A5034916296- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Child Development and Digital Technology
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- GABA and Rice Research
- Attention Deficit Hyperactivity Disorder
- Inflammatory Bowel Disease
- Child and Adolescent Psychosocial and Emotional Development
- Pancreatitis Pathology and Treatment
- Nerve injury and regeneration
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Prenatal Substance Exposure Effects
Aix-Marseille Université
2022-2024
Inserm
2022-2024
Institut de Neurobiologie de la Méditerranée
2022-2024
Associated Research (United States)
2022
Research International (United States)
2022
University of Florence
2019-2022
Prenatal exposure to the antiepileptic drug valproic acid (VPA) induces autism spectrum disorder (ASD) in humans and autistic-like behaviors rodents, which makes it a good model study neural underpinnings of ASD. Rats prenatally exposed VPA show profound deficits social domain. The altered behavior displayed by VPA-exposed rats may be due either deficit reward processing or more general inability properly understand respond signals. To address this issue, we performed behavioral,...
Abstract Cannabidiol (CBD), one of the main components cannabis, is generally considered safe. CBD crosses placenta and its use during pregnancy steadily increasing, impact gestational CBD’s effects on prenatal life neurodevelopment are poorly understood. Here, we combined behavioral approaches deep learning analysis to assess sex-dependent neonatal behavior exposed progeny. Gestating C57BL6/J dams were daily with vehicle or (3 mg/Kg, s.c.), from day 5 18. Body weight, pup ultrasound...
Abstract Background The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences behavior cognition. IC comprises two distinct subregions: the anterior (aIC), that processes social signals, posterior (pIC), specialized interoception perception of pain. Pyramidal projection neurons within integrate multimodal sensory inputs, influencing Despite previous research focusing on neuronal connectivity transcriptomics,...
Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism Fragile X Syndrome (FXS), disruptions in pup-dam USV communication hint at a possible connection between abnormal early developmental the later emergence of social deficits.
Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, passes through the placenta, affecting fetal development impacting offspring behavior. We investigated how prenatal exposure affects insular cortex (IC), a brain region involved in emotional processing linked psychiatric disorders. The IC is divided into two territories: anterior (aIC), socioemotional signals, posterior (pIC), specializing...
Abstract We investigated the molecular events triggered by NMDA and 3,5‐dihydroxyphenylglycine (DHPG) preconditioning, that lead to neuroprotection against excitotoxic insults (AMPA or oxygen glucose deprivation) in rat organotypic hippocampal slices, with particular attention on glutamate receptors cannabinoid system. firstly evaluated protein expression of AMPA receptor subunits after preconditioning using western blot analysis performed post‐synaptic densities. observed following NMDA,...
Abstract Background The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences behavior cognition. IC comprises two distinct subregions: the anterior (aIC), that processes social signals, posterior (pIC), specialized interoception perception of pain. Pyramidal projection neurons within integrate multimodal sensory inputs, influencing Despite previous research focusing on neuronal connectivity transcriptomics,...
Abstract Background The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences behavior cognition. IC comprises two distinct subregions: the anterior (aIC), that processes social signals, posterior (pIC), specialized interoception perception of pain. Pyramidal projection neurons within integrate multimodal sensory inputs, influencing Despite previous research focusing on neuronal connectivity transcriptomics,...
Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, passes through the placenta, affecting fetal development impacting offspring behavior. We investigated how prenatal exposure affects insular cortex (IC), a brain region involved in emotional processing linked psychiatric disorders. The IC is divided into two territories: anterior (aIC), socioemotional signals, posterior (pIC), specializing...
Many pregnant women use cannabidiol (CBD) as a natural remedy to alleviate symptoms such nausea, insomnia, anxiety, and chronic pain. As much 20% of pregnancies in the USA Canada may involve CBD-only products. CBD crosses placenta affect fetal development, potentially leading neuropsychiatric conditions later life. Given limited understanding effects during pregnancy, we adopted longitudinal approach investigate neurodevelopmental trajectory associated with prenatal exposure. Pregnant mice...
Abstract Pup-dam ultrasonic vocalizations (USVs) contribute to the formation of neural circuits and behaviors essential for standard cognitive socio-emotional development. In conditions like autism Fragile X Syndrome (FXS), disruptions in pup-dam USV communication hint at a possible connection between abnormal early developmental later emergence social deficits. Syntax, crucial element rodent "language," has rarely been investigated FXS mice, let alone specimens both sexes. Therefore, this...
Abstract Background : Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism Fragile X Syndrome (FXS), disruptions in pup-dam USV communication hint at a possible connection between abnormal early developmental the later emergence of social deficits. Methods Here, we gathered USVs from PND 10 FXS pups during short period separation their mothers, encompassing animals all genotypes both sexes (i.e., Fmr1-/y vs. Fmr1+/y males Fmr1+/+ , +/-...
Abstract Cannabidiol (CBD), one of the main components cannabis, is generally considered safe, despite lack studies on possible consequences its consumption during critical periods neurodevelopment, including prenatal life. Although CBD crosses placenta and use pregnancy steadily increasing, impact gestational exposure early life unknown. Here, we combined behavioral exploration deep learning to assess how in utero low doses alters pre-weaning behaviors mouse pups both sexes. The data reveal...
We previously demonstrated that prenatal exposure to valproic acid, an environmental model of autism spectrum disorder, leads a hyperexcitable phenotype associated downregulation inward-rectifying potassium currents in nucleus accumbens medium spiny neurons adolescent rats. Aberrant mTOR pathway function has been with autistic-like phenotypes multiple animal models, including gestational acid. The purpose this work was probe the involvement VPA-induced alterations striatal excitability....
Abstract Cannabidiol (CBD), one of the main components cannabis, is generally considered safe, despite lack studies on possible consequences its consumption during critical periods neurodevelopment, including prenatal life. Although CBD crosses placenta and use pregnancy steadily increasing, impact gestational exposure early life unknown. Here, we combined behavioral exploration deep learning to assess how in utero low doses alters pre-weaning behaviors mouse pups both sexes. The data reveal...