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Contact & Profiles
A5035254148
Research Areas
- Ubiquitin and proteasome pathways
- Biotin and Related Studies
- Click Chemistry and Applications
Pennsylvania State University
2020
Aberrantly processed or mutant proteins misfold and assemble into a variety of soluble oligomers insoluble aggregates, process that is associated with an increasing number diseases are not curable manageable. Herein, we present chemical toolbox, AggFluor, allows for live cell imaging differentiation complex aggregated conformations in cells. Based on the chromophore core green fluorescent proteins, AggFluor comprised series molecular rotor fluorophores span wide range viscosity sensitivity....
10.1021/jacs.0c07245
article
EN
Journal of the American Chemical Society
2020-09-11
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