathophysiology of ischemic stroke (IS). However, a competing endogenous RNA- (ceRNA-) based mechanism linked to IS has not been explored. We aimed identify potential OS-related signatures analyze infiltration characteristics IS. Three datasets (GSE22255, GSE110993, GSE140275) from GEO database were extracted. Differentially expressed long noncoding RNAs, microRNAs, messenger RNAs (DElncRNAs, DEmiRNAs, DEmRNAs)...