A5100676922- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Wheat and Barley Genetics and Pathology
- Macrophage Migration Inhibitory Factor
- Apelin-related biomedical research
- Lung Cancer Treatments and Mutations
- Cardiovascular Disease and Adiposity
- Axon Guidance and Neuronal Signaling
- Colorectal Cancer Screening and Detection
- Drug-Induced Hepatotoxicity and Protection
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Effects of Exercise
- Antioxidant Activity and Oxidative Stress
- Pituitary Gland Disorders and Treatments
- Cardiomyopathy and Myosin Studies
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Xinjiang Agricultural University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2024
Sun Yat-sen University
2024
Weifang Medical University
2018-2024
Guizhou Provincial People's Hospital
2023
Shaoxing People's Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Nanfang Hospital
2019
Abstract M1 activation of macrophages promotes inflammation and immunity to intracellular pathogens, whereas M2 macrophage resolution inflammation, wound healing, tumor growth. These divergent phenotypes are characterized, in part, by the expression inducible NO synthase arginase I (Arg1) versus activated macrophages, respectively. In this study, we demonstrate that Ron receptor tyrosine kinase tips balance attenuating phenotype while promoting Arg1 through a Stat6-independent mechanism....
Plant height is a critical agronomic that affects both plant architecture and yield. To decipher the genetic mechanisms underlying winter wheat identify candidate genes associated with this trait, we conducted phenotypic analysis on 239 varieties (lines) collected from around world. This was complemented by genotyping using 55K SNP chip. A Wholegenome association (GWAS) of utilizing MLM (Q+K) model within TASSLE software. The results revealed significant variation in across different years,...
Reprograming of metabolic pathways is critical in governing the polarization macrophages into classical proinflammatory M1 or alternative anti-inflammatory M2 phenotypes diseases, such as diabetes. Porphyromonas gingivalis, a keystone pathogen periodontitis, causes an imbalance M1/M2 activation, resulting hyperinflammatory environment that promotes pathogenesis periodontitis. However, whether P. gingivalis infection modulates to alter macrophage remains unclear. Bone-marrow-derived (BMDMs)...
The RON receptor tyrosine kinase regulates the balance between classical (M1) and alternative (M2) macrophage activation. In primary macrophages, ligand for Ron, macrophage-stimulating protein (MSP), inhibits expression of inducible NO synthase, a marker classically activated whereas promoting arginase I, Ron(-/-) mice express increased levels IL-12, product after endotoxin administration, resulting in serum IFN-γ enhanced susceptibility to septic shock. this study, we demonstrate that MSP...
Abstract Obesity is a chronic inflammatory disease mediated in large part by the activation of macrophages. This inflammation underlies whole host diseases including atherosclerosis, hepatic steatosis, insulin resistance, type 2 diabetes, and cancer, among others. Macrophages are generally classified as either or alternatively activated. Some tissue-resident macrophages derived from yolk sac erythromyeloid progenitors fetal liver that seed tissues during embryogenesis have ability to...
To investigate the genetic mechanisms underlying reproductive traits (time to flowering and maturity) in wheat identify candidate genes associated, a phenotypic analysis was conducted on 239 accessions (lines) from around world. A genome-wide association study (GWAS) of heading maturity phases performed using MLM (Q+K) model TASSLE software, combined with Wheat 55K SNP array. The results revealed significant variation among across different years, coefficients ranging 0.96% 1.97%. data years...
Objective To explore circulating biomarkers for screening the invasiveness of non-functioning pituitary adenomas (NF-PAs). Methods The exosomal RNAs were extracted from serum patients with invasive NF-PA (INF-PA) or noninvasive (NNF-PA). Droplet digital PCR was adapted to detect mRNA expression candidate genes related tumor progression invasion, such as cyclin dependent kinase 6 (CDK6), ras homolog family member U (RHOU), and spire type actin nucleation factor 2 (SPIRE2). Student's t-test...
Obesity promotes a chronic inflammatory state that is largely mediated by tissue-resident macrophages as well monocyte-derived macrophages.Diet-induced obesity (DIO) valuable model in studying the role of macrophage heterogeneity; however, adequate isolations are difficult to acquire from inflamed tissues.In this protocol, we outline isolation steps and necessary troubleshooting guidelines derived our studies for obtaining suitable population mice following 18 weeks high-fat (HFD) or...
We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and genetic susceptibility to gestational diabetes mellitus (GDM).A total of 240 GDM pregnant women (GDM group) 330 healthy (control were included in study.Differences MIF genotype allele frequencies differences fasting blood glucose, insulin, homeostatic model assessment (HOMA)-insulin resistance, HOMA-b levels with different genotypes compared.MIF distributions...
Abstract Background Despite advances in treatments for gastric cancer (GC), new targets are needed to enhance treatment, especially when mesenchymal‐epithelial transition ( MET ) amplification is involved. Therefore, we investigated the genomic features of ‐amplified GC and efficacy anti‐ therapy. Methods Genomic were 2284 patients (cohort 1) 438 Cancer Genome Atlas (TCGA cohort). RNA data obtained from TCGA expression analysis. Clinical responses 71 2) investigated. Survival rates compared...
To investigate the protective effect of metformin against PM2.5-induced functional impairment placental trophoblasts and explore underlying mechanism.