A5003063630- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Cellular transport and secretion
- Antibiotic Resistance in Bacteria
- Legume Nitrogen Fixing Symbiosis
- Sleep and Wakefulness Research
- Physiological and biochemical adaptations
- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Escherichia coli research studies
- Neuroscience and Neuropharmacology Research
- Plant nutrient uptake and metabolism
- Olfactory and Sensory Function Studies
- Child Nutrition and Feeding Issues
- Cassava research and cyanide
- Infant Health and Development
- Neuroscience of respiration and sleep
- Bacterial Genetics and Biotechnology
Howard Hughes Medical Institute
2022-2024
University of California, San Francisco
2019-2024
Buck Institute for Research on Aging
2016-2018
Dominican University of California
2016
University of Leicester
1989
University of Dundee
1986
Food and water are rewarding in part because they satisfy our internal needs
The rewarding taste of food is critical for motivating animals to eat, but whether has a parallel function in promoting meal termination not well understood. Here, we show that hunger-promoting agouti-related peptide (AgRP) neurons are rapidly inhibited during each bout ingestion by signal linked the food. Blocking these transient dips activity via closed-loop optogenetic stimulation increases intake selectively delaying onset satiety. We upstream leptin-receptor-expressing dorsomedial...
Abstract Parkinson’s disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little about its potential role synaptic plasticity. Here demonstrate that postsynaptic knockdown fly homologue LRRK2 thwarts retrograde, homeostatic compensation at larval neuromuscular junction. Conversely, overexpression either or human transgene induces retrograde...
Retrograde signaling is essential for neuronal growth, function and survival; however, we know little about how endosomes might be directed from synaptic terminals onto retrograde axonal pathways. We have identified Khc-73, a plus-end microtubule motor protein, as regulator of sorting in Drosophila larval neurons. The number boutons the amount neurotransmitter release at Khc-73 mutant neuromuscular junction (NMJ) are normal, but find significant decrease presynaptic sites. This defect larvae...
The rewarding taste of food is critical for motivating animals to eat, but whether has a parallel function in promoting meal termination not well understood. Here we show that hunger-promoting AgRP neurons are rapidly inhibited during each bout ingestion by signal linked the food. Blocking these transient dips activity via closed-loop optogenetic stimulation increases intake selectively delaying onset satiety. We upstream leptin receptor-expressing dorsomedial hypothalamus (DMH