A5064907376- Sphingolipid Metabolism and Signaling
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Cardiac Valve Diseases and Treatments
- TGF-β signaling in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pulmonary Hypertension Research and Treatments
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Caveolin-1 and cellular processes
- Blood disorders and treatments
- S100 Proteins and Annexins
- Antiplatelet Therapy and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Barrier Structure and Function Studies
- Renal Diseases and Glomerulopathies
- Medical Imaging and Pathology Studies
- Immune Response and Inflammation
- Periodontal Regeneration and Treatments
Hospital for Special Surgery
2017-2024
Cornell University
2017-2022
Weill Cornell Medicine
2017
Rockefeller University
2004-2016
New York University
2001
New York University Langone Orthopedic Hospital
2001
The vasculature of the central nervous system (CNS) forms a selective barrier termed blood-brain (BBB). Disruption BBB may contribute to various CNS diseases. Conversely, intact restricts efficient penetration CNS-targeted drugs. Here, we report BBB-regulatory role endothelial sphingosine 1-phosphate (S1P) receptor-1, G protein-coupled receptor known promote function in peripheral vessels. Endothelial-specific S1pr1 knockout mice (S1pr1iECKO ) showed breach for small-molecular-mass...
Cardiovascular diseases could be treated by chaperones that deliver the lipid mediator S1P promotes endothelial function.
Objective Immune complex ( IC ) deposition activates polymorphonuclear neutrophils PMN s), increases vascular permeability, and leads to organ damage in systemic lupus erythematosus rheumatoid arthritis. The bioactive lipid sphingosine 1‐phosphate (S1P), acting via S1P receptor 1 (S1P ), is a key regulator of endothelial cell EC barrier function. This study was undertaken investigate whether augmenting integrity signaling attenuates inflammatory injury mediated by s. Methods In vitro...
In rheumatoid arthritis, inflammatory mediators extravasate from blood into joints via gaps between endothelial cells (ECs), but the contribution of ECs is not known. Sphingosine 1-phosphate receptor 1 (S1PR1), widely expressed on ECs, maintains vascular barrier. Here, we assessed integrity and EC S1PR1 signaling to joint damage in mice exposed serum-induced arthritis (SIA). EC-specific deletion or pharmacological blockade promoted leak amplified SIA, whereas overexpression treatment with an...
<h3>Background</h3> Proliferative lupus nephritis (LN) is characterized by robust glomerular and tubulo- interstitial inflammation, sub-endothelial deposits of immunoglobulin, increased endothelial cell permeability. Sphingosine 1- Phosphate Receptor 1 (S1PR1) has multiple protective effects on cells (ECs): it maintains barrier function thereby protecting against vascular leakage, limits the number leukocytes adhering to transmigrating across ECs, protects ECs apoptosis in response...