A5052134475- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Invertebrate Immune Response Mechanisms
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Marine animal studies overview
- Microfluidic and Capillary Electrophoresis Applications
Instituto de Neurociencias
2018-2021
Consejo Superior de Investigaciones Científicas
2018-2021
Universitat de Miguel Hernández d'Elx
2020
Amherst College
2018
Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that signaling sensing fat sufficiency sexual commitment requires the lipid carrier apolipophorin in cells Sema1a neuroendocrine prothoracic gland (PG). Larvae lacking apolpp or fail to initiate despite accruing sufficient stores, they continue gaining weight until death. Mechanistically, peripheral body-fat levels via apolipophorin/Sema1a axis regulates endocytosis, endoplasmic reticulum...
Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that the prothoracic gland in Drosophila larvae monitors peripheral fat sexual commitment via semaphorin 1a (Sema1a). Larvae with knockdown of Sema1a do not mature, continue to grow excessively. The same phenotype occurs after reducing lipid carrier ApoB/lipophorin body. Super-resolution imaging revealed at weight, an endoplasmic reticulum trafficking signal is released permits protein...