A5100624306- Business Process Modeling and Analysis
- Graph Theory and Algorithms
- Cryptography and Data Security
- Data Management and Algorithms
- Text and Document Classification Technologies
- Service-Oriented Architecture and Web Services
- Semantic Web and Ontologies
- Data Quality and Management
- Web Data Mining and Analysis
- Privacy-Preserving Technologies in Data
- Topic Modeling
- Access Control and Trust
- Prostate Cancer Treatment and Research
- Big Data Technologies and Applications
- Circular RNAs in diseases
- Big Data and Business Intelligence
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Energy Efficient Wireless Sensor Networks
- Underwater Vehicles and Communication Systems
- Epigenetics and DNA Methylation
- Advanced Text Analysis Techniques
- Cancer-related molecular mechanisms research
- Coastal and Marine Management
- Climate variability and models
Shanghai Ocean University
2014-2024
Chinese Academy of Sciences
2015-2024
Shanghai Institute of Materia Medica
2020-2024
Fourth Affiliated Hospital of Harbin Medical University
2018-2020
Harbin Medical University
2018-2020
Shanghai Institutes for Biological Sciences
2015-2019
Hebei University of Technology
2016-2019
Center for Excellence in Molecular Cell Science
2015-2019
University of Chinese Academy of Sciences
2018
Harbin Engineering University
2013
Clear cell renal carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer critically influences dissemination of cells.The effect exosomes isolated from (CSCs) CCRCC patients on the progress epithelial-mesenchymal transition (EMT) lung metastasis were examined.CSCs promoted proliferation accelerated EMT. Bioactive miR-19b-3p transmitted to CSC induced EMT via repressing expression PTEN. CSCs derived with produced strongest...
Underwater object detection plays a significant role in marine ecosystem research and species conservation. The improvement of related technologies holds practical significance. Although existing object-detection algorithms have achieved an excellent performance on land, they are not satisfactory underwater scenarios due to two limitations: the objects often small, densely distributed, prone occlusion characteristics, embedded devices limited storage computational capabilities. In this...
Facing the critical challenge in coordination control and uncertainty encountered leader–follower multi-agent systems, this study proposes a new adaptive backstepping sliding mode approach light of integration advantages principles. A systematic controller design procedure is proposed with step-by-step implement details. Correspondingly, stability analysis presented to lay foundation for analytical understanding generic theoretical aspects safe operation real systems. Two simulated examples...
Mammalian spermatogenesis is a classic adult stems cell-dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, identification SSCs elucidation their behaviors in undisturbed testis has long been big challenge. Here, we generated knock-in mouse model, Id4-2A-CreERT2-2A-tdTomato, which allowed us to mark Id4-expressing (Id4(+)) at different time points situ track across distinct developmental stages during steady-state regenerating...
Neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases, and interrupting microglial-mediated neuroinflammation has been suggested as a promising strategy to delay or prevent progression neurodegeneration. In this study, we investigated effects JE-133, optically active isochroman-2H-chromene conjugate containing 1,3-disubstituted isochroman unit, on lipopolysaccharide (LPS)-induced microglial underlying mechanisms both vitro vivo. First, JE-133 treatment...
It is aware that big data has gathered tremendous attentions from academic research institutes, governments, and enterprises in all aspects of information sciences. With the development diversity marine acquisition techniques, grow exponentially last decade, which forms . As an innovation, a double-edged sword. On one hand, there are many potential highly useful values hidden huge volume data, widely used marine-related fields, such as tsunami red-tide warning, prevention, forecasting,...
Marine heatwaves (MHWs) refer to a phenomenon where the sea surface temperature is significantly higher than historical average for that region over period, which typically result of combined effects climate change and local meteorological conditions, thereby potentially leading alterations in marine ecosystems an increased incidence extreme weather events. MHWs have significant impacts on environment, ecosystems, economic livelihoods. In recent years, global warming has intensified MHWs,...
Frizzled class receptor 1 (FZD1), a for Wnt signaling pathway. Overexpression of FZD1 has been detected in many cancer tissues and cells resulting tumor development drug resistance. However, its expression status prognostic merit renal still remains unclear. We screened the mRNA clear cell carcinoma (ccRCC) papillary (pRCC) from TCGA database Oncomine database. then sunitinib-resistant corresponding parental by qRT-PCR. level was significantly upregulated tissues, lines their cells. also...
