A5100362952- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diet and metabolism studies
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemophilia Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Hemostasis and retained surgical items
- Asthma and respiratory diseases
- Multiple Myeloma Research and Treatments
- Eating Disorders and Behaviors
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- Prenatal Screening and Diagnostics
- Iron Metabolism and Disorders
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Genetic Associations and Epidemiology
First Affiliated Hospital of Zhengzhou University
2022-2024
The First Hospital of Changsha
2024
Central South University
2024
Second Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Beihang University
2018
Novartis (China)
2016
Background A growing number of studies implies a strong association between gut microbiota and chronic obstructive pulmonary disease (COPD). However, the causal impact COPD remains unclear. As result, we used two-sample Mendelian randomization (MR) method to investigate connection in this study. Methods The largest available genome-wide study (GWAS) was obtained from MiBioGen consortium. Summary-level dataset for were FinnGen main analysis determining link inverse variance weighted (IVW)....
Geniposide (Gen) is a natural compound derived from Gardenia jasminoides that has anti-inflammatory, antioxidative stress, antiapoptotic, and antitumour properties. However, its mechanisms of action in idiopathic pulmonary fibrosis (IPF) have not been well studied. Recent studies found the progression IPF influenced by host metabolism. This study investigated antifibrotic effects metabolic modulation Gen. Gen significantly ameliorated pathological injury mouse model. reduced expression...
Non-Down's syndrome acute megakaryocytic leukemia (non-DS-AMKL) is a subtype of childhood myeloid (AML), whose prognosis, prognostic factors and treatment recommendations have not yet to be defined in children. We conducted retrospective study with 65 newly diagnosed non-DS-AMKL children from August 2003 June 2020 investigate the clinical impact outcome. Among all patients, 47 them were treated at our center who received three different regimens due time point admission (CAMS-another,...
Imatinib (Glivec) and nilotinib (Tasigna) have been covered by critical disease insurance in Jiangsu province of China since 2013, which changed local treatment patterns outcomes patients with chronic myeloid leukemia (CML). This study evaluated the long-term cost-effectiveness coverage imatinib as first-line for CML from a societal perspective. A decision-analytic model based on previously published real-world evidence was applied to simulate evaluate lifetime clinical economic associated...
Objective Observational studies have frequently shown a co-occurrence of psychiatric disorders and Obstructive sleep apnea (OSA), with major depressive disorder (MDD) being prevalent disorder. This study aims to investigate the genetic overlap between MDD OSA explore their underlying pathological mechanisms. Methods Leveraging extensive recent GWAS for MDD, we conducted correlation analyses utilizing Linkage disequilibrium score regression (LDSC), re-evaluated pleiotropic Single-nucleotide...
Abstract Background: Risk stratification for normal karyotype acute myeloid leukemia remains unsatisfactory, which is reflected by the high incidence of relapse. This study aimed to evaluate role gene mutations and clinical characterization in predicting relapse patients with leukemia. Methods: A prognostic system was constructed based on mutations, measurable residual disease, characteristics. panel explored using next-generation sequencing. The least absolute shrinkage selection operator,...