Yohyoh Wang
A5008868299- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Schizophrenia research and treatment
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Substance Abuse Treatment and Outcomes
- Personality Disorders and Psychopathology
New York Genome Center
2022-2025
Cornell University
2022-2025
Weill Cornell Medicine
2022
University of Illinois Chicago
2019
ABSTRACT Circulating cell-free DNA (ccfDNA) sequencing for low-burden cancer monitoring is limited by sparsity of circulating tumor (ctDNA), the abundance genomic material within a plasma sample, and pre-analytical error rates due to library preparation, errors. Sequencing costs have historically favored development deep targeted approaches overcoming in ctDNA detection, but these techniques are ccfDNA samples, which imposes ceiling on maximal depth coverage panels. Whole genome (WGS) an...
Abstract In many areas of oncology, we lack sensitive tumor-burden monitoring to guide critical decision making. While circulating tumor DNA (ctDNA) promises enable disease monitoring, this approach is limited by the sparsity ctDNA in plasma. To overcome challenge, error-corrected deep targeted sequencing has been proposed. Nonetheless, framework low number genomic equivalents (GEs, ~103/mL plasma), imposing a ceiling on effective depth. We have previously shown that genome-wide mutational...