Background/Aims: Emerging novel optical imaging techniques with cancer-specific molecular agents offer a powerful and promising platform for cancer detection resection. White-light cystoscopy random bladder biopsies remain the most appropriate but nonetheless suboptimal diagnostic technique cancer, which is associated high morbidity recurrence. However, white-light has intrinsic shortcomings. Although current technologies hold great potential improved accuracy, there are few specific...
Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with polypharmacological profiles is increasingly recognized as a promising therapeutic strategy against the multifactorial etiopathology Alzheimer's disease (AD). In this respect, series disubstituted aminopyrazole derivatives were designed and synthesized new class GSK-3β inhibitors. Most these possess inhibitory activities IC50 values in micromolar ranges, among which bisindole-substituted derivative 6h...
In addressing the challenges of non-standardization and limited annotation resources in Chinese marine domain texts, particularly with complex entities like long nested coral reef ecosystem-related existing Named Entity Recognition (NER) methods often fail to capture deep semantic features, leading inefficiencies inaccuracies. This study introduces a learning model that integrates Bidirectional Encoder Representations from Transformers (BERT), Gated Recurrent Units (BiGRU), Conditional...
Bladder cancer (BC) is the most common malignancy involving urinary system, and characterized by a high recurrence rate. It important to identify potential lncRNA signatures capable of predicting tumour risk assessing prognosis in BC patients. We extracted data from The Cancer Genome Atlas identified 381 differentially expressed lncRNAs, 855 mRNAs 70 miRNAs between non-recurrent recurrent tissues. Subsequently, competing endogenous RNA (ceRNA) network composed 29 13 4 was established. used...
Cephalopods are an essential component of marine ecosystems, which great significance for the development resources, ecological balance, and human food supply. At same time, preservation cephalopod resources promotion sustainable utilization also require attention. Many studies on classification cephalopods focus analysis their beaks. In this study, we propose a feature fusion-based method identification beaks, uses convolutional neural network (CNN) model as its basic architecture...
How to improve query efficiency in cryptograph database is an essential problem encryption technology. As one kind of methods for improving database, existing index technologies suffer from two main problems: low hit rate and lack information disclosure measures. In this paper, we propose a new method based on the probability distribution queries. We first define conception whole-wrong-hit expectation. Then complex bucket-partition technology, which used nonequiprobable query, strategy are...
Businesses and other organizations increasingly rely on business process management, a data-centric approach to workflow has emerged that are centered "artifacts". This introduced by IBM focuses data records, known as artifacts, correspond key relevant objects, flow through specified series of web services. Our researches carry this approach, create prototype for artifact-centric management systems, named A-Stein. In paper, the architecture A-Stein is firstly, then main portions in it...
Business data has been one of the current and future research frontiers, with such big characteristics as high-volume, high-velocity, high-privacy, so forth. Most corporations view their business a valuable asset make efforts on development optimal utilization these data. Unfortunately, management technology at present lagging behind requirements era. Based previous process knowledge, lifecycle is modeled to achieve consistent description between processes. On this basis, partition method...
Whether serine protease inhibitor Kazal type 1 (SPINK1) being associated with enzalutamide (Enz) resistance and metastasis of castration-resistant prostate cancer (CRPC) has not been clear. SPINK1 promoted Enz by upregulating Androgen receptor splicing variant 7 (ARv7), enhanced the invasion/migration Enz-resistant cells via ERK/p38/ MMP9 signaling. Furthermore, miR-5089-5p suppressed mRNA through direct binding to its 3'UTR, reversed pro-proliferative pro-metastatic effects. Mice bearing...
Existing marine sensor networks acquire data from sea areas that are geographically divided, and store the independently in their affiliated area centers. In case of events across multiple areas, current network structure needs to retrieve centers, thus severely affects real-time decision making. this study, order provide a fast retrieval service for network, we use all sensors as vertices, establish edge based on events, abstract graph. Then, construct multi-objective balanced partition...